Nanomaterials for Medical Imaging …
387
57. Heiligtag FJ, Niederberger M (2013) The fascinating world of nanoparticle research. Mater
Today 16(7–8):262–271. https://doi.org/10.1016/j.mattod.2013.07.004
58. Banstola A, Emami F, Jeong J-H, Yook S (2018) Current applications of gold nanoparticles
for medical imaging and as treatment agents for managing pancreatic cancer. Macromol Res
26(11):955–964. https://doi.org/10.1007/s13233-018-6139-4
59. Cole LE, Ross RD, Tilley JM, Vargo-Gogola T, Roeder RK (2015) Gold nanoparticles as
contrast agents in x-ray imaging and computed tomography. Nanomedicine (Lond) 10(2):321–
341. https://doi.org/10.2217/nnm.14.171
60. Xi D, Dong S, Meng X, Lu Q, Meng L, Ye J (2012) Gold nanoparticles as computerized
tomography (CT) contrast agents. RSC Adv 2(33):12515. https://doi.org/10.1039/c2ra21263c
61. Ide JM, Lancelot E, Pines E, Corot C (2004) Prophylaxis of iodinated contrast media-induced
nephropathy: a pharmacological point of view. Invest Radiol 39(3):155–170. https://doi.org/
10.1097/01.rli.0000101483.60710.2c
62. Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM (2006) Gold nanoparticles: a new X-ray
contrast agent. The Br J Radiol 79(939):248–253. https://doi.org/10.1259/bjr/13169882
63. Ross RD, Cole LE, Tilley JMR, Roeder RK (2014) Effects of functionalized gold nanoparticle
size on X-ray attenuation and substrate binding affinity. Chem Mater 26(2):1187–1194. https://
doi.org/10.1021/cm4035616
64. Kattumuri V, Katti K, Bhaskaran S, Boote EJ, Casteel SW, Fent GM, Robertson DJ, Chandrasekhar M, Kannan R, Katti KV (2007) Gum arabic as a phytochemical construct for
the stabilization of gold nanoparticles: in vivo pharmacokinetics and X-ray-contrast-imaging
studies. Small 3(2):333–341. https://doi.org/10.1002/smll.200600427
65. Kim D, Park S, Lee JH, Jeong YY, Jon S (2007) Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc
129(24):7661–7665. https://doi.org/10.1021/ja071471p
66. Peng C, Zheng L, Chen Q, Shen M, Guo R, Wang H, Cao X, Zhang G, Shi X (2012) PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging
by computed tomography. Biomaterials 33(4):1107–1119. https://doi.org/10.1016/j.biomat
erials.2011.10.052
67. Kojima C, Umeda Y, Ogawa M, Harada A, Magata Y, Kono K (2010) X-ray computed
tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. Nanotechnology 21(24):245104. https://doi.org/10.1088/0957-4484/21/24/
245104
68. Zhang XD, Wu D, Shen X, Liu PX, Yang N, Zhao B, Zhang H, Sun YM, Zhang LA, Fan
FY (2011) Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomed
6:2071–2081. https://doi.org/10.2147/IJN.S21657
69. Zhang XD, Wu HY, Wu D, Wang YY, Chang JH, Zhai ZB, Meng AM, Liu PX, Zhang LA,
Fan FY (2010) Toxicologic effects of gold nanoparticles in vivo by different administration
routes. Int J Nanomed 5:771–781. https://doi.org/10.2147/IJN.S8428
70. Zhang XD, Wu D, Shen X, Chen J, Sun YM, Liu PX, Liang XJ (2012) Size-dependent
radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials
33(27):6408–6419. https://doi.org/10.1016/j.biomaterials.2012.05.047
71. Srinoi P, Chen Y-T, Vittur V, Marquez M, Lee T (2018) Bimetallic nanoparticles: enhanced
magnetic and optical properties for emerging biological applications. Appl Sci 8(7):1106.
https://doi.org/10.3390/app8071106
72. Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES,
Maidment AD, Cormode DP (2016) Gold silver alloy nanoparticles (GSAN): an imaging
probe for breast cancer screening with dual-energy mammography or computed tomography.
