tolerance in Aspergillus nidulans. Eukaryot Cell
10:1504–1515
Gao F, Hao Z, Sun X, Qin L, Zhao T, Liu W, Luo H, Yao
B, Su X (2018) A versatile system for fast screening
and isolation of Trichoderma reesei cellulase
hyperproducers
based
on
DsRed
and
fluorescence-assisted cell sorting. Biotechnol Biofuels 11:261
Gardner BM, Pincus D, Gotthardt K, Gallagher CM,
Walter P (2013) Endoplasmic reticulum stress
sensing in the unfolded protein response. Cold
Spring Harb Perspect Biol 5:a013169
Gardner BM, Walter P (2011) Unfolded proteins are
Ire1-activating ligands that directly induce the
unfolded protein response. Science 333:1891–
1894
Garrido-Bazan V, Jaimes-Arroyo R, Sanchez O, LaraRojas F, Aguirre J (2018) SakA and MpkC stress
MAPKs show opposite and common functions
during stress responses and development in Aspergillus nidulans. Front Microbiol 9:2518
Gauss R, Kanehara K, Carvalho P, Ng DT, Aebi M
(2011) A complex of Pdi1p and the mannosidase
Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum. Mol Cell
42:782–793
Gillece P, Luz JM, Lennarz WJ, de La Cruz FJ, Romisch
K (1999) Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for
degradation requires interaction with protein
disulfide isomerase. J Cell Biol 147:1443–1456
Glawischnig E (2007) Camalexin. Phytochemistry
68:401–406
Glazier VE, Kaur JN, Brown NT, Rivera AA, Panepinto
JC (2015) Puf4 regulates both splicing and decay of
HXL1 mRNA encoding the unfolded protein
response transcription factor in Cryptococcus neoformans. Eukaryot Cell 14:385–395
Glazier VE, Panepinto JC (2014) The ER stress response
and host temperature adaptation in the human
fungal pathogen Cryptococcus neoformans. Virulence 5:351–356
Goh J, Jeon J, Lee YH (2017) ER retention receptor,
MoERR1 is required for fungal development and
pathogenicity in the rice blast fungus, Magnaporthe oryzae. Sci Rep 7:1259
Gonzalez-Rubio G, Fernandez-Acero T, Martin H,
Molina M (2019) Mitogen-activated protein kinase
phosphatases (MKPs) in fungal signaling: conservation, function, and regulation. Int J Mol Sci 20
(7):1709
Grahl N, Shepardson KM, Chung D, Cramer RA (2012)
Hypoxia and fungal pathogenesis: to air or not to
air? Eukaryot Cell 11:560–570
Grubb S, Guo L, Fisher EA, Brodsky JL (2012) Protein
disulfide isomerases contribute differentially to
the endoplasmic reticulum-associated degradation
of apolipoprotein B and other substrates. Mol Biol
Cell 23:520–532
Guillemette T, Calmes B, Simoneau P (2014) Impact of
the UPR on the virulence of the plant fungal pathogen A. brassicicola. Virulence 5:357–364
Guillemette T, van Peij N, Goosen T, Lanthaler K, Robson GD, van den Hondel CA, Stam H, Archer DB
(2007) Genomic analysis of the secretion stress
response in the enzyme-producing cell factory
Aspergillus niger. BMC Genomics 8:158
Hampel M, Jakobi M, Schmitz L, Meyer U, Finkernagel
F, Doehlemann G, Heimel K (2016) Unfolded protein response (UPR) regulator Cib1 controls
expression of genes encoding secreted virulence
factors in Ustilago maydis. PLoS One 11:e0153861
Hardwick KG, Lewis MJ, Semenza J, Dean N, Pelham
HR (1990) ERD1, a yeast gene required for the
retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi
apparatus. EMBO J 9:623–630
Havel VE, Wool NK, Ayad D, Downey KM, Wilson CF,
Larsen P, Djordjevic JT, Panepinto JC (2011) Ccr4
promotes resolution of the endoplasmic reticulum
stress response during host temperature adaptation in Cryptococcus neoformans. Eukaryot Cell
10:895–901
Heimel K (2015) Unfolded protein response in filamentous fungi-implications in biotechnology. Appl
Microbiol Biotechnol 99:121–132
Heimel K, Freitag J, Hampel M, Ast J, Bo ¨lker M, Ka ¨mper J (2013) Crosstalk between the unfolded protein response and pathways that regulate
pathogenic development in Ustilago maydis.
Plant Cell 25:4262–4277
Heimel K, Scherer M, Schuler D, Ka ¨mper J (2010a) The
Ustilago maydis Clp1 protein orchestrates pheromone and b-dependent signaling pathways to
coordinate the cell cycle and pathogenic development. Plant Cell 22:2908–2922
Heimel K, Scherer M, Vranes M, Wahl R, Pothiratana C,
Schuler D, Vincon V, Finkernagel F, Flor-Parra I,
Ka ¨mper J (2010b) The transcription factor Rbf1 is
the master regulator for b-mating type controlled
pathogenic development in Ustilago maydis. PLoS
Pathog 6:e1001035
Herzog B, Popova B, Jakobshagen A, Shahpasandzadeh
H, Braus GH (2013) Mutual crosstalk between the
regulators Hac1 of the unfolded protein response
and Gcn4 of the general amino acid control of
Saccharomyces cerevisiae. Eukaryot Cell
Hinnebusch AG (1994) The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress.
Semin Cell Biol 5:417–426
Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman
JS (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol
186:323–331
Hooks KB, Griffiths-Jones S (2011) Conserved RNA
structures in the non-canonical Hac1/Xbp1 intron.
