Quorum Sensing Inhibitors as an Alternate …
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Table 1
(continued)
Pathogens
Signal molecules
QS regulated phenotypic
factors
Host organism
Diseases
Reported QSI
compounds
V. anguillarum
3-oxo-C10-HSL and
C6-HSL
Extracellular protease,
Pigment production,
Haemolysin and Biofilm
formation
Fish
Haemorrhagic
septicaemia
Furanone C-30,
Cinnamaldehyde and its
derivatives
V. alginolyticus
AI-2
Total extracellular
protease, Haemolysin,
Motility and Biofilm
formation
Fish, Abalone and
Mussel
Shell disease,
Superficial wound
Infections, Septicemia,
haemorrhaging, dark
skin, and ulcers on the
skin surface, mortality
Turmeric extract,
Palmitic acid and
Secondary metabolites
from Bacillus
spp.
V. parahaemolyticus
LuxO (represses SmcR)
OpaR (LuxR
homologue)
Cytotoxins and RtxA1
Shrimp and humans
Early mortality
syndrome in shrimp,
Mild gastroenteritis to
severe debilitating
dysentery, eye and ear
infections, wound
infections of the
extremitiesin human
Curcumin, Phenolic and
Flavonoids,
Cinnamaldehyde and its
derivatives, Turmeric
extract, Palmitic acid
V. vulnificus
AI-2 (SmcR -LuxR
homologue)
Metalloprotease,
Virulence enzymes and
Biofilm formation
Fish and Humans
Primary septicemias,
Wound infections in
fish, and
Gastrointestinal
Illnessesin human
Curcumin, Phenolic and
Flavonoids,
Cinnamaldehyde and its
derivatives, Turmeric
extract