Swinkels BW, van Ooyen AJJ, Bonekamp FJ (1993) The
yeast Kluyveromyces lactis as an efficient host for
heterologous gene expression. Antonie Van Leeuwenhoek 64:187–201
Tang H, Song M, He Y, Wang J, Wang S, Shen Y, Hou J,
Bao X (2017) Engineering vesicle trafficking
improves the extracellular activity and surface display efficiency of cellulases in. Biotechnol Biofuels
10:53
Tang W, Wang Y, Zhang J, Cai Y, He Z (2019) Biosynthetic pathway of carotenoids in Rhodotorula and
strategies for enhanced their production. J Microbiol Biotechnol 29:507–517
Timoumi A, Guillouet SE, Molina-Jouve C, Fillaudeau
L, Gorret N (2018) Impacts of environmental conditions on product formation and morphology of
Yarrowia lipolytica. Appl Microbiol Biotechnol
102(9):3831–3848
van de Graaf MJ, Valianpoer F, Fiey G, Delattre L,
Schulten EAM (2015) Process for the crystallization of succinic acid. US patent US20150057425A1
van Ooyen AJJ, Dekker P, Huang M, Olsthoorn MMA,
Jacobs DI, Colussi PA, Taron CH (2006) Heterologous protein production in the yeast Kluyveromyces lactis. FEMS Yeast Res 6:381–392
van Zyl JH, Den Haan R, Van Zyl WH (2016) Overexpression of native Saccharomyces cerevisiae ERto-Golgi SNARE genes increased heterologous cellulase secretion. Appl Microbiol Biotechnol 100
(1):505–518
Vandermies M, Fickers P (2019) Bioreactor-scale strategies for the production of recombinant protein
in the yeast Yarrowia lipolytica. Microorganisms 7
(2):E40
Vasavada A (1995) Improving productivity of heterologous proteins in recombinant Saccharomyces cerevisiae fermentations. Adv Appl Microbiol 41:25–
54
Vieira Gomes AM, Souza Carmo T, Silva Carvalho L,
Mendonc ¸a Bahia F, Parachin NS (2018) Comparison of yeasts as hosts for recombinant protein
production. Microorganisms 6(2):E38
Walsh G (2014) Biopharmaceutical benchmarks 2014.
Nat Biotechnol 32(10):992–1000
Walsh G (2018) Biopharmaceutical benchmarks 2018.
Nat Biotechnol 36(12):1136–1145
Wang G, Huang M, Nielsen J (2017) Exploring the
potential of Saccharomyces cerevisiae for biopharmaceutical protein production. Curr Opin Biotechnol 48:77–84
Wegner GH (1990) Emerging applications of the
methylotrophic yeasts. FEMS Microbiol Rev 7(34):279–283
Wijeyaratne SC, Ohta K, Chavanich S, Mahamontri V,
Nilubol N, Hayashida S (1986) Lipid composition
of a thermotolerant yeast, Hansenula polymorpha.
Agric Biol Chem 50(4):827–832
Wirtz VJ (2016) Insulin market profile. Health Action
International, Amsterdam
Xie D, Miller E, Sharpe P, Jackson E, Zhu Q (2017)
Omega-3 production by fermentation of Yarrowia
lipolytica: from fed-batch to continuous. Biotechnol Bioeng 114(4):798–812
Xu L, Shen Y, Hou J, Peng B, Tang H, Bao X (2014)
Secretory pathway engineering enhances secretion
of cellobiohydrolase I from Trichoderma reesei in
Saccharomyces cerevisiae. J Biosci Bioeng 117
(1):45–52
Xue Z, Sharpe PL, Hong SP, Yadav NS, Xie D, Short DR,
Damude HG, Rupert RA, Seip JE, Wang J, Pollak
DW, Bostick MW, Bosak MD, Macool DJ, Hollerbach DH, Zhang H, Arcilla DM, Bledsoe SA, Croker K, McCord EF, Tyreus BD, Jackson EN, Zhu Q
(2013) Production of omega-3 eicosapentaenoic
acid by metabolic engineering of Yarrowia lipolytica. Nat Biotechnol 31(8):734–740
Yang Z, Zhang Z (2018) Engineering strategies for
enhanced production of protein and bio-products
in Pichia pastoris: a review. Biotechnol Adv 36
(1):182–195
Ye J, Ly J, Watts K, Hsu A, Walker A, McLaughlin K,
Berdichevsky M, Prinz B, Sean Kersey D, d’Anjou
M, Pollard D, Potgieter T (2011) Optimization of a
glycoengineered Pichia pastoris cultivation process for commercial antibody production. Biotechnol Prog 27(6):1744–1750
Yoo SJ, Moon HY, Kang HA (2019) Screening and
selection of production strains: secretory protein
expression and analysis in Hansenula polymorpha.