RNA Biol 8:552–556
3 Genetics of the Unfolded Protein Response in Fungi
71
10:1504–1515
Gao F, Hao Z, Sun X, Qin L, Zhao T, Liu W, Luo H, Yao
B, Su X (2018) A versatile system for fast screening
and isolation of Trichoderma reesei cellulase
hyperproducers
based
on
DsRed
and
fluorescence-assisted cell sorting. Biotechnol Biofuels 11:261
Gardner BM, Pincus D, Gotthardt K, Gallagher CM,
Walter P (2013) Endoplasmic reticulum stress
sensing in the unfolded protein response. Cold
Spring Harb Perspect Biol 5:a013169
Gardner BM, Walter P (2011) Unfolded proteins are
Ire1-activating ligands that directly induce the
unfolded protein response. Science 333:1891–
1894
Garrido-Bazan V, Jaimes-Arroyo R, Sanchez O, LaraRojas F, Aguirre J (2018) SakA and MpkC stress
MAPKs show opposite and common functions
during stress responses and development in Aspergillus nidulans. Front Microbiol 9:2518
Gauss R, Kanehara K, Carvalho P, Ng DT, Aebi M
(2011) A complex of Pdi1p and the mannosidase
Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum. Mol Cell
42:782–793
Gillece P, Luz JM, Lennarz WJ, de La Cruz FJ, Romisch
K (1999) Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for
degradation requires interaction with protein
disulfide isomerase. J Cell Biol 147:1443–1456
Glawischnig E (2007) Camalexin. Phytochemistry
68:401–406
Glazier VE, Kaur JN, Brown NT, Rivera AA, Panepinto
JC (2015) Puf4 regulates both splicing and decay of
HXL1 mRNA encoding the unfolded protein
response transcription factor in Cryptococcus neoformans. Eukaryot Cell 14:385–395
Glazier VE, Panepinto JC (2014) The ER stress response
and host temperature adaptation in the human
fungal pathogen Cryptococcus neoformans. Virulence 5:351–356
Goh J, Jeon J, Lee YH (2017) ER retention receptor,
MoERR1 is required for fungal development and
pathogenicity in the rice blast fungus, Magnaporthe oryzae. Sci Rep 7:1259
Gonzalez-Rubio G, Fernandez-Acero T, Martin H,
Molina M (2019) Mitogen-activated protein kinase
phosphatases (MKPs) in fungal signaling: conservation, function, and regulation. Int J Mol Sci 20
(7):1709
Grahl N, Shepardson KM, Chung D, Cramer RA (2012)
Hypoxia and fungal pathogenesis: to air or not to
air? Eukaryot Cell 11:560–570
Grubb S, Guo L, Fisher EA, Brodsky JL (2012) Protein
disulfide isomerases contribute differentially to
the endoplasmic reticulum-associated degradation
of apolipoprotein B and other substrates. Mol Biol
Cell 23:520–532
Guillemette T, Calmes B, Simoneau P (2014) Impact of
the UPR on the virulence of the plant fungal pathogen A. brassicicola. Virulence 5:357–364
Guillemette T, van Peij N, Goosen T, Lanthaler K, Robson GD, van den Hondel CA, Stam H, Archer DB
(2007) Genomic analysis of the secretion stress
response in the enzyme-producing cell factory
Aspergillus niger. BMC Genomics 8:158
Hampel M, Jakobi M, Schmitz L, Meyer U, Finkernagel
F, Doehlemann G, Heimel K (2016) Unfolded protein response (UPR) regulator Cib1 controls
expression of genes encoding secreted virulence
factors in Ustilago maydis. PLoS One 11:e0153861
Hardwick KG, Lewis MJ, Semenza J, Dean N, Pelham
HR (1990) ERD1, a yeast gene required for the
retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi
apparatus. EMBO J 9:623–630
Havel VE, Wool NK, Ayad D, Downey KM, Wilson CF,
Larsen P, Djordjevic JT, Panepinto JC (2011) Ccr4
promotes resolution of the endoplasmic reticulum
stress response during host temperature adaptation in Cryptococcus neoformans. Eukaryot Cell
10:895–901
Heimel K (2015) Unfolded protein response in filamentous fungi-implications in biotechnology. Appl
Microbiol Biotechnol 99:121–132
Heimel K, Freitag J, Hampel M, Ast J, Bo ¨lker M, Ka ¨mper J (2013) Crosstalk between the unfolded protein response and pathways that regulate
pathogenic development in Ustilago maydis.
Plant Cell 25:4262–4277
Heimel K, Scherer M, Schuler D, Ka ¨mper J (2010a) The
Ustilago maydis Clp1 protein orchestrates pheromone and b-dependent signaling pathways to
coordinate the cell cycle and pathogenic development. Plant Cell 22:2908–2922
Heimel K, Scherer M, Vranes M, Wahl R, Pothiratana C,
Schuler D, Vincon V, Finkernagel F, Flor-Parra I,
Ka ¨mper J (2010b) The transcription factor Rbf1 is
the master regulator for b-mating type controlled
pathogenic development in Ustilago maydis. PLoS
Pathog 6:e1001035
Herzog B, Popova B, Jakobshagen A, Shahpasandzadeh
H, Braus GH (2013) Mutual crosstalk between the
regulators Hac1 of the unfolded protein response
and Gcn4 of the general amino acid control of
Saccharomyces cerevisiae. Eukaryot Cell
Hinnebusch AG (1994) The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress.
Semin Cell Biol 5:417–426
Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman
JS (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol
186:323–331
Hooks KB, Griffiths-Jones S (2011) Conserved RNA
structures in the non-canonical Hac1/Xbp1 intron.
RNA Biol 8:552–556
3 Genetics of the Unfolded Protein Response in Fungi
71