3 Bio-microelectromechanical Systems (BioMEMS) in Bio-sensing …
73
Table 3.1
(continued)
BioMEMS platform
Main components
Fabrication strategy
Mechanisms of
operation
Detected analyte
Specifics
Ref
OLED hybrid
integrated polymer
microfluidic biosensor
• OLED
• PDMS
microfluidic chip
• Inlets and outlets
• Rinsing ports
Pre-PDMS was
prepared by curing
agent prior to casting
over metal
master-mold, which
was later cured in an
oven at 90 °C, and
then bound to a
second PDMS sheet.
Moreover, ITO was
lithographically
patterned and treated
by oxygen plasma
before being
subjected to a vacuum
chamber for organic
material evaporation
In sterilized PDMS
chip, fluids were
guided by suction
towards mixing
chamber. General
sandwich
immunoassay was
carried out to trap the
analyte and tag it. To
obtain a fluorescent
response, the OLED
was activated with a
9 V variable DC
voltage source, and
response was
measured through a
spectrometer
Donkey anti-sheep
IgG
A minimum
emission response
was detected at a
concentration 5
times lower than
that of original
sample (2
µg/mL)
If properly
sterilized with
water and
iso-propyl alcohol
(IPA), the device
can be used up to 3
times
Acharya et al.
(2015)
(continued)