6 Bio-microelectromechanical Systems (BioMEMS) …
125
Table 6.1
Recent BioMEMS platforms for chemiluminescence detection: Type of the platform, main components, fabrication strategy, mechanism of operation.
The analyte of interest, and the advantages and disadvantages of each platform are presented in this table
BioMEMS platform
Main components
Fabrication strategy
Mechanisms of operation Detected analyte
Specifics
References
μPAD DNA sensor
• Microfluidic
paper-based array
• C-dots@NPG
The fabrication of
μPADs
was done via
wax-screen-printing in an
array of 6 columns by 3
rows. The paper was
wax-screen-printed. The
wax was melted and
penetrated deeply into the
paper to create complete
hydrophobic barriers to
form the micro-zones.
NPG was prepared by
selective dissolution of
silver from silver/gold
alloy via etching. The
surface electrodes were
modified under DSC and
C-dots@NPG where used
as the amplification label
Under the presence of the
potassium permanganate,
a sandwich-type DNA
hybridization reaction
occurred
DNA
Due to its simple
protocol the device
required no additional
machinery for its
operation making it a
powerful potential POC
testing diagnosis tool
Wang et al. (2013)
(continued)
125
Table 6.1
Recent BioMEMS platforms for chemiluminescence detection: Type of the platform, main components, fabrication strategy, mechanism of operation.
The analyte of interest, and the advantages and disadvantages of each platform are presented in this table
BioMEMS platform
Main components
Fabrication strategy
Mechanisms of operation Detected analyte
Specifics
References
μPAD DNA sensor
• Microfluidic
paper-based array
• C-dots@NPG
The fabrication of
μPADs
was done via
wax-screen-printing in an
array of 6 columns by 3
rows. The paper was
wax-screen-printed. The
wax was melted and
penetrated deeply into the
paper to create complete
hydrophobic barriers to
form the micro-zones.
NPG was prepared by
selective dissolution of
silver from silver/gold
alloy via etching. The
surface electrodes were
modified under DSC and
C-dots@NPG where used
as the amplification label
Under the presence of the
potassium permanganate,
a sandwich-type DNA
hybridization reaction
occurred
DNA
Due to its simple
protocol the device
required no additional
machinery for its
operation making it a
powerful potential POC
testing diagnosis tool
Wang et al. (2013)
(continued)