Nakajima T, Ballou CE (1975) Yeast manno-protein
biosynthesis: solubilization and selective assay of
four mannosyltransferases. Proc Natl Acad Sci U S
A 72(10):3912–3916
Nielsen J, Larsson C, van Maris A, Pronk J (2013)
Metabolic engineering of yeast for production of
fuels and chemicals. Curr Opin Biotechnol 24
(3):398–404
Ornelas AP, Silveira WB, Sampaio FC, Passos FML
(2007) The activity of b-galactosidase and lactose
metabolism in Kluyveromyces lactis cultured in
cheese whey as a function of growth rate. J Appl
Microbiol 104:1008–1013
Otero JM, Cimini D, Patil KR, Poulsen SG, Olsson L,
Nielsen J (2013) Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid
cell factory. PLoS One 8(1):e54144
Pinazo JM, Domine ME, Parvulescu V, Petru F (2015)
Sustainability metrics for succinic acid production: a comparison between biomass-based and
petrochemical routes. Catal Today 239:17–24
Porro D, Bianchi MM, Brambilla L, Menghini R, Bolzani D, Carrera V, Lievense J, Liu CL, Ranzi BM,
Frontali L, Alberghina L (1999) Replacement of a
metabolic pathway for large-scale production of
lactic acid from engineered yeasts. Appl Environ
Microbiol 65(9):4211–4215
Pretorius IS, Boeke JD (2018) Yeast 2.0-connecting the
dots in the construction of the world’s first functional synthetic eukaryotic genome. FEMS Yeast
Res 18(4):foy032
Raab AM, Gebhardt G, Bolotina N, Weuster-Botz D,
Lang C (2010) Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid. Metab Eng 12(6):518–525
Rajgarhia V, Asleson Dundon C, Olson S, Suominen P,
Hause B (2007) Methods and materials for the
production of D-lactic acid in yeast. EP Patent
1513923 B1
Renewable Fuels Association (2017) World fuel ethanol
production.
https://ethanolrfaorg/resources/
industry/statistics/#1537559649968-e206480c7160. Cited 20 Mar 2019
Romero PA, Lussier M, Ve ´ronneau S, Sdicu AM, Herscovics A, Bussey H (1999) Mnt2p and Mnt3p of
Saccharomyces cerevisiae are members of the
Mnn1p family of alpha-1,3-mannosyltransferases
responsible for adding the terminal mannose residues of O-linked oligosaccharides. Glycobiology 9
(10):1045–1051
Roohvand F, Shokri M, Abdollahpour-Alitappeh M,
Ehsani P (2017) Biomedical applications of yeasta patent view, part one: yeasts as workhorses for
the production of therapeutics and vaccines.
Expert Opin Ther Pat 27(8):929–951
Rude MA, Schirmer A (2009) New microbial fuels: a
biotech perspective. Curr Opin Microbiol 12
(3):274–281
Sauer M, Porro D, Mattanovich D, Branduardi P (2010)
16 years research on lactic acid production with
yeast—ready for the market? Biotechnol Genet
Eng Rev 27:229–256
Schindler D, Dai J, Cai Y (2018) Synthetic genomics: a
new venture to dissect genome fundamentals and
engineer new functions. Curr Opin Chem Biol
46:56–62
Schmidt I, Schewe H, Gassel S, Jin C, Buckingham J,
Hu ¨mbelin M, Sandmann G, Schrader J (2011) Biotechnological production of astaxanthin with
Phaffia rhodozyma/Xanthophyllomyces dendrorhous. Appl Microbiol Biotechnol 89(3):555–571
Schotte P, Dewerte I, De Groeve M, De Keyser S, De
Brabandere V, Stanssens P (2016) Pichia pastoris
Mut(S) strains are prone to misincorporation of
O-methyl-L-homoserine at methionine residues
when methanol is used as the sole carbon source.
