Environmental Fluoride
165
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Ref: 4365 MING-HO YU Chap-010 Page: 165 149-170
FIGURE 10.9 Autoradiographs showing [214
C]thymidine incorporation in radicle of mung bean
seedling treated with (a) water or with (b) 1 mM NaF for 12 hours. (Black grains show the
developed silver deposited in the nuclei of dividing cells of the radicle, and are considered the
sites of [214
C]thymidine incorporation into DNA in the tissue.
Source: Narita, A. et al., Fluoride, 29, 72, 1996.
As noted in Chapter 6, superoxide dismutase (SOD) is an important
antioxidant enzyme. Field and laboratory studies have shown that SOD
activities in different plant tissues exposed to F were either enhanced or
lowered. For instance, mung bean seedlings exposed to 0.2 mM NaF showed
an enhanced SOD activity, whereas exposure to 1 mM NaF and above resulted
in depressed SOD activity.
30
10.7.2 IN ANIMALS AND HUMANS
F inhibits the metabolism of carbohydrates, lipids, and proteins. In animals
and humans, a large number of enzymes are depressed by F, including enolase,
165
[16:52 26/8/04 P:/CRC PRESS/4365 MING-HO.751 (1670)/4365-010.3d]
Ref: 4365 MING-HO YU Chap-010 Page: 165 149-170
FIGURE 10.9 Autoradiographs showing [214
C]thymidine incorporation in radicle of mung bean
seedling treated with (a) water or with (b) 1 mM NaF for 12 hours. (Black grains show the
developed silver deposited in the nuclei of dividing cells of the radicle, and are considered the
sites of [214
C]thymidine incorporation into DNA in the tissue.
Source: Narita, A. et al., Fluoride, 29, 72, 1996.
As noted in Chapter 6, superoxide dismutase (SOD) is an important
antioxidant enzyme. Field and laboratory studies have shown that SOD
activities in different plant tissues exposed to F were either enhanced or
lowered. For instance, mung bean seedlings exposed to 0.2 mM NaF showed
an enhanced SOD activity, whereas exposure to 1 mM NaF and above resulted
in depressed SOD activity.
30
10.7.2 IN ANIMALS AND HUMANS
F inhibits the metabolism of carbohydrates, lipids, and proteins. In animals
and humans, a large number of enzymes are depressed by F, including enolase,