Protein Data Bank (PDB) (cont.)
expression, 418
Proteus sp., 162
Protoporphyrin, 199
Proximal, 195
Pseudo-enantiomeric, 78
Pseudomonas aeruginosa, 247
lipase, 78
Pseudomonas oleovorans, 184
putida, 175, 197, 258
Pseudomonas sp. lipase, 96–98, 332, 333, 338
Psilocibin, 104
Pteridin, 175
Pyrazinamide, 128
Pyrenophorin, 343
Pyrethroids, 99, 229, 337
Pyrethrum, 231
Pyridoxal phosphate, 8, 24
Pyridoxal-5
0 -phosphate, 52, 245
Pyrococcus furiosus, 240
Pyrroloquinoline quinone (PQQ), 134, 355
Pyruvate, 139, 207, 214, 247, 364, 377
decarboxylase, 214, 220, 221
kinase, 107, 110, 360
Q
Quaternary ammonium salts, 324
structure, 11
Quercetin, 244
R
Rabbit muscle aldolase, 208
Racemases, 409
Racemic esters, 67–68
temperature, 75
Racemization, 48, 99, 131, 316, 346, 362
Raney-Ni, 74, 151, 346
Rate acceleration, 240
constants, 36, 40
Recycling, 355
Reduction, 133–167
Reductive, 139
amination, 133, 159, 248
half reaction, 162
Red yeasts, 120
Regioselective hydrolysis, 61–62, 129–130
phosphorylation, 109–111
protection, 341–342
Regioselectivity, 5
Reichardt–Dimroth polarity parameter, 320
Reichardt’s dye, 323
Renewable carbon feedstocks, 412
Repeated resolution, 47
Reporter group, 78
Resolution, 337–342
Resveratrol, 244
Retention, 117, 123, 240
Reversal of stereopreference, 64
Reverse hydrolysis, 113, 242
micelle, 375
Reversible reaction, 42–44
Rh, 250
Rhodococcus erythropolis, 156
Fe 2 -S 2 Rieske cluster, 196
Rieske-type iron dioxygenases, 196
Rivastigmine, 249
Robinson annulation, 388
Rosetta algorithm, 389
Rubredoxin reductase, 184
S
Safety categories, 415
Salicylaldehyde, 52
Salt bridges, 12, 77
hydrates, 322
Saturation mutagenesis, 78
Schiff base, 53, 124, 133, 205, 216, 235, 245,
329, 371
Secondary
metabolism, 25
metabolites, 9
structure, 11
Selectivity, 36
enhancement, 147
factor, 39
Selenium, 199
Semisynthetic peroxidase, 382
Sephadex, 370
Sequential resolution, 44
Serine ester hydrolases, 59
Serine hydrolases, 32
SF 6 , 324
Shaking, 84
Sharpless epoxidation, 115, 336
Shear forces, 416
Sialic acid aldolase, 214
Side-on complex, 196
Siderophores, 157
Silica, 374
Simvastatin, 179
Single-step kinetics, 36
SI system, 22
Sitagliptin, 249
432
Index
expression, 418
Proteus sp., 162
Protoporphyrin, 199
Proximal, 195
Pseudo-enantiomeric, 78
Pseudomonas aeruginosa, 247
lipase, 78
Pseudomonas oleovorans, 184
putida, 175, 197, 258
Pseudomonas sp. lipase, 96–98, 332, 333, 338
Psilocibin, 104
Pteridin, 175
Pyrazinamide, 128
Pyrenophorin, 343
Pyrethroids, 99, 229, 337
Pyrethrum, 231
Pyridoxal phosphate, 8, 24
Pyridoxal-5
0 -phosphate, 52, 245
Pyrococcus furiosus, 240
Pyrroloquinoline quinone (PQQ), 134, 355
Pyruvate, 139, 207, 214, 247, 364, 377
decarboxylase, 214, 220, 221
kinase, 107, 110, 360
Q
Quaternary ammonium salts, 324
structure, 11
Quercetin, 244
R
Rabbit muscle aldolase, 208
Racemases, 409
Racemic esters, 67–68
temperature, 75
Racemization, 48, 99, 131, 316, 346, 362
Raney-Ni, 74, 151, 346
Rate acceleration, 240
constants, 36, 40
Recycling, 355
Reduction, 133–167
Reductive, 139
amination, 133, 159, 248
half reaction, 162
Red yeasts, 120
Regioselective hydrolysis, 61–62, 129–130
phosphorylation, 109–111
protection, 341–342
Regioselectivity, 5
Reichardt–Dimroth polarity parameter, 320
Reichardt’s dye, 323
Renewable carbon feedstocks, 412
Repeated resolution, 47
Reporter group, 78
Resolution, 337–342
Resveratrol, 244
Retention, 117, 123, 240
Reversal of stereopreference, 64
Reverse hydrolysis, 113, 242
micelle, 375
Reversible reaction, 42–44
Rh, 250
Rhodococcus erythropolis, 156
Fe 2 -S 2 Rieske cluster, 196
Rieske-type iron dioxygenases, 196
Rivastigmine, 249
Robinson annulation, 388
Rosetta algorithm, 389
Rubredoxin reductase, 184
S
Safety categories, 415
Salicylaldehyde, 52
Salt bridges, 12, 77
hydrates, 322
Saturation mutagenesis, 78
Schiff base, 53, 124, 133, 205, 216, 235, 245,
329, 371
Secondary
metabolism, 25
metabolites, 9
structure, 11
Selectivity, 36
enhancement, 147
factor, 39
Selenium, 199
Semisynthetic peroxidase, 382
Sephadex, 370
Sequential resolution, 44
Serine ester hydrolases, 59
Serine hydrolases, 32
SF 6 , 324
Shaking, 84
Sharpless epoxidation, 115, 336
Shear forces, 416
Sialic acid aldolase, 214
Side-on complex, 196
Siderophores, 157
Silica, 374
Simvastatin, 179
Single-step kinetics, 36
SI system, 22
Sitagliptin, 249
432
Index