142 Marine Macro- and Microalgae: An Overview
Kong, C.S., J.A. Kim, N.Y. Yoon and S.K. Kim. 2009. Induction of apoptosis by phloroglucinol derivative from Ecklonia
cava in MCF-7 human breast cancer cells. Food Chem. Toxicol. 47: 1653–1658.
Kubanek, J., A.C. Prusak, T.W. Snell, R.A. Giese, C.R. Fairchild, W. Aalbersberg and M.E. Hay. 2006. Bromophycolides C-I
from the Fijian red alga Callophycus serratus. J. Nat. Prod. 69: 731–735.
Kuda, T., M. Tsunekawa, T. Hishi and Y. Araki. 2005. Antioxidant properties of dried ‘kayamo-nori’, a brown alga Scytosiphon
lomentaria (Scytosiphonales, Phaeophyceae). Food Chem. 89: 617–622.
Kumar, M., V. Gupta, P. Kumari, C.R.K. Reddy and B. Jha. 2011. Assessment of nutrient composition and antioxidant potential
of Caulerpaceae seaweeds. J. Food Comp. Anal. 24: 270–278.
Kurata, K., K. Tanguchi and M. Suzuki. 1996. Cyclozonarone, a sesquiterpene-substituted benzoquinone derivative from the
brown alga Dictyopteris undulata. Phytochemistry 41: 749–752.
Lakshmi, V., A.K. Goel, M.N. Srivastava, D.K. Kulshreshtha and R. Raghubir. 2006. Bioactive of marine organism - Part IX:
Screen of some marine flora from the Indian coasts. Indian J. Exp. Biol. 44: 137–141.
Laube, T., W. Beil and K. Seifert. 2005. Total synthesis of two 12-nordrimanes and the pharmacological active sesquiterpene
hydroquinone yahazunol. Tetrahedron 61: 1141–1148.
Lee, S.-H., C.-I. Ko, G. Ahn, S.G. You, J.-S. Kim, M.S. Heu, J. Kim, Y. Jee and Y.-J. Jeon. 2012. Molecular characteristics
and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava. Carbohyd. Polym. 89: 599–606.
León-Deniz, L.V., E. Dumonteil, R. Moo-Puc and Y. Freile-Pelegrin. 2009. Antitrypanosomal in vitro activity of tropical
marine algae extracts. Pharm. Biol. 47: 864–871.
Li, K., X.-M. Li, N.-Y. Ji and B.-G. Wang. 2007. Natural bromophenols from the marine red alga Polysiphonia urceolata
(Rhodomelaceae): structural elucidation and DPPH radical-scavenging activity. Bioorg. Med. Chem. 15: 6627–6631.
Li, Y., Z.-J. Qian, B. Ryu, S.-H. Lee, M.-M. Kim and S.-K. Kim. 2009. Chemical components and its antioxidant properties
in vitro: an edible marine brown alga, Ecklonia cava. Bioorg. Med. Chem. 7: 1963–1973.
Liu, M., P.E. Hansen and X. Lin. 2011. Bromophenols in marine algae and their bioactivities. Mar. Drugs 9: 1273–1292.
Manalo, D.J., A. Rowan, T. Lavoie, L. Natarajan, B.D. Kelly, S.Q. Ye, J.G. Garcia and G.L. Semenza. 2005. Transcriptional
regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659–669.
Manzanares, I., C. Cuevas, R. Garcia-Nieto, E. Marco and F. Gago. 2001. Advances in the chemistry and pharmacology of
ecteinascidins, a promising new class of anticancer agents. Curr. Med. Chem. Anticancer Agents 1: 257–276.
Maplestone, R.A., M.J. Stone and D.H. Williams. 1992. The evolutionary role of secondary metabolites—a review. Gene
115: 151–157.
Marcolino, M. 2010. Avaliação da atividade leishmanicida in vitro de heteropolissacarídeos ácidos: não sulfatados e naturalmente
sulfatados. M.S. Thesis, Universidade Federal do Paraná, Brasil.
Martín-Algarra, S., E. Espinosa, J. Rubió, J.J. López López, J.L. Manzano, L.A. Carrión, A. Plazaola, A. Tanovic and L.
Paz-Ares. 2009. Phase II study of weekly Kahalalide F in patients with advanced malignant melanoma. Eur. J. Cancer.
45: 732–735.
Mayer, A., A. Rodríguez, R. Berlinck and N. Fusetani. 2011. Marine pharmacology in 2007–8: Marine compounds with
antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral
activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action. Comp. Biochem.
Physiol. C Toxicol. Pharmacol. 153: 191–222.
