6
S.C. Pan, B. List
Scheme 3. Proline-catalyzed asymmetric aldol reactions
Bøgevig et al. 2002a; Pidathala et al. 2003; Tokuda et al. 2005). Proline seems to be a fairly general, efficient, and enantioselective catalyst
of the aldol reaction and the substrate scope is still increasing continuously.
Both experimental and theoretical studies have contributed significantly to the elucidation of the reaction mechanism. We found that in
contrast with earlier proposals (Agami et al. 1984, 1986, 1988; Puchot
et al. 1986; Agami and Puchot 1986), proline-catalyzed aldol reactions
S.C. Pan, B. List
Scheme 3. Proline-catalyzed asymmetric aldol reactions
Bøgevig et al. 2002a; Pidathala et al. 2003; Tokuda et al. 2005). Proline seems to be a fairly general, efficient, and enantioselective catalyst
of the aldol reaction and the substrate scope is still increasing continuously.
Both experimental and theoretical studies have contributed significantly to the elucidation of the reaction mechanism. We found that in
contrast with earlier proposals (Agami et al. 1984, 1986, 1988; Puchot
et al. 1986; Agami and Puchot 1986), proline-catalyzed aldol reactions