Cheon SA, Jung KW, Bahn YS, Kang HA (2014) The
unfolded protein response (UPR) pathway in
Cryptococcus. Virulence 5:341–350
Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS,
Kang HA (2011) Unique evolution of the UPR
pathway with a novel bZIP transcription factor,
Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 7:e1002177
Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS,
Carr SA, Deshaies RJ (2001) Negative regulation of
Gcn4 and Msn2 transcription factors by Srb10
cyclin-dependent kinase. Genes Dev 15:1078–1092
Cho Y (2015) How the necrotrophic fungus Alternaria
brassicicola kills plant cells remains an enigma.
Eukaryot Cell 14:335–344
Chun CD, Liu OW, Madhani HD (2007) A link between
virulence and homeostatic responses to hypoxia
during infection by the human fungal pathogen
Cryptococcus neoformans. PLoS Pathog 3:e22
Chung D, Barker BM, Carey CC, Merriman B, Werner
ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas
H, Mitchell AP, Cramer RA (2014) ChIP-seq and
in vivo transcriptome analyses of the Aspergillus
fumigatus SREBP SrbA reveals a new regulator of
the fungal hypoxia response and virulence. PLoS
Pathog 10:e1004487
Cohen N, Breker M, Bakunts A, Pesek K, Chas A,
Argemi J, Orsi A, Gal L, Chuartzman S, Wigelman
Y, Jonas F, Walter P, Ernst R, Aragon T, van Anken
E, Schuldiner M (2017) Iron affects Ire1 clustering
propensity and the amplitude of endoplasmic
reticulum stress signaling. J Cell Sci 130:3222–3233
Colabardini AC, De Castro PA, De Gouvea PF, Savoldi
M, Malavazi I, Goldman MH, Goldman GH (2010)
Involvement of the Aspergillus nidulans protein
kinase C with farnesol tolerance is related to the
unfolded protein response. Mol Microbiol
78:1259–1279
Conesa A, Jeenes D, Archer DB, van den Hondel CA,
Punt PJ (2002) Calnexin overexpression increases
manganese peroxidase production in Aspergillus
niger. Appl Environ Microbiol 68:846–851
Dean R, Van Kan JA, Pretorius ZA, Hammond-Kosack
KE, Di Pietro A, Spanu PD, Rudd JJ, Dickman M,
Kahmann R, Ellis J, Foster GD (2012) The top 10
fungal pathogens in molecular plant pathology.
Mol Plant Pathol 13:414–430
Derkx PM, Madrid SM (2001) The foldase CYPB is a
component of the secretory pathway of Aspergillus
niger and contains the endoplasmic reticulum
retention signal HEEL. Mol Genet Genomics
MGG 266:537–545
Di Stasio M, Brefort T, Mendoza-Mendoza A, Munch K,
Kahmann R (2009) The dual specificity phosphatase Rok1 negatively regulates mating and pathogenicity in Ustilago maydis. Mol Microbiol
73:73–88
Dichtl K, Helmschrott C, Dirr F, Wagener J (2012)
Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional
characterization of cell wall stress sensors and
relevant rho GTPases. Mol Microbiol 83:506–519
Dudgeon DD, Zhang N, Ositelu OO, Kim H, Cunningham KW (2008) Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90
and inhibited by calcineurin and Cmk2 in
response to endoplasmic reticulum stresses.
Eukaryot Cell 7:2037–2051
Escobar-Nino A, Lineiro E, Amil F, Carrasco R, Chiva
C, Fuentes C, Blanco-Ulate B, Cantoral Fernandez
JM, Sabido E, Fernandez-Acero FJ (2019) Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by
phosphorylation. Sci Rep 9:9860
Fan F, Ma G, Li J, Liu Q, Benz JP, Tian C, Ma Y (2015)
Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa. Biotechnol Biofuels 8:66
Fang W, Latge JP (2018) Microbe profile: Aspergillus
fumigatus: a saprotrophic and opportunistic fungal pathogen. Microbiology 164:1009–1011
Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L,
Grahl N, Powers-Fletcher MV, Zhang M, Fuller
KK, Nierman WC, Lu LJ, Latge JP, Woollett L,
Newman SL, Cramer RA Jr, Rhodes JC, Askew DS
(2011) HacA-independent functions of the ER
stress sensor IreA synergize with the canonical
UPR to influence virulence traits in Aspergillus
fumigatus. PLoS Pathog 7:e1002330
Fidel PL Jr, Vazquez JA, Sobel JD (1999) Candida glabrata: review of epidemiology, pathogenesis, and
clinical disease with comparison to C. albicans.
Clin Microbiol Rev 12:80–96
Fleissner A, Herzog S (2016) Signal exchange and integration during self-fusion in filamentous fungi.
Semin Cell Dev Biol 57:76–83
Flor-Parra I, Castillo-Lluva S, Perez-Martin J (2007)
Polar growth in the infectious hyphae of the phytopathogen Ustilago maydis depends on a
virulence-specific cyclin. Plant Cell 19:3280–3296
Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad
H, Walter P, Derisi JL (2012) Basic leucine zipper
transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Proc Natl Acad Sci U S A 109:E3084–E3093
Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B (2004) Consensus
analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite
topology of catalytic domains compared with presenilins. J Biol Chem 279:50790–50798
Futagami T, Nakao S, Kido Y, Oka T, Kajiwara Y,
Takashita H, Omori T, Furukawa K, Goto M
(2011) Putative stress sensors WscA and WscB
are involved in hypo-osmotic and acidic pH stress
70
R. Harting and K. Heimel
unfolded protein response (UPR) pathway in
Cryptococcus. Virulence 5:341–350
Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS,
Kang HA (2011) Unique evolution of the UPR
pathway with a novel bZIP transcription factor,
Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog 7:e1002177
Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS,
Carr SA, Deshaies RJ (2001) Negative regulation of
Gcn4 and Msn2 transcription factors by Srb10
cyclin-dependent kinase. Genes Dev 15:1078–1092
Cho Y (2015) How the necrotrophic fungus Alternaria
brassicicola kills plant cells remains an enigma.
