CHAPTER 15 . Toxic Effects of Organometallic Compounds towards Marine Biota
357
Exposure to lO -5 and lO -7 mol dm -3 bis( dimethyltin(IV)chloro )protoporphyrin(IX),
Fig. 15.16, of early developing embryos of Anilocra physodes 1. (Crustacea, Isopoda), a
parasite of various fish, for different exposure times, produced abnormal metaphase
and anaphase figures, which depended on the concentration and not the exposure time
(Vitturi et al. 1993) (Table 15.12).
According to the reported data, it may be concluded that the bis( dimethyltin(IV)chloro )protoporphyrin(IX) interferes with the formation of the mitotic spindle
and acts directly on metaphase chromosome structure (Vitturi et al. 1993).
The above-reported effects are also observed in embryos of the ascidian Ciona
intestinalis upon exposure to 10- 5 and 10- 7 mol dm -3 solutions of tributyltin(IV)chloride (Mansueto et al. 1993a).
o~
0
I
H3 C "....
CI
5nH3 C ~I
~
0,
0
o
o
H3 C "" .. I
f
N-H
H
~5n -CI
3
C
I
o
r
, N
/ N,
Fig. 15.16. Structure of bis( dimethyltin{IV)chloro )protoporphyrin(IX)
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I
H-N
,
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/
II