34
M. A. Espinosa-Hernandez et al.
Table 2.1
(continued)
BioMEMS platform
Main components
Fabrication strategy Mechanisms of
operation
Detected analyte
Specifics
References
LAMP Integrated
rotary microfluidic
system
• Centrifugal
microfluidic platform
• Glass microbeads
solid phase matrix
base
Multiple
microfluidic layers
were created using a
CNC milling
machine. To
assemble the three
layers, a PSA film
was used after
cutting the
micropattern by a
plotter. All layers
were aligned and
bonded by a hot
press
This microdevice
incorporates the whole
procedure for nucleic
acid-based test,
including the
solid-phase nucleic
acid extraction, the
LAMP reaction, and
the lateral flow strip
based colorimetric
detection
• Salmonella
Typhimurium
• Salmonella
• Typhimurium
• Vibrio
parahaemolyticus
High performances
of the microdevice
provided great
potential as a
user-friendly POC
analyzer that can be
applicable to
resource limited
environments
Park et al.
(2016)
Smartphone
spectrometer
• Smartphone
• Grated CD
• Built-in LED
• CMOS camera
The grating tracks of
the CD were tilted
with respect to the
LED but normal to
the incident light so
the light may be
refracted from the
CD on the camera.
The flashlight was
emitted through a
pinhole in front of
the LED
A bi-enzymatic
cascade assay and
peptide-functionalized
AuNPs were used to
detect glucose and
troponin I respectively
• GLU
• Troponin I
This device allows
real-time
measurements with
LOD of approx.
50 ng mL-1. It
presented similar
results to
commercial devices
while offering a
compact
cost-effective tool
Wang et al.
(2016)
(continued)