Metabolic engineering (cont.)
pathways, 367
Metagenome, 131
Metal catalyst, 97
ions, 13
Metalloenzymes, 382
Metal-porphyrins, 24
Metathase, 384
Methoxyacetate, 345
Methylene bromide, 250
Micelles, 375–378
Michael-addition, 233
Michaelis-Menten, 83
kinetics, 39
Michael-type addition, 162
Microbial cells, 69
epoxide hydrolases, 119–124
esterases, 68–70
Microemulsions, 324
Micro-pH, 325
Microwave (MW), 76
Mild Hydrolysis, 61
MIO cofactor, 228
Mirror-image enzymes, 7
orientation, 86
Mitsunobu intermediate, 47
inversions, 4
Mn tricarbonyl complex, 142
Modified enzymes, 379–385
Molecular
dynamics, 81
lubricant, 317, 322
modeling, 80
sieves, 325
Monoamine, 171
Monooxygenases, 116, 173–178, 186, 191
Monophasic, 317–318
Morphinan, 103
Mucor sp. lipases, 86, 98–102
Mutability, 26
Mutant libraries, 77
Myristyl myristate, 326
N
NAD
+ , 355
NADPH, 24, 136, 162
Naphthalene dioxygenase, 196
Naproxen, 69, 132
NDP-sugar, 237
Nef reactions, 4
Nernst distribution, 320
Nerolidol, 226
Nicotinamide, 8, 128
Nicotinamide adenine dinucleotide (NAD), 134
Nicotinamide oxidases, 139
Niraparib, 250
Nitric oxide (NO), 126
Nitrilases, 126
Nitrile hydratase, 126
Nitrite, 124, 260
Nitroalkenes, 163, 232, 233
Nitro-olefins, 165
p-Nitrophenyl derivatives, 78
Nocardia corallina, 185
Nojirimycin, 209
Nitrilases, 362
Nucleophile, 32, 260, 337, 348
N-Nucleophiles, 344
Nucleoside diphosphate sugar, 236
Nucleotides, 110
O
Oils, 413
Old yellow enzyme, 161
Oleate hydratases, 225
Optimization of Selectivity, 72–73, 102
o-Quinone, 182
Organic
cosolvents, 75, 232
dyes, 139
media, 316
solvent, 102, 183, 356
Organometallic, 148, 335
Ornithine, 248
Orotidine monophosphate (O-5-P), 110
ortho-ester, 341
Osmolytes, 239
Over-reduction, 164
Oxaloacetate, 79
Oxalocrotonate, 234
tautomerase, 234
Oxazolones, 353
Oxidase, 133, 171, 173
Oxidation, 167
β–Oxidation, 180
Oxidation of alcohols and aldehydes, 168–171
of amines, 171–172
of Polyols, 169
state, 412
Oxidative coupling, 201
half reaction, 162
Oxophytodienoic acid reductase, 164
430
Index