210
2-methoxycyclohexa-2-5-diene-1,4-dione with PLA 2 has been described by Dileep
et al. (2013) at a resolution of 2.5 Å. 1-Naphthalene acetic acid and dibutyl benzene1,2-dicarboxylate dibutyl phthalate also binds at the entry of active site and inhibits
the entry of substrate, thus it may act as a good anti-inflammatory lead molecule
(Figs. 9.9 and 9.10).
9.2.2 Cyclooxygenase Inhibitors
Cyclooxygenase is the enzyme which primarily transforms Arachidonic acid into
unstable prostaglandin G 2 (PGG 2 ) via the oxygenase function, then to the more
stable prostaglandin H 2 (PGH 2 ) via the peroxidase function, and is therefore known
as prostaglandin H synthase (PGHS) (Meirer et al. 2014). This is a
Fig. 9.9 PLA 2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione (3HSW) and naphthalene acetic acid (4O1Y)
Fig. 9.10 PLA 2 in
complex dibutyl benzene1,2-dicarboxylate dibutyl
phthalate (4G5I)
C.S. Sharanya and M. Haridas
2-methoxycyclohexa-2-5-diene-1,4-dione with PLA 2 has been described by Dileep
et al. (2013) at a resolution of 2.5 Å. 1-Naphthalene acetic acid and dibutyl benzene1,2-dicarboxylate dibutyl phthalate also binds at the entry of active site and inhibits
the entry of substrate, thus it may act as a good anti-inflammatory lead molecule
(Figs. 9.9 and 9.10).
9.2.2 Cyclooxygenase Inhibitors
Cyclooxygenase is the enzyme which primarily transforms Arachidonic acid into
unstable prostaglandin G 2 (PGG 2 ) via the oxygenase function, then to the more
stable prostaglandin H 2 (PGH 2 ) via the peroxidase function, and is therefore known
as prostaglandin H synthase (PGHS) (Meirer et al. 2014). This is a
Fig. 9.9 PLA 2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione (3HSW) and naphthalene acetic acid (4O1Y)
Fig. 9.10 PLA 2 in
complex dibutyl benzene1,2-dicarboxylate dibutyl
phthalate (4G5I)
C.S. Sharanya and M. Haridas