Promoter exchange, 270
Promoters, 238, 273, 330–332, 354, 355
constitutive, 238
identification, 240–241
inducible, 238
natural, 238
synthetic, 241
Pro-sequence, 245
Protease deficient strains, 249
Proteases, 249, 406
Protein
misfolded, 50
Protein degradation, 190, 191, 193–196
Protein glycosylation, 246
Protein synthesis
building blocks, 248
Protein tags and linkers, 242–243
Protein therapeutics, 328
Proteolytic sites, 243
Proteomics, 284
Proximal LRE (pLRE), 85
Pseurotin, 274, 278
Psilocybin, 276
Purification tags, 243
Pyridine coenzymes, 376
Pyruvate (PYR), 340–346
Q
Quelling, 109
R
Race tube, 78, 94
Rapid amplification of cDNA ends (RACE), 251
Recalcitrant substrate, 375
Recombinant protein, 328, 330–332
Regulated Ire1-dependent decay (RIDD), 53
Remediation, 388–391
Repeat, 209
Repressed under secretion stress (RESS), 67
Resistance mechanism, 250
Resistant structure, 416
Rhizomorph, 379
Ribosomal genes (rDNA), 110
Rice, 152, 153
RIP homotypic interaction motif, 134
RNA interference, 13
RNA interference machinery (RNAi), 149
RNase, 50
S
Salt demand, 402
Sanger sequencing, 208
Saprophytes, 401
Sapwood, 369, 386–388, 391
SCF complex, 189, 191, 192
Sea water, 407
Secondary metabolites, 174–179, 181–183, 186–
188, 191, 192, 194–196, 212–213, 267, 320,
322, 324–328, 333, 404–405
biosynthetic gene cluster, 177, 186
biosynthetic pathways, 251
compartmentalization, 251
gene cluster, 252–254
heterologous production, 249–254
pathway elucidation, 252
production challenges, 250–252
toxicity, 250
bioactive, 267
Secreted proteins, 148
Secretion signals, 243, 245
Secretome, 147
Secretory pathway, 49, 244–248
Selection markers, 234–238
Selection pressure, 376
Selective autophagy, 194, 195
Semi-continuous cultivation, 418
Senescence, 153–157
Sex-induced silencing (SIS), 110
Sexual development, 176, 177, 180–183, 186,
192, 195
Shock resistance, 389
Siderophores, 377, 378, 383
Signal peptide peptidases (SPP), 61
Signaling pathway, 151–153
SignalP, 211
Silent metabolic cluster, 268, 278
Simultaneous, 380
Small-interfering RNAs (siRNA), 153
Small RNA (sRNA), 158
SNARE protein, 126
Soft rots, 369–371, 373, 384–386, 391
Spitzenko ¨rper, 247
Splicing
unconventional, 52
Sporophores, 369, 388
26S proteasome, 178, 189, 190, 193–194, 196
Stain, 369, 370, 386–389, 391
Sterol regulatory element binding protein
(SREBP), 56
Subject Index
451
Promoters, 238, 273, 330–332, 354, 355
constitutive, 238
identification, 240–241
inducible, 238
natural, 238
synthetic, 241
Pro-sequence, 245
Protease deficient strains, 249
Proteases, 249, 406
Protein
misfolded, 50
Protein degradation, 190, 191, 193–196
Protein glycosylation, 246
Protein synthesis
building blocks, 248
Protein tags and linkers, 242–243
Protein therapeutics, 328
Proteolytic sites, 243
Proteomics, 284
Proximal LRE (pLRE), 85
Pseurotin, 274, 278
Psilocybin, 276
Purification tags, 243
Pyridine coenzymes, 376
Pyruvate (PYR), 340–346
Q
Quelling, 109
R
Race tube, 78, 94
Rapid amplification of cDNA ends (RACE), 251
Recalcitrant substrate, 375
Recombinant protein, 328, 330–332
Regulated Ire1-dependent decay (RIDD), 53
Remediation, 388–391
Repeat, 209
Repressed under secretion stress (RESS), 67
Resistance mechanism, 250
Resistant structure, 416
Rhizomorph, 379
Ribosomal genes (rDNA), 110
Rice, 152, 153
RIP homotypic interaction motif, 134
RNA interference, 13
RNA interference machinery (RNAi), 149
RNase, 50
S
Salt demand, 402
Sanger sequencing, 208
Saprophytes, 401
Sapwood, 369, 386–388, 391
SCF complex, 189, 191, 192
Sea water, 407
Secondary metabolites, 174–179, 181–183, 186–
188, 191, 192, 194–196, 212–213, 267, 320,
322, 324–328, 333, 404–405
biosynthetic gene cluster, 177, 186
biosynthetic pathways, 251
compartmentalization, 251
gene cluster, 252–254
heterologous production, 249–254
pathway elucidation, 252
production challenges, 250–252
toxicity, 250
bioactive, 267
Secreted proteins, 148
Secretion signals, 243, 245
Secretome, 147
Secretory pathway, 49, 244–248
Selection markers, 234–238
Selection pressure, 376
Selective autophagy, 194, 195
Semi-continuous cultivation, 418
Senescence, 153–157
Sex-induced silencing (SIS), 110
Sexual development, 176, 177, 180–183, 186,
192, 195
Shock resistance, 389
Siderophores, 377, 378, 383
Signal peptide peptidases (SPP), 61
Signaling pathway, 151–153
SignalP, 211
Silent metabolic cluster, 268, 278
Simultaneous, 380
Small-interfering RNAs (siRNA), 153
Small RNA (sRNA), 158
SNARE protein, 126
Soft rots, 369–371, 373, 384–386, 391
Spitzenko ¨rper, 247
Splicing
unconventional, 52
Sporophores, 369, 388
26S proteasome, 178, 189, 190, 193–194, 196
Stain, 369, 370, 386–389, 391
Sterol regulatory element binding protein
(SREBP), 56
Subject Index
451