174
F. Glorius, K. Hirano
Scheme 14. Intramolecular reactions using an ether linkage
Scheme 15. Intramolecular reactions
8
Formation of β-Lactones
Not only can this umpolung reaction be used to form 5-membered γbutyrolactones, but 4-membered β-lactones can be formed also. Interestingly, this change does not rely on a change of catalyst, but rather the
reaction conditions are crucial for the reaction outcome. Using the same
substrates and the same catalyst, but changing the base, the solvent and
the reaction temperature allowed a change of the outcome of this reaction. Under optimized reaction conditions, β-lactones 18 formed with
F. Glorius, K. Hirano
Scheme 14. Intramolecular reactions using an ether linkage
Scheme 15. Intramolecular reactions
8
Formation of β-Lactones
Not only can this umpolung reaction be used to form 5-membered γbutyrolactones, but 4-membered β-lactones can be formed also. Interestingly, this change does not rely on a change of catalyst, but rather the
reaction conditions are crucial for the reaction outcome. Using the same
substrates and the same catalyst, but changing the base, the solvent and
the reaction temperature allowed a change of the outcome of this reaction. Under optimized reaction conditions, β-lactones 18 formed with