Table 15.12. Genotoxic activity. Metaphase and anaphase chromosomal damage in
Ani/acTa physades early-developing embryos treated with bis(dimethyitin(IV)chioro)protoporphyrin(IX), adapted from Vitturi et
al. (1993)
Compound
Time
No. of embryos Total
Normal b
Abnormal
Total
concentration interval employed
spreads· metaphases
meta phases
spreads
(moldm-')
(h)
anaphases
anaphases
Fragments
Bridges
c
d
c
d
c
d
c
d
e
0.956 x 10- 5
24
11
220
10
2
59
3
46
10
104
18
98
48
9
180
8
48
2
36
14
80
16
84
2.07 X
10- 7
24
10
200
20
12
50
38
14
87
24
89
48
8
160
23
10
46
4
14
19
62
33
65
1 x 10- 9
24
12
240
63
59
10
5
9
24
78
78
84
48
8
160
35
42
13
5
10
48
52
60
Control
12
270
71
78
2
73
79
88
a
20 spreads per embryo were analysed.
b
The term "normal" indicates no difference from the control.
~ Number of metaphases.
Number of ana phases.
e
Number of prophases of which chromosome aberrations were not detected.
::::
00
..
"" ~
'"
. .
S·
?"
til
~
!:!.
?"
~
r;'
§'
0
~
(/)
.g
~
a:
0
"" ~
'"
. .
::1-'
0
H
'TI
o·
. .
'"
:-r1
::;l
o·
0'
Table 15.12. Genotoxic activity. Metaphase and anaphase chromosomal damage in
Anilocra physodes early-developing embryos treated with bis( dimethyltin{IV)chloro)protoporphyrin(IX), adapted from Vitturi et
al. (1993)
Compound
Time
No. of embryos Total
Normal b
Abnormal
Total
concentration interval
employed
spreads" metaphases
meta phases
spreads
(moldm-')
(h)
anaphases
anaphases
Fragments
Bridges
c
d
c
d
c
d
c
d
e
0.956
x 10- 5
24
11
220
10
2
59
3
46
10
104
18
98
48
9
180
8
48
2
36
14
80
16
84
2.07
x 10- 7
24
10
200
20
12
50
38
14
87
24
89
48
8
160
23
10
46
4
14
19
62
33
65
1 X
10- 9
24
12
240
63
59
10
5
9
24
78
78
84
48
8
160
35
42
13
5
10
48
52
60
Control
12
270
71
78
2
73
79
88
a
20 spreads per embryo were analysed.
b
The term 'normal' indicates no difference from the control.
~ Number of meta phases.
Number of anaphases.
e
Number of prophases of which chromosome aberrations were not detected.
::::
00
r"
' ""
~
'" ...
s"
?"
o:l
~
::l.
?"
~
it
~
0
~
(/)
.g
~
a:
\1
' ""
~
'"
...
::;:
0
H
'TI
o·
...
'"
""
::;l
o·
0
Ani/acTa physades early-developing embryos treated with bis(dimethyitin(IV)chioro)protoporphyrin(IX), adapted from Vitturi et
al. (1993)
Compound
Time
No. of embryos Total
Normal b
Abnormal
Total
concentration interval employed
spreads· metaphases
meta phases
spreads
(moldm-')
(h)
anaphases
anaphases
Fragments
Bridges
c
d
c
d
c
d
c
d
e
0.956 x 10- 5
24
11
220
10
2
59
3
46
10
104
18
98
48
9
180
8
48
2
36
14
80
16
84
2.07 X
10- 7
24
10
200
20
12
50
38
14
87
24
89
48
8
160
23
10
46
4
14
19
62
33
65
1 x 10- 9
24
12
240
63
59
10
5
9
24
78
78
84
48
8
160
35
42
13
5
10
48
52
60
Control
12
270
71
78
2
73
79
88
a
20 spreads per embryo were analysed.
b
The term "normal" indicates no difference from the control.
~ Number of metaphases.
Number of ana phases.
e
Number of prophases of which chromosome aberrations were not detected.
::::
00
..
"" ~
'"
. .
S·
?"
til
~
!:!.
?"
~
r;'
§'
0
~
(/)
.g
~
a:
0
"" ~
'"
. .
::1-'
0
H
'TI
o·
. .
'"
:-r1
::;l
o·
0'
Table 15.12. Genotoxic activity. Metaphase and anaphase chromosomal damage in
Anilocra physodes early-developing embryos treated with bis( dimethyltin{IV)chloro)protoporphyrin(IX), adapted from Vitturi et
al. (1993)
Compound
Time
No. of embryos Total
Normal b
Abnormal
Total
concentration interval
employed
spreads" metaphases
meta phases
spreads
(moldm-')
(h)
anaphases
anaphases
Fragments
Bridges
c
d
c
d
c
d
c
d
e
0.956
x 10- 5
24
11
220
10
2
59
3
46
10
104
18
98
48
9
180
8
48
2
36
14
80
16
84
2.07
x 10- 7
24
10
200
20
12
50
38
14
87
24
89
48
8
160
23
10
46
4
14
19
62
33
65
1 X
10- 9
24
12
240
63
59
10
5
9
24
78
78
84
48
8
160
35
42
13
5
10
48
52
60
Control
12
270
71
78
2
73
79
88
a
20 spreads per embryo were analysed.
b
The term 'normal' indicates no difference from the control.
~ Number of meta phases.
Number of anaphases.
e
Number of prophases of which chromosome aberrations were not detected.
::::
00
r"
' ""
~
'" ...
s"
?"
o:l
~
::l.
?"
~
it
~
0
~
(/)
.g
~
a:
\1
' ""
~
'"
...
::;:
0
H
'TI
o·
...
'"
""
::;l
o·
0