Part A | 8.6
232 Part A Marine Flora and Fauna
Table 8.5 Examples of sponge-derived alkaloids with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.192]
Haliclona sp.
Manzamine A
Plasmodium berghei
[8.193]
Monanchora sp.
Crambescidin 826
HIV
[8.194]
Agelas sp.
Nagelamides A–H
Gram positive bacteria
[8.195]
Leucetta chagosensis
Naamine G
Cladosporium herbarum
[8.36]
Halichondria panicea
Circumdatin I
UV-A protectant
[8.196]
Agelas sp.
Nagelamide O
Gram positive bacteria
[8.181]
Ianthella flabelliformis Bastadin 25
ı-opoid receptor
[8.197]
Pandaros acanthifolium Pandaroside G
Trypanosoma brucei rhodesiense
[8.198]
Hyattella sp.
Psammaplysin G
Plasmodium falciparum
[8.199]
Aaptos aaptos
Aaptamine
NT2 (embryonal carcinoma) cells
[8.200]
Aaptos suberitoides
Suberitines B & D
P388 (lymphoblastic) cells
[8.201]
Haliclona sp.
Papuamine & Haliclonadiamine MCF-7 (breast), LNCap (prostate), Caco-2 (colon) and
HCT-15 (colon) cells
[8.191]
Agelas mauritiana
Ageloxime B
MRSA
Table 8.6 Examples of sponge-derived peptides with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.202]
Haliclona nigra
Haligramides A & B
cytotoxic
[8.178]
Haliclona sp.
Haliclonamides C, D & E
Mytilus edulis galloprovincialis
[8.183]
Aplysina aerophoba
lipopeptides
S. aureus, E. coli, Vibrio sp.,C. albicans
[8.203]
Neamphius huxleyi
Neamphamide A
HIV
[8.204]
Siliquariaspongia mirabilis Mirabamides A–D
HIV
[8.205]
Siliquariaspongia mirabilis Celebesides A–C & Theopapuamides B–D HIV
[8.206]
Eurypon laughlini
Rolloamides A & B
cytotoxic
[8.207]
Tedania sp.
Valinomycin
Leishmania major
[8.208]
Phakellia fusca
Phakellistatins 1518
P388 (lymphoblastic) cells
[8.209]
Holoxea sp.
L-Trp-L-Phe
cytotoxic
[8.210]
Discodermia calyx
Calyxamides A & B
P388 (lymphoblastic) cells
[8.211]
Cinachyrella apion
Lectin
HeLa cells
[8.212]
Pipestela candelabra
Pipestelides A–C
cytotoxic
Table 8.7 Examples of sponge-derived polyketides with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.213]
Theonella swinhoei
Theopederin
Antitumor
[8.214]
Cacospongia mycofijiensis Fijianolide
Antitumor
[8.215]
Siliquariaspongia mirabilis Mirabilin
Antitumor
[8.216]
Plakortis halichondrioides aromatic compounds
Anti-inflammatory
[8.217]
Plakortis cf., simplex
Manadoperoxides A–D Plasmodium falciparum
[8.218]
Plakortis sp.
Plakortide Q
Trypanosoma brucei brucei
[8.185]
Plakortis halichondrioides Plakortide O
Plasmodium falciparum
[8.33]
Halichondria panicea
Mayamycin
Anticancer, antibacterial
246], from sediment [8.247–249], and also from the
metagenome of marine sponges [8.142, 143, 250–254].
Screening of these marine sponge-derived metagenomic libraries has led to the identification of a number
of novel polyketide synthase (PKS) genes from the
sponges Discodermia dissoluta [8.142] and Pseudocer-
232 Part A Marine Flora and Fauna
Table 8.5 Examples of sponge-derived alkaloids with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.192]
Haliclona sp.
Manzamine A
Plasmodium berghei
[8.193]
Monanchora sp.
Crambescidin 826
HIV
[8.194]
Agelas sp.
Nagelamides A–H
Gram positive bacteria
[8.195]
Leucetta chagosensis
Naamine G
Cladosporium herbarum
[8.36]
Halichondria panicea
Circumdatin I
UV-A protectant
[8.196]
Agelas sp.
Nagelamide O
Gram positive bacteria
[8.181]
Ianthella flabelliformis Bastadin 25
ı-opoid receptor
[8.197]
Pandaros acanthifolium Pandaroside G
Trypanosoma brucei rhodesiense
[8.198]
Hyattella sp.
Psammaplysin G
Plasmodium falciparum
[8.199]
Aaptos aaptos
Aaptamine
NT2 (embryonal carcinoma) cells
[8.200]
Aaptos suberitoides
Suberitines B & D
P388 (lymphoblastic) cells
[8.201]
Haliclona sp.
Papuamine & Haliclonadiamine MCF-7 (breast), LNCap (prostate), Caco-2 (colon) and
HCT-15 (colon) cells
[8.191]
Agelas mauritiana
Ageloxime B
MRSA
Table 8.6 Examples of sponge-derived peptides with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.202]
Haliclona nigra
Haligramides A & B
cytotoxic
[8.178]
Haliclona sp.
Haliclonamides C, D & E
Mytilus edulis galloprovincialis
[8.183]
Aplysina aerophoba
lipopeptides
S. aureus, E. coli, Vibrio sp.,C. albicans
[8.203]
Neamphius huxleyi
Neamphamide A
HIV
[8.204]
Siliquariaspongia mirabilis Mirabamides A–D
HIV
[8.205]
Siliquariaspongia mirabilis Celebesides A–C & Theopapuamides B–D HIV
[8.206]
Eurypon laughlini
Rolloamides A & B
cytotoxic
[8.207]
Tedania sp.
Valinomycin
Leishmania major
[8.208]
Phakellia fusca
Phakellistatins 1518
P388 (lymphoblastic) cells
[8.209]
Holoxea sp.
L-Trp-L-Phe
cytotoxic
[8.210]
Discodermia calyx
Calyxamides A & B
P388 (lymphoblastic) cells
[8.211]
Cinachyrella apion
Lectin
HeLa cells
[8.212]
Pipestela candelabra
Pipestelides A–C
cytotoxic
Table 8.7 Examples of sponge-derived polyketides with bioactive properties
Reference Sponge species
Compound
Target of activity
[8.213]
Theonella swinhoei
Theopederin
Antitumor
[8.214]
Cacospongia mycofijiensis Fijianolide
Antitumor
[8.215]
Siliquariaspongia mirabilis Mirabilin
Antitumor
[8.216]
Plakortis halichondrioides aromatic compounds
Anti-inflammatory
[8.217]
Plakortis cf., simplex
Manadoperoxides A–D Plasmodium falciparum
[8.218]
Plakortis sp.
Plakortide Q
Trypanosoma brucei brucei
[8.185]
Plakortis halichondrioides Plakortide O
Plasmodium falciparum
[8.33]
Halichondria panicea
Mayamycin
Anticancer, antibacterial
246], from sediment [8.247–249], and also from the
metagenome of marine sponges [8.142, 143, 250–254].
Screening of these marine sponge-derived metagenomic libraries has led to the identification of a number
of novel polyketide synthase (PKS) genes from the
sponges Discodermia dissoluta [8.142] and Pseudocer-