Hedgehog Signaling in Animal Development and Human Disease 233
Porter JA, Young KE, Beachy PA (1996) Cholesterol modification of hedgehog
signaling proteins in animal development. Science 274:255-259
Preat T, Therond P, Lamour-Isnard C, Limbourg-Bouchon B, Tricoire H, Erk I,
Mariol MC, Busson D (1990) A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. Nature 347:87-89
Radhakrishna U, Wild A, Grzeschik KH, Antonarakis SE (1997) Mutation in
GLI3 in postaxial polydactyly type A. Nat Genet 17:269-271
Raffel C, Jenkins RB, Frederick L, Hebrink D, Alderete B, Fults DW, James
CD (1997) Sporadic medulloblastomas contain PTCH mutations. Cancer
Res 57:842-845
Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P,
Reifenberger G (1998) Missense mutations in SMOH in sporadic basal cell
carcinomas of the skin and primitive neuroectodermal tumors of the central
nervous system. Cancer Res 58: 1798-1803
Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP
(1997) Hedgehog elicits signal transduction by means of a large complex
containing the kinesin-related protein costal2. Cell 90:225-234
Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz i Altaba A,
Tanabe Y, Placzek M, Edlund T, Jessell TM (1994) Floor plate and motor
neuron induction by vhh-l, a vertebrate homolog of hedgehog expressed by
the notochord. Cell 76:761-775
Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM
(1995) Floor plate and motor neuron induction by different concentrations
of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.
Cell 81 :445-455
Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC,
Muenke M (1996) Mutations in the human Sonic Hedgehog gene cause
holoprosencephaly. Nat Genet 14:357-360
Roessler E, Belloni E, Gaudenz K, Vargas F, Scherer SW, Tsui LC, Muenke M
(1997) Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly. Hum Mol Genet 6:1847-1853
Ruppert JM, Kinzler KW, Wong AJ, Bigner SH, Kao FT, Law ML, Seuanez
HN, O'Brien SJ, Vogel stein B (1988) The GLI-Kruppel family of human
genes. Mol Cell Bioi 8:3104-3113
Ruppert JM, Vogelstein B, Arheden K, Kinzler KW (1990) GLI3 encodes a
190-kilodalton protein with multiple regions of GLI similarity. Mol Cell
Bioi 10:5408-5415
Sisson JC, Ho KS, Suyama K, Scott MP (1997) Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90:235-245
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott
MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper IE, de Sauvage F,
Porter JA, Young KE, Beachy PA (1996) Cholesterol modification of hedgehog
signaling proteins in animal development. Science 274:255-259
Preat T, Therond P, Lamour-Isnard C, Limbourg-Bouchon B, Tricoire H, Erk I,
Mariol MC, Busson D (1990) A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. Nature 347:87-89
Radhakrishna U, Wild A, Grzeschik KH, Antonarakis SE (1997) Mutation in
GLI3 in postaxial polydactyly type A. Nat Genet 17:269-271
Raffel C, Jenkins RB, Frederick L, Hebrink D, Alderete B, Fults DW, James
CD (1997) Sporadic medulloblastomas contain PTCH mutations. Cancer
Res 57:842-845
Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P,
Reifenberger G (1998) Missense mutations in SMOH in sporadic basal cell
carcinomas of the skin and primitive neuroectodermal tumors of the central
nervous system. Cancer Res 58: 1798-1803
Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP
(1997) Hedgehog elicits signal transduction by means of a large complex
containing the kinesin-related protein costal2. Cell 90:225-234
Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz i Altaba A,
Tanabe Y, Placzek M, Edlund T, Jessell TM (1994) Floor plate and motor
neuron induction by vhh-l, a vertebrate homolog of hedgehog expressed by
the notochord. Cell 76:761-775
Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM
(1995) Floor plate and motor neuron induction by different concentrations
of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.
Cell 81 :445-455
Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC,
Muenke M (1996) Mutations in the human Sonic Hedgehog gene cause
holoprosencephaly. Nat Genet 14:357-360
Roessler E, Belloni E, Gaudenz K, Vargas F, Scherer SW, Tsui LC, Muenke M
(1997) Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly. Hum Mol Genet 6:1847-1853
Ruppert JM, Kinzler KW, Wong AJ, Bigner SH, Kao FT, Law ML, Seuanez
HN, O'Brien SJ, Vogel stein B (1988) The GLI-Kruppel family of human
genes. Mol Cell Bioi 8:3104-3113
Ruppert JM, Vogelstein B, Arheden K, Kinzler KW (1990) GLI3 encodes a
190-kilodalton protein with multiple regions of GLI similarity. Mol Cell
Bioi 10:5408-5415
Sisson JC, Ho KS, Suyama K, Scott MP (1997) Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90:235-245
Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott
MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper IE, de Sauvage F,