223
Mammalian 15-LOX oxidizes linoleic acid and plant LOX oxidizes arachidonic
acid. In this aspect we can conclude that soyabean lipoxygenase is similar to mammalian 15-LOX in many aspects, hence LOX inhibitors from plants may be beneficial for the development of new drugs to manage diseases related to arachidonic
acid metabolism.
O
H
H
O
O
HO
O
O
O
O
O
HO
HO
Phenethyl-Trans-Ferulate
Cryptotanshinone
Senkyunolide O
Roburic Acid
Betulinic Acid
Beta –boswellic acid
Acetyl beta- boswellic acid
Acetyl alpha- -boswellic acid
Acetyl-11-keto-beta-boswellic acid
O
OMe
HO
O
H
H
H
O
O
O
HO
H
H
H
H
O
OH
OH
O
O
O
CH 3
CH 3
H 3 C
HO
O
H 3 C
O
O
COOH
H 3 C
H 3 C
CH 3
CH 3
CH 3
CH 3
CH 3
O
O
OH
Fig. 9.27 Natural
cyclooxygenase inhibitors
9 Anti-inflammatory Molecules: Enzyme Inhibitors
Mammalian 15-LOX oxidizes linoleic acid and plant LOX oxidizes arachidonic
acid. In this aspect we can conclude that soyabean lipoxygenase is similar to mammalian 15-LOX in many aspects, hence LOX inhibitors from plants may be beneficial for the development of new drugs to manage diseases related to arachidonic
acid metabolism.
O
H
H
O
O
HO
O
O
O
O
O
HO
HO
Phenethyl-Trans-Ferulate
Cryptotanshinone
Senkyunolide O
Roburic Acid
Betulinic Acid
Beta –boswellic acid
Acetyl beta- boswellic acid
Acetyl alpha- -boswellic acid
Acetyl-11-keto-beta-boswellic acid
O
OMe
HO
O
H
H
H
O
O
O
HO
H
H
H
H
O
OH
OH
O
O
O
CH 3
CH 3
H 3 C
HO
O
H 3 C
O
O
COOH
H 3 C
H 3 C
CH 3
CH 3
CH 3
CH 3
CH 3
O
O
OH
Fig. 9.27 Natural
cyclooxygenase inhibitors
9 Anti-inflammatory Molecules: Enzyme Inhibitors