64
c. Haass
Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR,
Sisodia SS (1998) Stable association of presenilin derivates and absence of
presenilin interactions with APP. Neurobiol Dis 4:438-453.
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido T, Maruyama K, Iwatsubo
T (1998) Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of trunctated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. J Bioi Chern 273 :21153-21160
Wolfe M, Xia W, Ostaszewski B, Diehl T, Kimberly W, Selkoe D (1999) Two
transmembrane aspartates in presenilin-I required for presenilin endoproteolysis and y-secretase activity. Nature 398:513-517.
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJS, Trumbauer
ME, Chen HY, Price DL, Van der Ploeg LHT, Sisodia SS (1997) Presenilin
I is required for Notch 1 and DIll expression in the paraxial mesoderm.
Nature 387:288-292
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva
EA, Xu M, Liang Y, Duthie M, St. George-Hyslop PH, Fraser PE (1998)
The presenilin I protein is a comonent of a high molecular weight intracellular co~plex that contains beta-catenin. J BioI Chern 273: 16740-16475
Zhang Z, Hartmann H, Do VM, Abramowski D, Strchler-Pierrat C, Staufenbiel
M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B,
Yankner BA (1998) Destabilization of beta-catenin by mutations in presenilin-I potentiates neuronal apoptosis. Nature 395:698-702
c. Haass
Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR,
Sisodia SS (1998) Stable association of presenilin derivates and absence of
presenilin interactions with APP. Neurobiol Dis 4:438-453.
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido T, Maruyama K, Iwatsubo
T (1998) Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of trunctated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. J Bioi Chern 273 :21153-21160
Wolfe M, Xia W, Ostaszewski B, Diehl T, Kimberly W, Selkoe D (1999) Two
transmembrane aspartates in presenilin-I required for presenilin endoproteolysis and y-secretase activity. Nature 398:513-517.
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJS, Trumbauer
ME, Chen HY, Price DL, Van der Ploeg LHT, Sisodia SS (1997) Presenilin
I is required for Notch 1 and DIll expression in the paraxial mesoderm.
Nature 387:288-292
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva
EA, Xu M, Liang Y, Duthie M, St. George-Hyslop PH, Fraser PE (1998)
The presenilin I protein is a comonent of a high molecular weight intracellular co~plex that contains beta-catenin. J BioI Chern 273: 16740-16475
Zhang Z, Hartmann H, Do VM, Abramowski D, Strchler-Pierrat C, Staufenbiel
M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B,
Yankner BA (1998) Destabilization of beta-catenin by mutations in presenilin-I potentiates neuronal apoptosis. Nature 395:698-702