209
compound supports the rigorous use of medicated oils rich in n-hexadecanoic acid
and similar fatty acids for the treatment of rheumatic symptoms in the traditional
medical system of India, Ayurveda. Inhibition studies of curcumin with PLA 2 also
gave remarkable results. Crystal structure of photodegraded product of curcumin
O
R
1
R
2
N
R1
R2
IC 50 (mM)
13.6 ± 4.2
0.84 ± 0.17
0.26 ± 0.11
COOH
CH 3
CH 3
CH 2 CH 3
CONH 2
CONH 2
Fig. 9.6 Indole derivatives
Fig. 9.7 PLA 2 in complex with Berberine (2QVD) and dihydroxyberberine (3 L30)
Fig. 9.8 PLA 2 in complex with catechol (3O4M) and n-hexadecanoic acid (3QLM)
9 Anti-inflammatory Molecules: Enzyme Inhibitors
compound supports the rigorous use of medicated oils rich in n-hexadecanoic acid
and similar fatty acids for the treatment of rheumatic symptoms in the traditional
medical system of India, Ayurveda. Inhibition studies of curcumin with PLA 2 also
gave remarkable results. Crystal structure of photodegraded product of curcumin
O
R
1
R
2
N
R1
R2
IC 50 (mM)
13.6 ± 4.2
0.84 ± 0.17
0.26 ± 0.11
COOH
CH 3
CH 3
CH 2 CH 3
CONH 2
CONH 2
Fig. 9.6 Indole derivatives
Fig. 9.7 PLA 2 in complex with Berberine (2QVD) and dihydroxyberberine (3 L30)
Fig. 9.8 PLA 2 in complex with catechol (3O4M) and n-hexadecanoic acid (3QLM)
9 Anti-inflammatory Molecules: Enzyme Inhibitors