Methods Mol Biol 1923:133–151
Zahrl RJ, Gasser B, Mattanovich D, Ferrer P (2019)
Detection and elimination of cellular bottlenecks
in protein-producing yeasts. Methods Mol Biol
1923:75–95
13 Yeast Cell Factories
337
yeast Kluyveromyces lactis as an efficient host for
heterologous gene expression. Antonie Van Leeuwenhoek 64:187–201
Tang H, Song M, He Y, Wang J, Wang S, Shen Y, Hou J,
Bao X (2017) Engineering vesicle trafficking
improves the extracellular activity and surface display efficiency of cellulases in. Biotechnol Biofuels
10:53
Tang W, Wang Y, Zhang J, Cai Y, He Z (2019) Biosynthetic pathway of carotenoids in Rhodotorula and
strategies for enhanced their production. J Microbiol Biotechnol 29:507–517
Timoumi A, Guillouet SE, Molina-Jouve C, Fillaudeau
L, Gorret N (2018) Impacts of environmental conditions on product formation and morphology of
Yarrowia lipolytica. Appl Microbiol Biotechnol
102(9):3831–3848
van de Graaf MJ, Valianpoer F, Fiey G, Delattre L,
Schulten EAM (2015) Process for the crystallization of succinic acid. US patent US20150057425A1
van Ooyen AJJ, Dekker P, Huang M, Olsthoorn MMA,
Jacobs DI, Colussi PA, Taron CH (2006) Heterologous protein production in the yeast Kluyveromyces lactis. FEMS Yeast Res 6:381–392
van Zyl JH, Den Haan R, Van Zyl WH (2016) Overexpression of native Saccharomyces cerevisiae ERto-Golgi SNARE genes increased heterologous cellulase secretion. Appl Microbiol Biotechnol 100
(1):505–518
Vandermies M, Fickers P (2019) Bioreactor-scale strategies for the production of recombinant protein
in the yeast Yarrowia lipolytica. Microorganisms 7
(2):E40
Vasavada A (1995) Improving productivity of heterologous proteins in recombinant Saccharomyces cerevisiae fermentations. Adv Appl Microbiol 41:25–
54
Vieira Gomes AM, Souza Carmo T, Silva Carvalho L,
Mendonc ¸a Bahia F, Parachin NS (2018) Comparison of yeasts as hosts for recombinant protein
production. Microorganisms 6(2):E38
Walsh G (2014) Biopharmaceutical benchmarks 2014.
Nat Biotechnol 32(10):992–1000
Walsh G (2018) Biopharmaceutical benchmarks 2018.
Nat Biotechnol 36(12):1136–1145
Wang G, Huang M, Nielsen J (2017) Exploring the
potential of Saccharomyces cerevisiae for biopharmaceutical protein production. Curr Opin Biotechnol 48:77–84
Wegner GH (1990) Emerging applications of the
methylotrophic yeasts. FEMS Microbiol Rev 7(34):279–283
Wijeyaratne SC, Ohta K, Chavanich S, Mahamontri V,
Nilubol N, Hayashida S (1986) Lipid composition
of a thermotolerant yeast, Hansenula polymorpha.
Agric Biol Chem 50(4):827–832
Wirtz VJ (2016) Insulin market profile. Health Action
International, Amsterdam
Xie D, Miller E, Sharpe P, Jackson E, Zhu Q (2017)
Omega-3 production by fermentation of Yarrowia
lipolytica: from fed-batch to continuous. Biotechnol Bioeng 114(4):798–812
Xu L, Shen Y, Hou J, Peng B, Tang H, Bao X (2014)
Secretory pathway engineering enhances secretion
of cellobiohydrolase I from Trichoderma reesei in
Saccharomyces cerevisiae. J Biosci Bioeng 117
(1):45–52
Xue Z, Sharpe PL, Hong SP, Yadav NS, Xie D, Short DR,
Damude HG, Rupert RA, Seip JE, Wang J, Pollak
DW, Bostick MW, Bosak MD, Macool DJ, Hollerbach DH, Zhang H, Arcilla DM, Bledsoe SA, Croker K, McCord EF, Tyreus BD, Jackson EN, Zhu Q
(2013) Production of omega-3 eicosapentaenoic
acid by metabolic engineering of Yarrowia lipolytica. Nat Biotechnol 31(8):734–740
Yang Z, Zhang Z (2018) Engineering strategies for
enhanced production of protein and bio-products
in Pichia pastoris: a review. Biotechnol Adv 36
(1):182–195
Ye J, Ly J, Watts K, Hsu A, Walker A, McLaughlin K,
Berdichevsky M, Prinz B, Sean Kersey D, d’Anjou
M, Pollard D, Potgieter T (2011) Optimization of a
glycoengineered Pichia pastoris cultivation process for commercial antibody production. Biotechnol Prog 27(6):1744–1750
Yoo SJ, Moon HY, Kang HA (2019) Screening and
selection of production strains: secretory protein
expression and analysis in Hansenula polymorpha.
Methods Mol Biol 1923:133–151
Zahrl RJ, Gasser B, Mattanovich D, Ferrer P (2019)
Detection and elimination of cellular bottlenecks
in protein-producing yeasts. Methods Mol Biol
1923:75–95
13 Yeast Cell Factories
337