72
L. Acosta-Soto and S. Hosseini
Table 3.1
(continued)
BioMEMS platform
Main components
Fabrication strategy
Mechanisms of
operation
Detected analyte
Specifics
Ref
• WFP
• TbCl
3
The channels and
corresponding
grading scale were
printed onto paper.
Later, TbCl
3 was
deposited on top of
the paper to be
absorbed
The tear samples were
deposited onto the
device, and after
pre-defined lapse of
time the device was
tested for fluorescent
signals for
quantification of
lactoferrin
concentration
Lactoferrin
An antibody-free
method for
detection of
lactoferrin in tear
fluid was
experimentally
validated
Sonobe
(2019)
• WFP
• Geometric radial
pattern
The pattern was
designed via
graphic-design
software, and later
was wax printed onto
WFP using a
heating/melting
mechanism
Sample was deposited
into center port and
traveled across the
platform by capillary
forces towards the
analytical zones
• Ag
• Hg
• Aminoglycans of
antibiotics
Though intended to
interact with only
one antibiotic, the
similarity between
different antibiotics
from this family
allows detection of
multiple analytes of
interest
Zhang et al.
(2015)
(continued)