Microb Cell Factories 15:98
Shay LK, Hunt HR, Wegner GH (1987) Highproductivity fermentation process for cultivating
industrial microorganisms. J Ind Microbiol 2
(2):79–85
Shen CR, Lan EI, Dekishima Y, Baez A, Cho KM, Liao JC
(2011) Driving forces enable high-titer anaerobic
1-butanol synthesis in Escherichia coli. Appl Environ Microbiol 77(9):2905–2915
Shen XX, Opulente DA, Kominek J, Zhou X, Steenwyk
JL, Buh KV, Haase MAB, Wisecaver JH, Wang M,
Doering DT, Boudouris JT, Schneider RM, Langdon QK, Ohkuma M, Endoh R, Takashima M,
Manabe RI, C ˇ adez ˇ N, Libkind D, Rosa CA, DeVirgilio J, Hulfachor AB, Groenewald M, Kurtzman
CP, Hittinger CT, Rokas A (2018) Tempo and
mode of genome evolution in the budding yeast
subphylum. Cell 175(6):1533–1545.e1520
Siverio JM (2002) Assimilation of nitrate by yeasts.
FEMS Microbiol Rev 26(3):277–284
Song Y, Choi MH, Park JN, Kim MW, Kim EJ, Kang HA,
Kim JY (2007) Engineering of the yeast Yarrowia
lipolytica for the production of glycoproteins lacking the outer-chain mannose residues of Nglycans. Appl Environ Microbiol 73(14):4446–4454
Spadiut O, Capone S, Krainer F, Glieder A, Herwig C
(2014) Microbials for the production of monoclonal antibodies and antibody fragments. Trends
Biotechnol 32(1):54–60
Spohner SC, Schaum V, Quitmann H, Czermak P (2016)
Kluyveromyces lactis: an emerging tool in biotechnology. J Biotechnol 222:104–116
Stepie ´n PP, Brousseau R, Wu R, Narang S, Thomas DY
(1983) Synthesis of a human insulin gene. VI
Expression of the synthetic proinsulin gene in
yeast. Gene 24(2–3):289–297
Sua ´stegui M, Shao Z (2016) Yeast factories for the
production of aromatic compounds: from building
blocks to plant secondary metabolites. J Ind
Microbiol Biotechnol 43(11):1611–1624
336
B. Schmelzer et al.
biosynthesis: solubilization and selective assay of
four mannosyltransferases. Proc Natl Acad Sci U S
A 72(10):3912–3916
Nielsen J, Larsson C, van Maris A, Pronk J (2013)
Metabolic engineering of yeast for production of
fuels and chemicals. Curr Opin Biotechnol 24
(3):398–404
Ornelas AP, Silveira WB, Sampaio FC, Passos FML
(2007) The activity of b-galactosidase and lactose
metabolism in Kluyveromyces lactis cultured in
cheese whey as a function of growth rate. J Appl
Microbiol 104:1008–1013
Otero JM, Cimini D, Patil KR, Poulsen SG, Olsson L,
Nielsen J (2013) Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid
cell factory. PLoS One 8(1):e54144
Pinazo JM, Domine ME, Parvulescu V, Petru F (2015)
Sustainability metrics for succinic acid production: a comparison between biomass-based and
petrochemical routes. Catal Today 239:17–24
Porro D, Bianchi MM, Brambilla L, Menghini R, Bolzani D, Carrera V, Lievense J, Liu CL, Ranzi BM,
Frontali L, Alberghina L (1999) Replacement of a
metabolic pathway for large-scale production of
lactic acid from engineered yeasts. Appl Environ
Microbiol 65(9):4211–4215
Pretorius IS, Boeke JD (2018) Yeast 2.0-connecting the
dots in the construction of the world’s first functional synthetic eukaryotic genome. FEMS Yeast
Res 18(4):foy032
Raab AM, Gebhardt G, Bolotina N, Weuster-Botz D,
Lang C (2010) Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid. Metab Eng 12(6):518–525
Rajgarhia V, Asleson Dundon C, Olson S, Suominen P,
Hause B (2007) Methods and materials for the
production of D-lactic acid in yeast. EP Patent
1513923 B1
Renewable Fuels Association (2017) World fuel ethanol
production.
https://ethanolrfaorg/resources/
industry/statistics/#1537559649968-e206480c7160. Cited 20 Mar 2019
Romero PA, Lussier M, Ve ´ronneau S, Sdicu AM, Herscovics A, Bussey H (1999) Mnt2p and Mnt3p of
Saccharomyces cerevisiae are members of the
Mnn1p family of alpha-1,3-mannosyltransferases
responsible for adding the terminal mannose residues of O-linked oligosaccharides. Glycobiology 9
(10):1045–1051
Roohvand F, Shokri M, Abdollahpour-Alitappeh M,
Ehsani P (2017) Biomedical applications of yeasta patent view, part one: yeasts as workhorses for
the production of therapeutics and vaccines.
