HisKA
ase
HATP
P
P
ADP
ATP
Periplasmic
sensor
REC
D
HTH
H
Transcription
Env Z
Omp R
a
P
P
P
P
ADP
ATP
REC
REC
D
D
HTH
H
HisKA
PAS
H
HPt
Transcription
Arc B
Arc A
b
P
P
P
P
ADP
ATP
HisKA
H
PAS
PAS
PAS
REC
REC
D
D
HTH
H
HPt
Transcription
Kin A
Spo 0F Spo 0B Spo 0A
c
ase
HATP
ase
HATP
Fig. 9.7 Functional schematics of two-component systems. (a) EnvZ/OmpR; (b) ArcB/Arca; (c) Kina/Spo0A. Drawing: M.-J. Bodiou
Table 9.4 Distribution, structure, and function of the main bacterial response regulators
Function of the effector domain
Examples of structure
Representatives
Binding to DNA
66 %
REC-wHTH
29.7 %
OmpR /PhoB
REC-HTH
16.5 %
NarL/FixJ
REC-AAA
+ -FIS
9.7 %
NtrC
REC-LytTR
2.9 %
LytR
Binding to RNA
1 %
REC-ANTAR
0.9 %
AmiR/NasR
Enzymatic activity
12 %
Methyltransfe ´rase
REC-CheB
2.3 %
CheB
Diguanylate cyclase
REC-GGDEF
3.4 %
di-cGMP phosphodiesterase
REC-EAL
1.8 %
di-cGMP phosphodiesterase
REC-HD-GYP
1.6 %
Proteine phosphatase
REC-PP2C
1 %
Histidine kinase
REC-HisKA-HATPase
1.9 %
Isolated receiver domain
14 %
Component of a phosphorelay
REC
Spo0F
Component of chemotaxis
REC
CheY
Others
7 %
The definition of domains is given in Table 9.2 (from Gao et al. 2007); http://www.ncbi.nlm.nih.gov/Complete_Genomes/SignalCensus.html
9 Adaptations of Prokaryotes to Their Biotopes and to Physicochemical Conditions. . .
305