Meinert, C.L. 2006. Clinical trials, overview. pp. 24–47. In: Sean Pidgeon (ed.). Wiley Handbook of Current and Emerging
Drug Therapies, Volumes 1–4. John Wiley & Sons, Hoboken, NJ.
Mendiola-Martínez, J., H. Hernández, D. Acuña, M. Esquivel, R.S. Lizama and J.A. Payrol. 2005. Inhibiting activity of the in
vitro growth of Plasmodium falciparum of extracts from algae of genus Laurencia. Rev. Cubana Med. Trop. 57: 192–5.
Mesulam, M., A. Guillozet, P. Shaw and B. Quinn. 2002. Widely spread butyrylcholinesterase can hydrolyze acetylcholine
in the normal and Alzheimer brain. Neurobiol. Dis. 9: 88–93.
Metting, F.B. 1996. Biodiversity and application of microalgae. J. Ind. Microbiol. 17: 477–489.
Miguel, M.G. 2010. Antioxidant and anti-inflammatory activities of essential oils: A short review. Molecules 15: 9252–9287.
Mohammed, K.A., C.F. Hossain, L. Zhang, R.K. Bruick, Y.D. Zhou and D.G. Nagle. 2004. Laurenditerpenol, a new diterpene
from the tropical marine alga Laurencia intricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor
cells. J. Nat. Prod. 67: 2002–2007.
Molinski, T.F., D.S. Dalisay, S.L. Lievens and J.P. Saludes. 2009. Drug development from marine natural products. Nat. Rev.
Drug Discov. 8: 69–85.
Moo-Puc, R., D. Robledo and Y. Freile-Pelegrin. 2008. Evaluation of selected tropical seaweeds for in vitro anti-trichomonal
activity. J. Ethnopharmacol. 120: 92–97.
Mukherjee, P.K., V. Kumar, M. Mal and P.J. Houghton. 2007. Acetylcholinesterase inhibitors from plants. Phytomedicine
14: 289–300.
Myung, C.-S., H.-C. Shin, H.Y. Bao, S.J. Yeo, B.H. Lee and J.S. Kang. 2005. Improvement of memory by dieckol and
phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Arch.
Pharm. Res. 28: 691–698.
Nahas, R., D. Abatis, M. Anagnostopoulou, P. Kefalas, C. Vagias and V. Roussis. 2007. Radical-scavenging activity of Aegean
Sea marine algae. Food Chem. 102: 577–581.
Kong, C.S., J.A. Kim, N.Y. Yoon and S.K. Kim. 2009. Induction of apoptosis by phloroglucinol derivative from Ecklonia
cava in MCF-7 human breast cancer cells. Food Chem. Toxicol. 47: 1653–1658.
Kubanek, J., A.C. Prusak, T.W. Snell, R.A. Giese, C.R. Fairchild, W. Aalbersberg and M.E. Hay. 2006. Bromophycolides C-I
from the Fijian red alga Callophycus serratus. J. Nat. Prod. 69: 731–735.
Kuda, T., M. Tsunekawa, T. Hishi and Y. Araki. 2005. Antioxidant properties of dried ‘kayamo-nori’, a brown alga Scytosiphon
lomentaria (Scytosiphonales, Phaeophyceae). Food Chem. 89: 617–622.
Kumar, M., V. Gupta, P. Kumari, C.R.K. Reddy and B. Jha. 2011. Assessment of nutrient composition and antioxidant potential
of Caulerpaceae seaweeds. J. Food Comp. Anal. 24: 270–278.
Kurata, K., K. Tanguchi and M. Suzuki. 1996. Cyclozonarone, a sesquiterpene-substituted benzoquinone derivative from the
brown alga Dictyopteris undulata. Phytochemistry 41: 749–752.
Lakshmi, V., A.K. Goel, M.N. Srivastava, D.K. Kulshreshtha and R. Raghubir. 2006. Bioactive of marine organism - Part IX:
Screen of some marine flora from the Indian coasts. Indian J. Exp. Biol. 44: 137–141.
Laube, T., W. Beil and K. Seifert. 2005. Total synthesis of two 12-nordrimanes and the pharmacological active sesquiterpene
hydroquinone yahazunol. Tetrahedron 61: 1141–1148.
Lee, S.-H., C.-I. Ko, G. Ahn, S.G. You, J.-S. Kim, M.S. Heu, J. Kim, Y. Jee and Y.-J. Jeon. 2012. Molecular characteristics
and anti-inflammatory activity of the fucoidan extracted from Ecklonia cava. Carbohyd. Polym. 89: 599–606.
León-Deniz, L.V., E. Dumonteil, R. Moo-Puc and Y. Freile-Pelegrin. 2009. Antitrypanosomal in vitro activity of tropical
marine algae extracts. Pharm. Biol. 47: 864–871.
