Smart polymers, 373
Snake venom, 106
S N 2-borderline, 123
reaction, 241
Sobrerol, 356
Soft drinks, 108
Sol-gel process, 374
Solid support, 369
Solvation-substitution theory, 15
D-Sorbitol, 169
L-Sorbose, 169
Soybean, 194
Sphingobium, 146
Sphingomonas sp., 361
Starch, 371
Statin, 215, 261, 336
Steam-cracking, 412
Steapsin, 87, 90
Stereo complementary, 158, 247
Stereoinversion, 154–156
Steric requirements, 87
Steroids, 9, 178
Stetter reactions, 4, 233
Strecker
reactions, 157
synthesis, 131
Streptavidin, 383
Streptomyces sp, 158
Structural water, 11, 316, 319
Styrene, 198
monooxygenase, 185
oxide, 120
Substrate channelling, 367
engineering, 73–74
model, 82, 143, 181
modification, 147, 153, 181
size, 141
type, 59, 84
Subtilisin, 52, 59, 70, 85, 316, 340, 382
Sucrose, 238
phosphorylase, 239
Sugar-1-phosphate, 236
Sulfatases, 409
Sulfenic, 126
Sulfhydryl residue, 126
Sulfinic, 126
Sulfone, 186
Sulfoxidation, 186–189, 202–204
Supercritical gases, 324–325
Surface-modified enzymes, 380–381
Suzukiase, 384
Synthesis gas, 413
Synzymes, 379
T
Tandem-reaction, 358
Taxadiene, 9
Taxol, 228, 412
Taxus chinensis, 228
Telaprevir, 172
Telescoping, 358
Temperature, 7
Terpenoids, 9, 179
α–Terpineol, 225
Tert-butanol, 74
Tert-butyl hydroperoxide, 200
Tertiary structure, 11
Tetracyclins, 9
Tetrahydrofolate, 157
Thalidomide, 6
Theozyme, 388
Thermoanaerobacter ethanolicus, 146
Thermoanaerobium brockii alcohol
dehydrogenase (TBADH), 140
Thermodynamic approach, 349
control, 113, 242
Thermolysin, 52, 351
Thermomyces lanuginosus lipase, 101
Thermostable enzymes, 13
Thiamine, 218–224
diphosphate, 8, 24
Thiirane, 119
Thioacetals, 188
Thioesterase, 226
Thioesters, 33, 84
Thioether-oxidation, 133
Thiolactols, 337
Three-point attachment rule, 16–17
L-Threonine Aldolases, 216
α-Tocopherol, 179, 244
Toluene dioxygenase, 197
Tomato, 25
Total turnover number (TTN), 23, 101, 107,
134, 137
Tranexamic acid, 129–130
Transaminase, 245, 362, 363
Trans-cyanation, 232
glycosidases, 236
glycosylation, 242
Transition metal complex, 339, 340, 383
Transition state, 18
mimic, 387
Transketolase, 222–224
Trans-phosphorylation, 112, 113
Trehalose, 238
Triacylglycerols, 84
Triglycerides, 83
Index
433
Snake venom, 106
S N 2-borderline, 123
reaction, 241
Sobrerol, 356
Soft drinks, 108
Sol-gel process, 374
Solid support, 369
Solvation-substitution theory, 15
D-Sorbitol, 169
L-Sorbose, 169
Soybean, 194
Sphingobium, 146
Sphingomonas sp., 361
Starch, 371
Statin, 215, 261, 336
Steam-cracking, 412
Steapsin, 87, 90
Stereo complementary, 158, 247
Stereoinversion, 154–156
Steric requirements, 87
Steroids, 9, 178
Stetter reactions, 4, 233
Strecker
reactions, 157
synthesis, 131
Streptavidin, 383
Streptomyces sp, 158
Structural water, 11, 316, 319
Styrene, 198
monooxygenase, 185
oxide, 120
Substrate channelling, 367
engineering, 73–74
model, 82, 143, 181
modification, 147, 153, 181
size, 141
type, 59, 84
Subtilisin, 52, 59, 70, 85, 316, 340, 382
Sucrose, 238
phosphorylase, 239
Sugar-1-phosphate, 236
Sulfatases, 409
Sulfenic, 126
Sulfhydryl residue, 126
Sulfinic, 126
Sulfone, 186
Sulfoxidation, 186–189, 202–204
Supercritical gases, 324–325
Surface-modified enzymes, 380–381
Suzukiase, 384
Synthesis gas, 413
Synzymes, 379
T
Tandem-reaction, 358
Taxadiene, 9
Taxol, 228, 412
Taxus chinensis, 228
Telaprevir, 172
Telescoping, 358
Temperature, 7
Terpenoids, 9, 179
α–Terpineol, 225
Tert-butanol, 74
Tert-butyl hydroperoxide, 200
Tertiary structure, 11
Tetracyclins, 9
Tetrahydrofolate, 157
Thalidomide, 6
Theozyme, 388
Thermoanaerobacter ethanolicus, 146
Thermoanaerobium brockii alcohol
dehydrogenase (TBADH), 140
Thermodynamic approach, 349
control, 113, 242
Thermolysin, 52, 351
Thermomyces lanuginosus lipase, 101
Thermostable enzymes, 13
Thiamine, 218–224
diphosphate, 8, 24
Thiirane, 119
Thioacetals, 188
Thioesterase, 226
Thioesters, 33, 84
Thioether-oxidation, 133
Thiolactols, 337
Three-point attachment rule, 16–17
L-Threonine Aldolases, 216
α-Tocopherol, 179, 244
Toluene dioxygenase, 197
Tomato, 25
Total turnover number (TTN), 23, 101, 107,
134, 137
Tranexamic acid, 129–130
Transaminase, 245, 362, 363
Trans-cyanation, 232
glycosidases, 236
glycosylation, 242
Transition metal complex, 339, 340, 383
Transition state, 18
mimic, 387
Transketolase, 222–224
Trans-phosphorylation, 112, 113
Trehalose, 238
Triacylglycerols, 84
Triglycerides, 83
Index
433