Table 10.1
(continued)
Associated
compound or diet
type
Modulated genes
Function
Model
Cancer type
Reference
Caffeic acid
phenethyl ester
glutathione reductase;
p53;
P450;
CYP2B1
GST-j ;
GST-h;
Oxidative stress
Cell cycle regulation
Detoxification
In vivo (rats)
Liver
Beltrán-Ramírez
et al. (2010)
Omega-3 fatty acid EZH2;
Metastasis
In vitro (cell culture)
Breast
Dimri et al. (2010)
Dark chocolate
COX2;
RelA;
Inflammation
In vivo (rats)
Colon
DeIulio and Hong
(2010)
Grape-derived
polyphenols
VEGF;
MMP-2;
MMP-9;
COX-2;
p16:
p53:
p73:
Tumor vascularization
Tumor suppressor genes
In vivo (rats)
Colon
Walter et al. (2010)
Blueberry
Phytochemicals
PI3 K/AKT and NFjB;
Growth and metastatic In vivo (rats) and in vitro
(cell culture)
Breast
Adams et al. (2010)
Lycopene
IGFBP-3:
c-fos:
uPAR :
Bax:Bcl-2 ratio:
cyclin-D1;
p53;
Nrf-2;
Proliferation and
apoptosis
Carcinogenesis
Apoptosis
Cell cycle regulation
Ex vivo (human and cell
culture)
Prostate
Talvas et al. (2010)
(continued)
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