418
2
General Synthetic Methods
⊡ Scheme 69
⊡ Scheme 70
compounds 358 and 359 also form 356 under aerobic physiological conditions [282]. Reactive 352 combines reversibly with lysine and cysteine residues and irreversibly with arginine
residue [312] ( > Scheme 69).
L-threose (362), the degradation product of 360 degrades in the presence of N α -acetylL-lysine (369) at pH 7 into 3-deoxy-tetros-2-ulose (365) [313,314]. Only at pH 7 does retro-
2
General Synthetic Methods
⊡ Scheme 69
⊡ Scheme 70
compounds 358 and 359 also form 356 under aerobic physiological conditions [282]. Reactive 352 combines reversibly with lysine and cysteine residues and irreversibly with arginine
residue [312] ( > Scheme 69).
L-threose (362), the degradation product of 360 degrades in the presence of N α -acetylL-lysine (369) at pH 7 into 3-deoxy-tetros-2-ulose (365) [313,314]. Only at pH 7 does retro-