222
[8]-paradol and [8]-shogaol, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl) decane
and 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl) dodecane. 6-Shogaol (IC 50 –2.1
μm), 10-Gingerol (IC 50 –32.0 ± 1.5 μM), 6-Gingerol (IC 50 > 50 μm), 8-Gingerol
(IC 50 –10 μm) also have same inhibitory effect on Cycloxygenase (Van Breemen
et al. 2011) (Fig. 9.28).
9.2.3 Lipoxygenase Inhibitors
Arachidonic acid metabolites like leukotrienes are produced via lipoxygenase pathway. Mammalian LOX are generally classified into five types based on the oxidation of arachidonic acid, and they are 5-LOX, 8-LOX, 11-LOX, 12-LOX and
15-LOX. Arachidonic acid and linoleic acid are the natural substrates of
LOX. Linoleic acid is the standard substrate for plant LOX, whereas arachidonic
acid is considered as the substrate for mammalian LOX. Hydroperoxides of these
substrate are the major products.
O
O
O
O
O
O
O
O
OH
O
OH
OH
OH
OH
OH
OH
OH
OH
O
O
O
O
O
O
OH
O
OH
OH
O
O
HO
HO
HO
HO
HO
OH
OH
OH
OH
HO
HO
HO
HO
OH
HO
Prenylated Flavonoids
Morusin
Kuwanon C
Kazinol B
Kuraridin
Sanggenon D
Sophoraisoflavanone
Fig. 9.26 Natural prenylated flavonoids as cyclooxygenase inhibitor
C.S. Sharanya and M. Haridas