Expert Opin Ther Pat 27(8):929–951
Rude MA, Schirmer A (2009) New microbial fuels: a
biotech perspective. Curr Opin Microbiol 12
(3):274–281
Sauer M, Porro D, Mattanovich D, Branduardi P (2010)
16 years research on lactic acid production with
yeast—ready for the market? Biotechnol Genet
Eng Rev 27:229–256
Schindler D, Dai J, Cai Y (2018) Synthetic genomics: a
new venture to dissect genome fundamentals and
engineer new functions. Curr Opin Chem Biol
46:56–62
Schmidt I, Schewe H, Gassel S, Jin C, Buckingham J,
Hu ¨mbelin M, Sandmann G, Schrader J (2011) Biotechnological production of astaxanthin with
Phaffia rhodozyma/Xanthophyllomyces dendrorhous. Appl Microbiol Biotechnol 89(3):555–571
Schotte P, Dewerte I, De Groeve M, De Keyser S, De
Brabandere V, Stanssens P (2016) Pichia pastoris
Mut(S) strains are prone to misincorporation of
O-methyl-L-homoserine at methionine residues
when methanol is used as the sole carbon source.
Microb Cell Factories 15:98
Shay LK, Hunt HR, Wegner GH (1987) Highproductivity fermentation process for cultivating
industrial microorganisms. J Ind Microbiol 2
(2):79–85
Shen CR, Lan EI, Dekishima Y, Baez A, Cho KM, Liao JC
(2011) Driving forces enable high-titer anaerobic
1-butanol synthesis in Escherichia coli. Appl Environ Microbiol 77(9):2905–2915
Shen XX, Opulente DA, Kominek J, Zhou X, Steenwyk
JL, Buh KV, Haase MAB, Wisecaver JH, Wang M,
Doering DT, Boudouris JT, Schneider RM, Langdon QK, Ohkuma M, Endoh R, Takashima M,
Manabe RI, C ˇ adez ˇ N, Libkind D, Rosa CA, DeVirgilio J, Hulfachor AB, Groenewald M, Kurtzman
CP, Hittinger CT, Rokas A (2018) Tempo and
mode of genome evolution in the budding yeast
subphylum. Cell 175(6):1533–1545.e1520
Siverio JM (2002) Assimilation of nitrate by yeasts.
FEMS Microbiol Rev 26(3):277–284
Song Y, Choi MH, Park JN, Kim MW, Kim EJ, Kang HA,
Kim JY (2007) Engineering of the yeast Yarrowia
lipolytica for the production of glycoproteins lacking the outer-chain mannose residues of Nglycans. Appl Environ Microbiol 73(14):4446–4454
Spadiut O, Capone S, Krainer F, Glieder A, Herwig C
(2014) Microbials for the production of monoclonal antibodies and antibody fragments. Trends
Biotechnol 32(1):54–60
Spohner SC, Schaum V, Quitmann H, Czermak P (2016)
Kluyveromyces lactis: an emerging tool in biotechnology. J Biotechnol 222:104–116
Stepie ´n PP, Brousseau R, Wu R, Narang S, Thomas DY
(1983) Synthesis of a human insulin gene. VI
Expression of the synthetic proinsulin gene in
yeast. Gene 24(2–3):289–297
Sua ´stegui M, Shao Z (2016) Yeast factories for the
production of aromatic compounds: from building
blocks to plant secondary metabolites. J Ind
Microbiol Biotechnol 43(11):1611–1624
336
B. Schmelzer et al.