Marine Algal Bioactivities 141
Genovese, G., L. Tedone, M. Hamann and M. Morabito. 2009. The mediterranean red alga Asparagopsis: A source of compounds
against Leishmania. Mar. Drugs 7: 361–366.
Govindan, M., S.A. Abbas, E.I. Schmitz, R.H. Lee, I.S. Papkoff and D.L. Slate. 1994. New cycloartanol sulfates from the alga
Tydemania expeditionis: inhibitor of the protein tyrosin kinase pp60. J. Nat. Prod. 57: 74–78.
Gross, H., D.E. Goeger, P. Hills, S.L. Mooberry, D.L. Ballantine, T.F. Murray, F.A. Valeriote and W.H. Gerwick. 2006.
Lophocladines, bioactive alkaloids from the red alga Lophocladia sp. J. Nat. Prod. 69: 640–644.
Guardia, S.D., R. Valls, V. Mesguiche, J.-M. Brunei and G. Gulioli. 1999. Enantioselective synthesis of (–)-bifuracadiol: a
natural antitumor marine product. Tetrahedron Lett. 40: 8359–8360.
Guedes, A.C., H.M. Amaro and F.X. Malcata. 2011. Microalgae as sources of high added-value compounds—a brief review
of recent work. Biotechnol. Prog. 27: 597–613.
Gulioli, G., A. Oratalo-Magne, M. Daoudi, H. Thomas Guyon, R. Vallis and L. Piovetti. 2004. Trihydroxylated linear diterpenes
from the brown alga Bifurcaria bifurcata. Phytochemistry 65: 2063–2069.
Güven, K.C., A. Percot and E. Sezik. 2010. Alkaloids in marine algae. Mar. Drugs 8: 269–284.
Haefner, B. 2003. Drugs from the deep: marine natural products as drug candidates. Drug Discov. Today 8: 536–544.
Hamann, M.T. and P.J. Scheuer. 1993. Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens
and the green alga Bryopsis sp. J. Am. Chem. Soc. 115: 5825–5826.
Henríquez, R., G. Faircloth and C. Cuevas. 2005. Ecteinascidin 743 (ET-743, Yondelis), aplidin and kahalalide F. In:
G.M. Cragg, D.G.I. Kingston and D.J. Newman (eds.). Anticancer Agents from Natural Products. Taylor and Francis,
Boca Raton, Florida.
Heo, S.-J. and Y.-J. Jeon. 2009. Evaluation of diphlorethohydroxycarmalol isolated from Ishige okamurae for radical scavenging
activity and its protective effect against H 2 O 2 -induced cell damage. Process Biochem. 44: 412–418.
Heo, S.-J., W.-J. Yoon, K.-N. Kim, G.-N. Ahn, S.-M. Kang, D.-H. Kang, A. Affan, C. Oh, W.-K. Jung and Y.-J. Jeon. 2010.
Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW
264.7 macrophages. Food Chem. Toxicol. 48: 2045–2051.
Higuera-Ciapara, I., L. Félix-Valenzuela and M. Goycoolea. 2006. Astaxanthin: a review of its chemistry and applications.
Crit. Rev. Food Sci. 46: 185–196.
Honer, W.G. 2003. Pathology of presynaptic proteins in Alzheimer’s disease: more than simple loss of terminals. Neurobiol.
Aging 24: 1047–1062.
Huang, H.L., S.L. Wu, H.F. Liao, C.M. Jiang, R.L. Huang, Y.Y. Chen, Y.C. Yang and Y.J. Chen. 2005. Induction of apoptosis
by three marine algae through generation of reactive oxygen species in human leukemic cell lines. J. Agric. Food.
Chem. 53: 1776–1781.
Ishitsuka, O.M., T. Kusumi and H. Kakisawa H. 1988. Antitumor xenicane and norxenicane lactones from the brown algae
Dictyota dichotoma. J. Org. Chem. 53: 5010–5013.
Jaswir, I. and H.A. Monsur. 2011. Anti-inflammatory compounds of macro algae origin: A review. J. Med. Plants Res. 5:
7146–7154.
Jimeno, J., G. Faircloth, J.M. Fernández Sousa-Faro, P. Scheuer and K. Rinehart. 2004. New marine derived anticancer
therapeutics—a journey from the sea to clinical trials. Mar. Drugs 2: 14–29.
Jongaramruong, J. and N. Kongkam. 2007. Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from
a brown alga Dictyota sp. J. Asian Nat. Prod. Res. 9: 743–751.
Jung, M.E. and G.-Y.J. Im. 2008. Convergent total synthesis of the racemic HIF-1 inhibitor laurenditerpenol. Tetrahedron
Lett. 49: 4962–4964.