Li, K., X.-M. Li, N.-Y. Ji and B.-G. Wang. 2007. Natural bromophenols from the marine red alga Polysiphonia urceolata
(Rhodomelaceae): structural elucidation and DPPH radical-scavenging activity. Bioorg. Med. Chem. 15: 6627–6631.
Li, Y., Z.-J. Qian, B. Ryu, S.-H. Lee, M.-M. Kim and S.-K. Kim. 2009. Chemical components and its antioxidant properties
in vitro: an edible marine brown alga, Ecklonia cava. Bioorg. Med. Chem. 7: 1963–1973.
Liu, M., P.E. Hansen and X. Lin. 2011. Bromophenols in marine algae and their bioactivities. Mar. Drugs 9: 1273–1292.
Manalo, D.J., A. Rowan, T. Lavoie, L. Natarajan, B.D. Kelly, S.Q. Ye, J.G. Garcia and G.L. Semenza. 2005. Transcriptional
regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659–669.
Manzanares, I., C. Cuevas, R. Garcia-Nieto, E. Marco and F. Gago. 2001. Advances in the chemistry and pharmacology of
ecteinascidins, a promising new class of anticancer agents. Curr. Med. Chem. Anticancer Agents 1: 257–276.
Maplestone, R.A., M.J. Stone and D.H. Williams. 1992. The evolutionary role of secondary metabolites—a review. Gene
115: 151–157.
Marcolino, M. 2010. Avaliação da atividade leishmanicida in vitro de heteropolissacarídeos ácidos: não sulfatados e naturalmente
sulfatados. M.S. Thesis, Universidade Federal do Paraná, Brasil.
Martín-Algarra, S., E. Espinosa, J. Rubió, J.J. López López, J.L. Manzano, L.A. Carrión, A. Plazaola, A. Tanovic and L.
Paz-Ares. 2009. Phase II study of weekly Kahalalide F in patients with advanced malignant melanoma. Eur. J. Cancer.
45: 732–735.
Mayer, A., A. Rodríguez, R. Berlinck and N. Fusetani. 2011. Marine pharmacology in 2007–8: Marine compounds with
antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral
activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action. Comp. Biochem.
Physiol. C Toxicol. Pharmacol. 153: 191–222.
Meinert, C.L. 2006. Clinical trials, overview. pp. 24–47. In: Sean Pidgeon (ed.). Wiley Handbook of Current and Emerging
Drug Therapies, Volumes 1–4. John Wiley & Sons, Hoboken, NJ.
Mendiola-Martínez, J., H. Hernández, D. Acuña, M. Esquivel, R.S. Lizama and J.A. Payrol. 2005. Inhibiting activity of the in
vitro growth of Plasmodium falciparum of extracts from algae of genus Laurencia. Rev. Cubana Med. Trop. 57: 192–5.
Mesulam, M., A. Guillozet, P. Shaw and B. Quinn. 2002. Widely spread butyrylcholinesterase can hydrolyze acetylcholine
in the normal and Alzheimer brain. Neurobiol. Dis. 9: 88–93.
Metting, F.B. 1996. Biodiversity and application of microalgae. J. Ind. Microbiol. 17: 477–489.
Miguel, M.G. 2010. Antioxidant and anti-inflammatory activities of essential oils: A short review. Molecules 15: 9252–9287.
Mohammed, K.A., C.F. Hossain, L. Zhang, R.K. Bruick, Y.D. Zhou and D.G. Nagle. 2004. Laurenditerpenol, a new diterpene
from the tropical marine alga Laurencia intricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor
cells. J. Nat. Prod. 67: 2002–2007.
Molinski, T.F., D.S. Dalisay, S.L. Lievens and J.P. Saludes. 2009. Drug development from marine natural products. Nat. Rev.
Drug Discov. 8: 69–85.
Moo-Puc, R., D. Robledo and Y. Freile-Pelegrin. 2008. Evaluation of selected tropical seaweeds for in vitro anti-trichomonal
activity. J. Ethnopharmacol. 120: 92–97.
Mukherjee, P.K., V. Kumar, M. Mal and P.J. Houghton. 2007. Acetylcholinesterase inhibitors from plants. Phytomedicine
14: 289–300.
Myung, C.-S., H.-C. Shin, H.Y. Bao, S.J. Yeo, B.H. Lee and J.S. Kang. 2005. Improvement of memory by dieckol and
phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Arch.
Pharm. Res. 28: 691–698.
Nahas, R., D. Abatis, M. Anagnostopoulou, P. Kefalas, C. Vagias and V. Roussis. 2007. Radical-scavenging activity of Aegean
Sea marine algae. Food Chem. 102: 577–581.