230
E. C. Bailey et al.
Incardona JP, Gaffield W, Kapur RP, Roelink H (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125:3553-3562
Ingham PW, Taylor AM, Nakano Y (1991) Role of the Drosophila patched
gene in positional signalling. Nature 353: 184-187
Jiang J, Struhl G (1995) Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80:563-572
Jiang J, Struhl G (1998) Regulation of the Hedgehog and Wingless signalling
pathways by the F- boxIWD40-repeat protein Slimb. Nature 391:493-496
Jingami H, Brown MS, Goldstein JL, Anderson RG, Luskey KL (1987) Partial
deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. J Cell BioI 104: 1693-1704
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn
AG, Myers RM, Cox DR, Epstein E Jr, Scott MP (1996) Human homolog
of patched, a candidate gene for the basal cell nevus syndrome. Science
272:1668-1671
Kang S, Graham J, Jr., Olney AH, Biesecker LG (1997) GLI3 frameshift mutations
cause autosomal dominant Pallister-Hall syndrome. Nat Genet 15:266--268
Keeler RF (1975) Teratogenic effects of cyclopamine and jervine in rats, mice
and hamsters. Proc Soc Exp BioI Med 149:302-306
Keeler RF (1978) Cyclopamine and related steroidal alkaloid teratogens: their
occurrence, structural relationship, and biologic effects. Lipids 13:708-715
Kim SK, Melton DA (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Nat! Acad Sci USA
95:13036-13041
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Wong
AJ, Vogelstein B (1987) Identification of an amplified, highly expressed
gene in a human glioma. Science 236:70-73
Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B (1988) The GLI gene is a
member of the Kruppel family of zinc finger proteins. Nature 332:371-374
Kumagai H, Chun KT, Simoni RD (1995) Molecular dissection of the role of
the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J BioI Chern 270:19107-19113
Lee n, von Kessler DP, Parks S, Beachy PA (1992) Secretion and localized
transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71:33-50
Lee n, Ekker SC, von Kessler DP, Porter JA, Sun BI, Beachy PA (1994) Autoproteolysis in hedgehog protein biogenesis. Science 266: 1528-1537
Lepage T, Cohen SM, Diaz-Benjumea FJ, Parkhurst SM (1995) Signal
transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373:711-715
E. C. Bailey et al.
Incardona JP, Gaffield W, Kapur RP, Roelink H (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125:3553-3562
Ingham PW, Taylor AM, Nakano Y (1991) Role of the Drosophila patched
gene in positional signalling. Nature 353: 184-187
Jiang J, Struhl G (1995) Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80:563-572
Jiang J, Struhl G (1998) Regulation of the Hedgehog and Wingless signalling
pathways by the F- boxIWD40-repeat protein Slimb. Nature 391:493-496
Jingami H, Brown MS, Goldstein JL, Anderson RG, Luskey KL (1987) Partial
deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum. J Cell BioI 104: 1693-1704
Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn
AG, Myers RM, Cox DR, Epstein E Jr, Scott MP (1996) Human homolog
of patched, a candidate gene for the basal cell nevus syndrome. Science
272:1668-1671
Kang S, Graham J, Jr., Olney AH, Biesecker LG (1997) GLI3 frameshift mutations
cause autosomal dominant Pallister-Hall syndrome. Nat Genet 15:266--268
Keeler RF (1975) Teratogenic effects of cyclopamine and jervine in rats, mice
and hamsters. Proc Soc Exp BioI Med 149:302-306
Keeler RF (1978) Cyclopamine and related steroidal alkaloid teratogens: their
occurrence, structural relationship, and biologic effects. Lipids 13:708-715
Kim SK, Melton DA (1998) Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Nat! Acad Sci USA
95:13036-13041
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Wong
AJ, Vogelstein B (1987) Identification of an amplified, highly expressed
gene in a human glioma. Science 236:70-73
Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B (1988) The GLI gene is a
member of the Kruppel family of zinc finger proteins. Nature 332:371-374
Kumagai H, Chun KT, Simoni RD (1995) Molecular dissection of the role of
the membrane domain in the regulated degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J BioI Chern 270:19107-19113
Lee n, von Kessler DP, Parks S, Beachy PA (1992) Secretion and localized
transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71:33-50
Lee n, Ekker SC, von Kessler DP, Porter JA, Sun BI, Beachy PA (1994) Autoproteolysis in hedgehog protein biogenesis. Science 266: 1528-1537
Lepage T, Cohen SM, Diaz-Benjumea FJ, Parkhurst SM (1995) Signal
transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373:711-715