62
c. Haass
References
Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C
(1997) Human presenilin-1, nut no familial Alzheimer's disease (FAD mutants), facilitate Caenorhabditis elegans Notch signalling independently of
proteolytic processing. Genes Funct 1:149-159
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther
K, Selkoe DJ, Haass C (1998) The proteolytic fragments of the Alzheimer's
disease-associated presinilin-l form heterodimers and occur as a 100-150kDa molecular mass complex. J BioI Chern 273:3205-3211
Citron M, Eckman CB, Diehl TS, Corcoran C, Ostazewski BL, Xia W, St.
George-Hyslop P, Younkin SG, Selkoe DJ (1998) Additive effect of PSI
and APP mutations on secretion of the 42-residue Amyioid ~-protein are
mediated by the PSI holoprotein. Neurobiol Dis 5:107-116
De Strooper B, Beullens M, CQntreras B, Levesque L, Craessaerts K, Cordell
B, Moechars D, Bollen M, Fraser P, St. George-Hyslop P, van Leuven F
(1997) Phosphorylation, subcellular localization, and membrane orientation
of the Alzheimer's disease-associated presenilins. J BioI Chern
272:3590-3598
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert
W, Von Figura K, van Leuven F (1998) Deficiency of presenilin-1 inhibits
the normal cleavage of amyloid precursor protein. Nature 391:387-390
DeStrooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm J,
Schroeter E, Schrijvers V, Wolfe M, Ray W, Goate A, Kopan R (1999) A
presenilin-1-dependent y-secretase-like protease mediates release of Notch
intracellular domain. Nature 398:518-522.
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M,
Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS (1996). Protein topology ofpresenilin 1. Neuron 17:1023-1030
Georgalis Y, Starikov EB, Lurz R, Scherzinger E, Saenger W, Lehrach H,
Wanker EE (1998) Huntingtin aggregation monitored by dynamic light
scattering. Proc Natl Acad Sci USA 95:6118-6121
Haass C, Selkoe DJ (1993) Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75:1039-1042
Haass C, Selkoe DJ (1998) Alzheimer's disease. A technical KO of amyloidbeta peptide. Nature 391:339-340
Jarret JT, Lansbury PT Jr (1993) Seeding "one-dimensional chrystallization"
of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?
Cell 73:1055-1058
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi
H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Koo EH, Goate
AM, Selkoe DJ, Arango JC (1996) The E280A presenilin 1 Alzheimer mu-
c. Haass
References
Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C
(1997) Human presenilin-1, nut no familial Alzheimer's disease (FAD mutants), facilitate Caenorhabditis elegans Notch signalling independently of
proteolytic processing. Genes Funct 1:149-159
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther
K, Selkoe DJ, Haass C (1998) The proteolytic fragments of the Alzheimer's
disease-associated presinilin-l form heterodimers and occur as a 100-150kDa molecular mass complex. J BioI Chern 273:3205-3211
Citron M, Eckman CB, Diehl TS, Corcoran C, Ostazewski BL, Xia W, St.
George-Hyslop P, Younkin SG, Selkoe DJ (1998) Additive effect of PSI
and APP mutations on secretion of the 42-residue Amyioid ~-protein are
mediated by the PSI holoprotein. Neurobiol Dis 5:107-116
De Strooper B, Beullens M, CQntreras B, Levesque L, Craessaerts K, Cordell
B, Moechars D, Bollen M, Fraser P, St. George-Hyslop P, van Leuven F
(1997) Phosphorylation, subcellular localization, and membrane orientation
of the Alzheimer's disease-associated presenilins. J BioI Chern
272:3590-3598
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert
W, Von Figura K, van Leuven F (1998) Deficiency of presenilin-1 inhibits
the normal cleavage of amyloid precursor protein. Nature 391:387-390
DeStrooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm J,
Schroeter E, Schrijvers V, Wolfe M, Ray W, Goate A, Kopan R (1999) A
presenilin-1-dependent y-secretase-like protease mediates release of Notch
intracellular domain. Nature 398:518-522.
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M,
Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS (1996). Protein topology ofpresenilin 1. Neuron 17:1023-1030
Georgalis Y, Starikov EB, Lurz R, Scherzinger E, Saenger W, Lehrach H,
Wanker EE (1998) Huntingtin aggregation monitored by dynamic light
scattering. Proc Natl Acad Sci USA 95:6118-6121
Haass C, Selkoe DJ (1993) Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75:1039-1042
Haass C, Selkoe DJ (1998) Alzheimer's disease. A technical KO of amyloidbeta peptide. Nature 391:339-340
Jarret JT, Lansbury PT Jr (1993) Seeding "one-dimensional chrystallization"
of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?
Cell 73:1055-1058
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi
H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Koo EH, Goate
AM, Selkoe DJ, Arango JC (1996) The E280A presenilin 1 Alzheimer mu-