197
Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F,
Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD,
Oberlies NH, Wall ME, Wani MC (2007) Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa Haitiensis. J Nat Prod 70:954–961
Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH,
Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM (1995)
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1:1046–1051
Ramalakshmi C, Kalirajan A, Ranjitsingh AJA, Kalirajan K (2014) In vitro anticancer and antioxidant activity of the medicinal plant Couroupita guianensis. Int J Phyto Res 5:158–164
Reddy L, Odhav B, Bhoola KD (2003) Natural products for cancer prevention: a global perspective. Pharmacol Ther 99:1–13
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WGJ (1998) Crystal structure of human
topoisomerase I in covalent and noncovalent complexes with DNA. Science 279:1504–1513
Rekha PS, Kuttan G, Kuttan R (2001) Antioxidant activity of Brahma rasayana. Indian J Exp Biol
39:447–452
Roleira FMF, Elisiário J, Tavares-da-Silva, Varela CL et al (2015) Plant derived and dietary phenolic antioxidants: anticancer properties. Food Chem 183:235–258
Romero-Jimenez M, Campos-Sanchez J, Analla M, Munoz-Serrano A, Alonso-Moraga A
(2005) Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat Res
85:147–155
Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP (1992) Boswellic acids:
novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 261:1143–1146.
Safayhi H, Sabie Raj J, Sailer ER, Ammon HPT (1994) Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med 60:410–413
Safayhi H, Sailer ER, Ammon HP (1995) Mechanism of 5-lipoxygenase inhibition by acetyl-11keto-beta-boswellic acid. Mol Pharmacol 47:1212–1216
Sakarkar DM, Deshmukh VN (2011) Ethnopharmacological review of traditional medicinal plants
for anticancer activity. Int J Pharm Technol Res 3:298–308
Salla M, Isabelle F, Najat S, Nadine D, Hala GM (2013) Synergistic anticancer activities of the
plant-derived sesquiterpene lactones salograviolide a and iso-seco-tanapartholide. J Nat Med
67:468–479
Serraino M, Thompson LU (1991) The effect of flaxseed supplementation on early risk markers for
mammary carcinogenesis. Cancer Lett 60:135–142
Serraino M, Thompson LU (1992) The effect of flaxseed supplementation on the initiation and
promotional stages of mammary tumorigenesis. Nutr Cancer 17:153–159
Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT (1998) Inhibitory activity of boswellic
acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Med
64:328–331
Sharma M, Hudson JB, Adomat H, Guns E, Cox ME (2014) In vitro anticancer activity of plantderived cannabidiol on prostate cancer cell lines. Pharm Pharm 5:806–820
Shen CH, Shee JJ, Wu JY, Lin Y, Wu J, Liu Y (2010) Combretastatin A-4 inhibits cell growth and
metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder
tumour model. Br J Pharmacol 160:2008–2027
Shishodia S, Aggarwal BB (2004) Guggulsterone inhibits NF-κB and IκBα kinase activation,
suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem
279:47148–47158
Shohat B, Shaltiel A, Ben-Bassat M, Joshua H (1976) The effect of withaferin a, a natural steroidal
lactone, on the fine structure of S-180 tumor cells. Cancer Lett 2(2):71–78
Silva GL, Cui B, Chavez D, You M, Chai HB, Rasoanaivo P, Lynn SM, O’Neill MJ, Lewis JA,
Besterman JM, Monks A, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2001)
8 Cancer Combating Biomolecules From Plants
Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F,
Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD,
Oberlies NH, Wall ME, Wani MC (2007) Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa Haitiensis. J Nat Prod 70:954–961
Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH,
Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM (1995)
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1:1046–1051
Ramalakshmi C, Kalirajan A, Ranjitsingh AJA, Kalirajan K (2014) In vitro anticancer and antioxidant activity of the medicinal plant Couroupita guianensis. Int J Phyto Res 5:158–164
Reddy L, Odhav B, Bhoola KD (2003) Natural products for cancer prevention: a global perspective. Pharmacol Ther 99:1–13
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WGJ (1998) Crystal structure of human
topoisomerase I in covalent and noncovalent complexes with DNA. Science 279:1504–1513
Rekha PS, Kuttan G, Kuttan R (2001) Antioxidant activity of Brahma rasayana. Indian J Exp Biol
39:447–452
Roleira FMF, Elisiário J, Tavares-da-Silva, Varela CL et al (2015) Plant derived and dietary phenolic antioxidants: anticancer properties. Food Chem 183:235–258
Romero-Jimenez M, Campos-Sanchez J, Analla M, Munoz-Serrano A, Alonso-Moraga A
(2005) Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat Res
85:147–155
Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP (1992) Boswellic acids:
novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 261:1143–1146.
Safayhi H, Sabie Raj J, Sailer ER, Ammon HPT (1994) Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med 60:410–413
Safayhi H, Sailer ER, Ammon HP (1995) Mechanism of 5-lipoxygenase inhibition by acetyl-11keto-beta-boswellic acid. Mol Pharmacol 47:1212–1216
Sakarkar DM, Deshmukh VN (2011) Ethnopharmacological review of traditional medicinal plants
for anticancer activity. Int J Pharm Technol Res 3:298–308
Salla M, Isabelle F, Najat S, Nadine D, Hala GM (2013) Synergistic anticancer activities of the
plant-derived sesquiterpene lactones salograviolide a and iso-seco-tanapartholide. J Nat Med
67:468–479
Serraino M, Thompson LU (1991) The effect of flaxseed supplementation on early risk markers for
mammary carcinogenesis. Cancer Lett 60:135–142
Serraino M, Thompson LU (1992) The effect of flaxseed supplementation on the initiation and
promotional stages of mammary tumorigenesis. Nutr Cancer 17:153–159
Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT (1998) Inhibitory activity of boswellic
acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Med
64:328–331
Sharma M, Hudson JB, Adomat H, Guns E, Cox ME (2014) In vitro anticancer activity of plantderived cannabidiol on prostate cancer cell lines. Pharm Pharm 5:806–820
Shen CH, Shee JJ, Wu JY, Lin Y, Wu J, Liu Y (2010) Combretastatin A-4 inhibits cell growth and
metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder
tumour model. Br J Pharmacol 160:2008–2027
Shishodia S, Aggarwal BB (2004) Guggulsterone inhibits NF-κB and IκBα kinase activation,
suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem
279:47148–47158
Shohat B, Shaltiel A, Ben-Bassat M, Joshua H (1976) The effect of withaferin a, a natural steroidal
lactone, on the fine structure of S-180 tumor cells. Cancer Lett 2(2):71–78
Silva GL, Cui B, Chavez D, You M, Chai HB, Rasoanaivo P, Lynn SM, O’Neill MJ, Lewis JA,
Besterman JM, Monks A, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2001)
8 Cancer Combating Biomolecules From Plants