Presenilin Proteins
63
tation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med 2:1146-1150
Levitan D, Doyle T, Brousseau D, Lee M, Thinakaran G, Slunt H, Sisodia S,
Greenwald I (1996) Assessment of normal and mutant human presenilin
function in Caenorhabditis elegans. Proc Natl Acad Sci USA
93:14940-14944
Mann DM, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD,
Poorkaj P, Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, HaItia M
(1996) Amyloid beta protein (Abeta) deposition in chromosome 14-linked
Alzheimer's disease: predominance of Abeta42(43).
Ann Neurol
40:149-156
Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos P, Brownstein MJ
(1998) Alpha synuclein in neurogenerative disorders: Murderer or accomlice? Nat Med 4:755-757
Naruse S, Thinakaran G, Luo J-J, Kusiak JW, Tomita T, Iwatsubo T, Qian X,
Ginty DD, Price DL, Borchelt DR, Wong, PC, Sisodia SS (1998) Effects of
PSI deficiency on membrane protein trafficking in neurons. Neuron
21:1213-1221
Price D, Sisodia S (1998) Mutant genes in familial Alzheimer's disease and
transgenic models. Annu Rev Neurosci 21:479-505
Schroeter EH, Kisslinger JA, Kopan R. (1998) Notch-I signalling requires ligand-induced proteolytic release of intracellular domain. Nature
393:382-386
Selkoe DJ (1996) Amyloid beta-protein and the genetcs of Alzheimer's disease. J BioI Chem 271: 18295-18298
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal
and CNS defects in Presenilin-l-deficient mice. Cell 89:629-639
Steiner H, Capell A, Pesold B, Citron M, Kloetzel P-M, Selkoe DJ, Romig H,
Mendla K, Haass C (1998) Expression of Alzheimer's diesease-associated
presenilin-l is controlled by proteolytic degradation and complex formation. J Bioi Chem 273:32322-32331
Struhl G, Adachi A (1998) Nuclear access and action of notch in vivo. Cell
93:649-660
Teplow D (1998) Structural and kinetic features of amyloid l3-protein fibrillogenesis. Amyloid 5: 121-142
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky
T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE,
Jenkins NA, Copeland NG, Price DL, Sisodia SS (1996) Endoproteolysis of
presenilin 1 and accumulation of processed derivates in vivo. Neuron
17:181-190
63
tation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med 2:1146-1150
Levitan D, Doyle T, Brousseau D, Lee M, Thinakaran G, Slunt H, Sisodia S,
Greenwald I (1996) Assessment of normal and mutant human presenilin
function in Caenorhabditis elegans. Proc Natl Acad Sci USA
93:14940-14944
Mann DM, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD,
Poorkaj P, Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, HaItia M
(1996) Amyloid beta protein (Abeta) deposition in chromosome 14-linked
Alzheimer's disease: predominance of Abeta42(43).
Ann Neurol
40:149-156
Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos P, Brownstein MJ
(1998) Alpha synuclein in neurogenerative disorders: Murderer or accomlice? Nat Med 4:755-757
Naruse S, Thinakaran G, Luo J-J, Kusiak JW, Tomita T, Iwatsubo T, Qian X,
Ginty DD, Price DL, Borchelt DR, Wong, PC, Sisodia SS (1998) Effects of
PSI deficiency on membrane protein trafficking in neurons. Neuron
21:1213-1221
Price D, Sisodia S (1998) Mutant genes in familial Alzheimer's disease and
transgenic models. Annu Rev Neurosci 21:479-505
Schroeter EH, Kisslinger JA, Kopan R. (1998) Notch-I signalling requires ligand-induced proteolytic release of intracellular domain. Nature
393:382-386
Selkoe DJ (1996) Amyloid beta-protein and the genetcs of Alzheimer's disease. J BioI Chem 271: 18295-18298
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal
and CNS defects in Presenilin-l-deficient mice. Cell 89:629-639
Steiner H, Capell A, Pesold B, Citron M, Kloetzel P-M, Selkoe DJ, Romig H,
Mendla K, Haass C (1998) Expression of Alzheimer's diesease-associated
presenilin-l is controlled by proteolytic degradation and complex formation. J Bioi Chem 273:32322-32331
Struhl G, Adachi A (1998) Nuclear access and action of notch in vivo. Cell
93:649-660
Teplow D (1998) Structural and kinetic features of amyloid l3-protein fibrillogenesis. Amyloid 5: 121-142
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky
T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE,
Jenkins NA, Copeland NG, Price DL, Sisodia SS (1996) Endoproteolysis of
presenilin 1 and accumulation of processed derivates in vivo. Neuron
17:181-190