Nanoscale 8(28):13740–13754. https://doi.org/10.1039/c6nr02618d
73. Wang H, Zheng L, Guo R, Peng C, Shen M, Shi X, Zhang G (2012) Dendrimer-entrapped
gold nanoparticles as potential CT contrast agents for blood pool imaging. Nanoscale Res
Lett 7:190. https://doi.org/10.1186/1556-276X-7-190
387
57. Heiligtag FJ, Niederberger M (2013) The fascinating world of nanoparticle research. Mater
Today 16(7–8):262–271. https://doi.org/10.1016/j.mattod.2013.07.004
58. Banstola A, Emami F, Jeong J-H, Yook S (2018) Current applications of gold nanoparticles
for medical imaging and as treatment agents for managing pancreatic cancer. Macromol Res
26(11):955–964. https://doi.org/10.1007/s13233-018-6139-4
59. Cole LE, Ross RD, Tilley JM, Vargo-Gogola T, Roeder RK (2015) Gold nanoparticles as
contrast agents in x-ray imaging and computed tomography. Nanomedicine (Lond) 10(2):321–
341. https://doi.org/10.2217/nnm.14.171
60. Xi D, Dong S, Meng X, Lu Q, Meng L, Ye J (2012) Gold nanoparticles as computerized
tomography (CT) contrast agents. RSC Adv 2(33):12515. https://doi.org/10.1039/c2ra21263c
61. Ide JM, Lancelot E, Pines E, Corot C (2004) Prophylaxis of iodinated contrast media-induced
nephropathy: a pharmacological point of view. Invest Radiol 39(3):155–170. https://doi.org/
10.1097/01.rli.0000101483.60710.2c
62. Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM (2006) Gold nanoparticles: a new X-ray
contrast agent. The Br J Radiol 79(939):248–253. https://doi.org/10.1259/bjr/13169882
63. Ross RD, Cole LE, Tilley JMR, Roeder RK (2014) Effects of functionalized gold nanoparticle
size on X-ray attenuation and substrate binding affinity. Chem Mater 26(2):1187–1194. https://
doi.org/10.1021/cm4035616
64. Kattumuri V, Katti K, Bhaskaran S, Boote EJ, Casteel SW, Fent GM, Robertson DJ, Chandrasekhar M, Kannan R, Katti KV (2007) Gum arabic as a phytochemical construct for
the stabilization of gold nanoparticles: in vivo pharmacokinetics and X-ray-contrast-imaging
studies. Small 3(2):333–341. https://doi.org/10.1002/smll.200600427
65. Kim D, Park S, Lee JH, Jeong YY, Jon S (2007) Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc
129(24):7661–7665. https://doi.org/10.1021/ja071471p
66. Peng C, Zheng L, Chen Q, Shen M, Guo R, Wang H, Cao X, Zhang G, Shi X (2012) PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging
by computed tomography. Biomaterials 33(4):1107–1119. https://doi.org/10.1016/j.biomat
erials.2011.10.052
67. Kojima C, Umeda Y, Ogawa M, Harada A, Magata Y, Kono K (2010) X-ray computed
tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. Nanotechnology 21(24):245104. https://doi.org/10.1088/0957-4484/21/24/
245104
68. Zhang XD, Wu D, Shen X, Liu PX, Yang N, Zhao B, Zhang H, Sun YM, Zhang LA, Fan
FY (2011) Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomed
6:2071–2081. https://doi.org/10.2147/IJN.S21657
69. Zhang XD, Wu HY, Wu D, Wang YY, Chang JH, Zhai ZB, Meng AM, Liu PX, Zhang LA,
Fan FY (2010) Toxicologic effects of gold nanoparticles in vivo by different administration
routes. Int J Nanomed 5:771–781. https://doi.org/10.2147/IJN.S8428
70. Zhang XD, Wu D, Shen X, Chen J, Sun YM, Liu PX, Liang XJ (2012) Size-dependent
radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials
33(27):6408–6419. https://doi.org/10.1016/j.biomaterials.2012.05.047
71. Srinoi P, Chen Y-T, Vittur V, Marquez M, Lee T (2018) Bimetallic nanoparticles: enhanced
magnetic and optical properties for emerging biological applications. Appl Sci 8(7):1106.
https://doi.org/10.3390/app8071106
72. Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES,
Maidment AD, Cormode DP (2016) Gold silver alloy nanoparticles (GSAN): an imaging
probe for breast cancer screening with dual-energy mammography or computed tomography.
Nanoscale 8(28):13740–13754. https://doi.org/10.1039/c6nr02618d
73. Wang H, Zheng L, Guo R, Peng C, Shen M, Shi X, Zhang G (2012) Dendrimer-entrapped
gold nanoparticles as potential CT contrast agents for blood pool imaging. Nanoscale Res
Lett 7:190. https://doi.org/10.1186/1556-276X-7-190