100
D. Enders, M.R.M. Hüttl, O. Niemeier
Scheme 33. Asymmetric intramolecular crossed benzoin reaction
face of the Breslow intermediate (Breslow 1958), which is formed as its
E isomer in the hypothetical catalytic cycle, would be sterically shielded
by the tetrahydro naphthalene residue of the tetracyclic catalyst. The Re
face of the intermediate would attack the ketone function at its Re face
D. Enders, M.R.M. Hüttl, O. Niemeier
Scheme 33. Asymmetric intramolecular crossed benzoin reaction
face of the Breslow intermediate (Breslow 1958), which is formed as its
E isomer in the hypothetical catalytic cycle, would be sterically shielded
by the tetrahydro naphthalene residue of the tetracyclic catalyst. The Re
face of the intermediate would attack the ketone function at its Re face