Karadag, A., B. Ozcelik and S. Saner. 2009. Review of methods to determine antioxidant capacities. Food Anal. Methods
2: 41–60.
Karran, E., M. Mercken and B. Strooper. 2011. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the
development of therapeutics. Nat. Rev. Drug. Discov. 10: 698–712.
Kazłowska, K., T. Hsu, C.-C. Hou, W.-C. Yang and G.-J Tsai. 2010. Anti-inflammatory properties of phenolic compounds and
crude extract from Porphyra dentata. J. Ethnopharmacol. 128: 123–130.
Khanavi, M., M. Nabavi, N. Sadati, M. Shams Ardekani, J. Sohrabipour, S.M. Nabavi, P. Ghaeli and S.N. Ostad. 2010.
Cytotoxic activity of some marine brown algae against cancer cell lines. Biol. Res. 43: 31–37.
Khanavi, M., R. Gheidarloo, N. Sadati, M.R. Ardekani, S.M. Nabavi, S. Tavajohi and S.N. Ostad. 2012. Cytotoxicity of
fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn. Mag. 8: 60–64.
Kim, K.-N., S.-J. Heo, W.-J. Yoon, S.-M. Kang, G. Ahn, T.-H. Yi and Y.-J. Jeon. 2010. Fucoxanthin inhibits the inflammatory
response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages.
Eur. J. Pharmacol. 649: 369–375.
Kim, M.K., J.W. Park, C.S. Park, S.J. Kim, K.H. Jeune, M.U. Chang and J. Acreman. 2007. Enhanced production of Scenedesmus
spp. (green microalgae) using a new medium containing fermented swine wastewater. Biores. Technol. 98: 2220–2228.
Kim, M.M., E. Mendis and S.K. Kim. 2008. Laurencia okamurai extract containing laurinterol induces apoptosis in melanoma
cells. J. Med. Food 11: 260–266.
Kladia, M., C. Vagias, G. Furnari, D. Morreau, C. Roussakis and V. Roussis. 2005. Cytotoxic cuparene sesquiterpenes from
Laurencia microcladia. Tetrahedron Lett. 46: 5723–5726.
Ko, S.-C., D. Kim and Y.-J. Jeon. 2012. Protective effect of a novel antioxidative peptide purified from a marine Chlorella
ellipsoidea protein against free radical-induced oxidative stress. Food Chem. Toxicol. 50: 2294–2302.
Genovese, G., L. Tedone, M. Hamann and M. Morabito. 2009. The mediterranean red alga Asparagopsis: A source of compounds
against Leishmania. Mar. Drugs 7: 361–366.
Govindan, M., S.A. Abbas, E.I. Schmitz, R.H. Lee, I.S. Papkoff and D.L. Slate. 1994. New cycloartanol sulfates from the alga
Tydemania expeditionis: inhibitor of the protein tyrosin kinase pp60. J. Nat. Prod. 57: 74–78.
Gross, H., D.E. Goeger, P. Hills, S.L. Mooberry, D.L. Ballantine, T.F. Murray, F.A. Valeriote and W.H. Gerwick. 2006.
Lophocladines, bioactive alkaloids from the red alga Lophocladia sp. J. Nat. Prod. 69: 640–644.
Guardia, S.D., R. Valls, V. Mesguiche, J.-M. Brunei and G. Gulioli. 1999. Enantioselective synthesis of (–)-bifuracadiol: a
natural antitumor marine product. Tetrahedron Lett. 40: 8359–8360.
Guedes, A.C., H.M. Amaro and F.X. Malcata. 2011. Microalgae as sources of high added-value compounds—a brief review
of recent work. Biotechnol. Prog. 27: 597–613.
Gulioli, G., A. Oratalo-Magne, M. Daoudi, H. Thomas Guyon, R. Vallis and L. Piovetti. 2004. Trihydroxylated linear diterpenes
from the brown alga Bifurcaria bifurcata. Phytochemistry 65: 2063–2069.
Güven, K.C., A. Percot and E. Sezik. 2010. Alkaloids in marine algae. Mar. Drugs 8: 269–284.
Haefner, B. 2003. Drugs from the deep: marine natural products as drug candidates. Drug Discov. Today 8: 536–544.
Hamann, M.T. and P.J. Scheuer. 1993. Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens
and the green alga Bryopsis sp. J. Am. Chem. Soc. 115: 5825–5826.
Henríquez, R., G. Faircloth and C. Cuevas. 2005. Ecteinascidin 743 (ET-743, Yondelis), aplidin and kahalalide F. In:
G.M. Cragg, D.G.I. Kingston and D.J. Newman (eds.). Anticancer Agents from Natural Products. Taylor and Francis,
Boca Raton, Florida.