Eukaryot Cell 14:335–344
Chun CD, Liu OW, Madhani HD (2007) A link between
virulence and homeostatic responses to hypoxia
during infection by the human fungal pathogen
Cryptococcus neoformans. PLoS Pathog 3:e22
Chung D, Barker BM, Carey CC, Merriman B, Werner
ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas
H, Mitchell AP, Cramer RA (2014) ChIP-seq and
in vivo transcriptome analyses of the Aspergillus
fumigatus SREBP SrbA reveals a new regulator of
the fungal hypoxia response and virulence. PLoS
Pathog 10:e1004487
Cohen N, Breker M, Bakunts A, Pesek K, Chas A,
Argemi J, Orsi A, Gal L, Chuartzman S, Wigelman
Y, Jonas F, Walter P, Ernst R, Aragon T, van Anken
E, Schuldiner M (2017) Iron affects Ire1 clustering
propensity and the amplitude of endoplasmic
reticulum stress signaling. J Cell Sci 130:3222–3233
Colabardini AC, De Castro PA, De Gouvea PF, Savoldi
M, Malavazi I, Goldman MH, Goldman GH (2010)
Involvement of the Aspergillus nidulans protein
kinase C with farnesol tolerance is related to the
unfolded protein response. Mol Microbiol
78:1259–1279
Conesa A, Jeenes D, Archer DB, van den Hondel CA,
Punt PJ (2002) Calnexin overexpression increases
manganese peroxidase production in Aspergillus
niger. Appl Environ Microbiol 68:846–851
Dean R, Van Kan JA, Pretorius ZA, Hammond-Kosack
KE, Di Pietro A, Spanu PD, Rudd JJ, Dickman M,
Kahmann R, Ellis J, Foster GD (2012) The top 10
fungal pathogens in molecular plant pathology.
Mol Plant Pathol 13:414–430
Derkx PM, Madrid SM (2001) The foldase CYPB is a
component of the secretory pathway of Aspergillus
niger and contains the endoplasmic reticulum
retention signal HEEL. Mol Genet Genomics
MGG 266:537–545
Di Stasio M, Brefort T, Mendoza-Mendoza A, Munch K,
Kahmann R (2009) The dual specificity phosphatase Rok1 negatively regulates mating and pathogenicity in Ustilago maydis. Mol Microbiol
73:73–88
Dichtl K, Helmschrott C, Dirr F, Wagener J (2012)
Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional
characterization of cell wall stress sensors and
relevant rho GTPases. Mol Microbiol 83:506–519
Dudgeon DD, Zhang N, Ositelu OO, Kim H, Cunningham KW (2008) Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90
and inhibited by calcineurin and Cmk2 in
response to endoplasmic reticulum stresses.
Eukaryot Cell 7:2037–2051
Escobar-Nino A, Lineiro E, Amil F, Carrasco R, Chiva
C, Fuentes C, Blanco-Ulate B, Cantoral Fernandez
JM, Sabido E, Fernandez-Acero FJ (2019) Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by
phosphorylation. Sci Rep 9:9860
Fan F, Ma G, Li J, Liu Q, Benz JP, Tian C, Ma Y (2015)
Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa. Biotechnol Biofuels 8:66
Fang W, Latge JP (2018) Microbe profile: Aspergillus
fumigatus: a saprotrophic and opportunistic fungal pathogen. Microbiology 164:1009–1011
Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L,
Grahl N, Powers-Fletcher MV, Zhang M, Fuller
KK, Nierman WC, Lu LJ, Latge JP, Woollett L,
Newman SL, Cramer RA Jr, Rhodes JC, Askew DS
(2011) HacA-independent functions of the ER
stress sensor IreA synergize with the canonical
UPR to influence virulence traits in Aspergillus
fumigatus. PLoS Pathog 7:e1002330
Fidel PL Jr, Vazquez JA, Sobel JD (1999) Candida glabrata: review of epidemiology, pathogenesis, and
clinical disease with comparison to C. albicans.
Clin Microbiol Rev 12:80–96
Fleissner A, Herzog S (2016) Signal exchange and integration during self-fusion in filamentous fungi.
Semin Cell Dev Biol 57:76–83
Flor-Parra I, Castillo-Lluva S, Perez-Martin J (2007)
Polar growth in the infectious hyphae of the phytopathogen Ustilago maydis depends on a
virulence-specific cyclin. Plant Cell 19:3280–3296
Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad
H, Walter P, Derisi JL (2012) Basic leucine zipper
transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Proc Natl Acad Sci U S A 109:E3084–E3093
Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B (2004) Consensus
analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite
topology of catalytic domains compared with presenilins. J Biol Chem 279:50790–50798
Futagami T, Nakao S, Kido Y, Oka T, Kajiwara Y,
Takashita H, Omori T, Furukawa K, Goto M
(2011) Putative stress sensors WscA and WscB
are involved in hypo-osmotic and acidic pH stress
70
R. Harting and K. Heimel