7 Bio-microelectromechanical Systems (BioMEMS) …
155
Table 7.1
Recent BioMEMS platforms for biochemiluminescence detection: Type of the platform, main components, fabrication strategy, mechanism of
operation. The analyte of interest, and the advantages and disadvantages of each platform are presented in this table
BioMEMS
platform
Main components
Fabrication strategy Mechanisms of
operation
Detected
analyte
Specifics
References
Microfluidic chip • Micro mixer
• Detecting pool
• Waste liquid buffer
pool
• Optical fiber
interface
Through a
proprietary method
several layers of
microfluidic were
aligned and attached
to each other in
order to conduct the
assay
The reaction mixture
was inserted to the
device via the inlet. All
different layers of the
device were in
communication. After
the assay process was
followed the signal
readout took place
above the detection pool
Single blood
erythrocyte
The device
demonstrates a rapid
and highly sensitive
method
Microfluidic chip for
biological
chemiluminescence
detection and detection
method thereof (2012)
Cartridge-based
BL-CL
measurement
• Cartridge
• Measurement
apparatus
• Reaction vessel
Through a
proprietary method,
a cartridge was
equipped with an
inlet and an outlet
as well as a reaction
vessel
The dry reagents were
stored in different
concentrations inside
the cartridge. A solvent
was transferred through
the device dissolving
the dry samples thus
BL-CL reaction
Endotoxin
and
β-glucan
The device
demonstrated a low
chance of
contamination of
reagents. However, a
major challenge was
preventing the
deterioration of the
reagent containing
biological
compounds
Measuring method
(2013)
(continued)
155
Table 7.1
Recent BioMEMS platforms for biochemiluminescence detection: Type of the platform, main components, fabrication strategy, mechanism of
operation. The analyte of interest, and the advantages and disadvantages of each platform are presented in this table
BioMEMS
platform
Main components
Fabrication strategy Mechanisms of
operation
Detected
analyte
Specifics
References
Microfluidic chip • Micro mixer
• Detecting pool
• Waste liquid buffer
pool
• Optical fiber
interface
Through a
proprietary method
several layers of
microfluidic were
aligned and attached
to each other in
order to conduct the
assay
The reaction mixture
was inserted to the
device via the inlet. All
different layers of the
device were in
communication. After
the assay process was
followed the signal
readout took place
above the detection pool
Single blood
erythrocyte
The device
demonstrates a rapid
and highly sensitive
method
Microfluidic chip for
biological
chemiluminescence
detection and detection
method thereof (2012)
Cartridge-based
BL-CL
measurement
• Cartridge
• Measurement
apparatus
• Reaction vessel
Through a
proprietary method,
a cartridge was
equipped with an
inlet and an outlet
as well as a reaction
vessel
The dry reagents were
stored in different
concentrations inside
the cartridge. A solvent
was transferred through
the device dissolving
the dry samples thus
BL-CL reaction
Endotoxin
and
β-glucan
The device
demonstrated a low
chance of
contamination of
reagents. However, a
major challenge was
preventing the
deterioration of the
reagent containing
biological
compounds
Measuring method
(2013)
(continued)