Heo, S.-J. and Y.-J. Jeon. 2009. Evaluation of diphlorethohydroxycarmalol isolated from Ishige okamurae for radical scavenging
activity and its protective effect against H 2 O 2 -induced cell damage. Process Biochem. 44: 412–418.
Heo, S.-J., W.-J. Yoon, K.-N. Kim, G.-N. Ahn, S.-M. Kang, D.-H. Kang, A. Affan, C. Oh, W.-K. Jung and Y.-J. Jeon. 2010.
Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW
264.7 macrophages. Food Chem. Toxicol. 48: 2045–2051.
Higuera-Ciapara, I., L. Félix-Valenzuela and M. Goycoolea. 2006. Astaxanthin: a review of its chemistry and applications.
Crit. Rev. Food Sci. 46: 185–196.
Honer, W.G. 2003. Pathology of presynaptic proteins in Alzheimer’s disease: more than simple loss of terminals. Neurobiol.
Aging 24: 1047–1062.
Huang, H.L., S.L. Wu, H.F. Liao, C.M. Jiang, R.L. Huang, Y.Y. Chen, Y.C. Yang and Y.J. Chen. 2005. Induction of apoptosis
by three marine algae through generation of reactive oxygen species in human leukemic cell lines. J. Agric. Food.
Chem. 53: 1776–1781.
Ishitsuka, O.M., T. Kusumi and H. Kakisawa H. 1988. Antitumor xenicane and norxenicane lactones from the brown algae
Dictyota dichotoma. J. Org. Chem. 53: 5010–5013.
Jaswir, I. and H.A. Monsur. 2011. Anti-inflammatory compounds of macro algae origin: A review. J. Med. Plants Res. 5:
7146–7154.
Jimeno, J., G. Faircloth, J.M. Fernández Sousa-Faro, P. Scheuer and K. Rinehart. 2004. New marine derived anticancer
therapeutics—a journey from the sea to clinical trials. Mar. Drugs 2: 14–29.
Jongaramruong, J. and N. Kongkam. 2007. Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from
a brown alga Dictyota sp. J. Asian Nat. Prod. Res. 9: 743–751.
Jung, M.E. and G.-Y.J. Im. 2008. Convergent total synthesis of the racemic HIF-1 inhibitor laurenditerpenol. Tetrahedron
Lett. 49: 4962–4964.
Karadag, A., B. Ozcelik and S. Saner. 2009. Review of methods to determine antioxidant capacities. Food Anal. Methods
2: 41–60.
Karran, E., M. Mercken and B. Strooper. 2011. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the
development of therapeutics. Nat. Rev. Drug. Discov. 10: 698–712.
Kazłowska, K., T. Hsu, C.-C. Hou, W.-C. Yang and G.-J Tsai. 2010. Anti-inflammatory properties of phenolic compounds and
crude extract from Porphyra dentata. J. Ethnopharmacol. 128: 123–130.
Khanavi, M., M. Nabavi, N. Sadati, M. Shams Ardekani, J. Sohrabipour, S.M. Nabavi, P. Ghaeli and S.N. Ostad. 2010.
Cytotoxic activity of some marine brown algae against cancer cell lines. Biol. Res. 43: 31–37.
Khanavi, M., R. Gheidarloo, N. Sadati, M.R. Ardekani, S.M. Nabavi, S. Tavajohi and S.N. Ostad. 2012. Cytotoxicity of
fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn. Mag. 8: 60–64.
Kim, K.-N., S.-J. Heo, W.-J. Yoon, S.-M. Kang, G. Ahn, T.-H. Yi and Y.-J. Jeon. 2010. Fucoxanthin inhibits the inflammatory
response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages.
Eur. J. Pharmacol. 649: 369–375.
Kim, M.K., J.W. Park, C.S. Park, S.J. Kim, K.H. Jeune, M.U. Chang and J. Acreman. 2007. Enhanced production of Scenedesmus
spp. (green microalgae) using a new medium containing fermented swine wastewater. Biores. Technol. 98: 2220–2228.
Kim, M.M., E. Mendis and S.K. Kim. 2008. Laurencia okamurai extract containing laurinterol induces apoptosis in melanoma
cells. J. Med. Food 11: 260–266.
Kladia, M., C. Vagias, G. Furnari, D. Morreau, C. Roussakis and V. Roussis. 2005. Cytotoxic cuparene sesquiterpenes from
Laurencia microcladia. Tetrahedron Lett. 46: 5723–5726.
Ko, S.-C., D. Kim and Y.-J. Jeon. 2012. Protective effect of a novel antioxidative peptide purified from a marine Chlorella
ellipsoidea protein against free radical-induced oxidative stress. Food Chem. Toxicol. 50: 2294–2302.