secretion by Saccharomyces cerevisiae. FEMS Yeast
Res 12(5):491–510
Hu W, Li WJ, Yang HQ, Chen JH (2019) Current strategies and future prospects for enhancing microbial production of citric acid. Appl Microbiol
Biotechnol 103(1):201–209
Huang CJ, Damasceno LM, Anderson KA, Zhang S, Old
LJ, Batt CA (2011) A proteomic analysis of the
Pichia pastoris secretome in methanol-induced
cultures. Appl Microbiol Biotechnol 90(1):235–247
IHS Markit (2015) Citric acid-chemical economics
handbook. IHS Markit, London
International Yeast Co. Ltd. (1933) Verfahren zur Herstellung von Hefe nach dem Zulaufverfahren. German patent DE583760 C
Ito Y, Hirasawa T, Shimizu H (2014) Metabolic engineering of Saccharomyces cerevisiae to improve
succinic acid production based on metabolic
profiling. Biosci Biotechnol Biochem 78(1):151–
159
Jansen MLA, Bracher JM, Papapetridis I, Verhoeven
MD, de Bruijn H, de Waal PP, van Maris AJA,
Klaassen P, Pronk JT (2017) Saccharomyces cerevisiae strains for second-generation ethanol production: from academic exploration to industrial
implementation. FEMS Yeast Res 17(5):fox044
Khanna S, Goyal A, Moholkar VS (2012) Microbial
conversion of glycerol: present status and future
prospects. Crit Rev Biotechnol 32(3):235–262
Kim MW, Rhee SK, Kim JY, Shimma Y, Chiba Y, Jigami
Y, Kang HA (2004) Characterization of N-linked
oligosaccharides assembled on secretory recombinant glucose oxidase and cell wall mannoproteins
from the methylotrophic yeast Hansenula polymorpha. Glycobiology 14(3):243–251
Kitagawa T, Kohda K, Tokuhiro K, Hoshida H, Akada
R, Takahashi H, Imaeda T (2011) Identification of
genes that enhance cellulase protein production in
yeast. J Biotechnol 151(2):194–203
Kjeldsen T (2000) Yeast secretory expression of insulin
precursors. Appl Microbiol Biotechnol 54(3):277–
286
Kjeldsen T, Pettersson AF, Hach M, Diers I, Havelund S,
Hansen PH, Andersen AS (1997) Synthetic leaders
with potential BiP binding mediate high-yield
secretion of correctly folded insulin precursors
from Saccharomyces cerevisiae. Protein Expr
Purif 9(3):331–336
Klein M, Swinnen S, Thevelein JM, Nevoigt E (2017)
Glycerol metabolism and transport in yeast and
fungi: established knowledge and ambiguities.
Environ Microbiol 19(3):878–893
Kung SH, Lund S, Murarka A, McPhee D, Paddon CJ
(2018) Approaches and recent developments for
the commercial production of semi-synthetic artemisinin. Front Plant Sci 9:87
Langer ES, Rader RA, Gillespie DE (eds) (2018)
Fifteenth annual report and survey of biopharmaceutical manufacturing capacity and production.
BioPlan Associates, Rockville, MD. isbn:978-1934106-33-4
Li M, Schneider K, Kristensen M, Borodina I, Nielsen J
(2016) Engineering yeast for high-level production
of stilbenoid antioxidants. Sci Rep 6:36827
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke
CD (2018) Complete biosynthesis of noscapine
and halogenated alkaloids in yeast. Proc Natl
Acad Sci U S A 115(17):E3922–E3931
Liu Y, Huang H (2018) Expression of single-domain
antibody in different systems. Appl Microbiol Biotechnol 102(2):539–551
Liu Z, Tyo KE, Martı ´nez JL, Petranovic D, Nielsen J
(2012) Different expression systems for production of recombinant proteins in Saccharomyces
cerevisiae. Biotechnol Bioeng 109(5):1259–1268
Maccani A, Landes N, Stadlmayr G, Maresch D, Leitner
C, Maurer M, Gasser B, Ernst W, Kunert R (2014)
Mattanovich D (2014) Pichia pastoris secretes
recombinant proteins less efficiently than Chinese
hamster ovary cells but allows higher space-time
yields for less complex proteins. Biotechnol J 9
(4):526–537
Madzak C (2015) Yarrowia lipolytica: recent achievements in heterologous protein expression and
pathway engineering. Appl Microbiol Biotechnol
99(11):4559–4577
Madzak C (2018) Engineering Yarrowia lipolytica for
use in biotechnological applications: a review of
major achievements and recent innovations. Mol
Biotechnol 60(8):621–635
Manfra ˜o-Netto JHC, Gomes AMV, Parachin NS (2019)
Advances in using Hansenula polymorpha as chassis for recombinant protein production. Front
Bioeng Biotechnol 7:94
Market Research Engine (2019) Specialty enzymes market expected to be worth US$ 6.50 billion by 2024.
cialty-enzymes-market-expected-to-be-worth-us55-billion-by-2022-2018-08-28. Cited 20 Mar 2019
Mata-Go ´mez LC, Montan ˜ez JC, Me ´ndez-Zavala A,
Aguilar CN (2014) Biotechnological production
of carotenoids by yeasts: an overview. Microb
Cell Factories 13:12
Meehl MA, Stadheim TA (2014) Biopharmaceutical discovery and production in yeast. Curr Opin Biotechnol 30:120–127
Mendoza-Vega O, Sabatie ´ J, Brown SW (1994) Industrial production of heterologous proteins by fedbatch cultures of the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 15(4):369–410
Miller C, Fosmer A, Rush B, McMullin T, Beacom D,
Suominen P (2011) Industrial production of lactic
acid. In: Moo-Young M (ed) Comprehensive biotechnology, 2nd edn. Academic Press, Burlington,
pp 179–188
Mori K (2015) The unfolded protein response: the dawn
of a new field. Proc Jpn Acad Ser B Phys Biol Sci 91
(9):469–480
13 Yeast Cell Factories
335
Res 12(5):491–510
Hu W, Li WJ, Yang HQ, Chen JH (2019) Current strategies and future prospects for enhancing microbial production of citric acid. Appl Microbiol
Biotechnol 103(1):201–209
Huang CJ, Damasceno LM, Anderson KA, Zhang S, Old
LJ, Batt CA (2011) A proteomic analysis of the
Pichia pastoris secretome in methanol-induced
cultures. Appl Microbiol Biotechnol 90(1):235–247
IHS Markit (2015) Citric acid-chemical economics
handbook. IHS Markit, London
International Yeast Co. Ltd. (1933) Verfahren zur Herstellung von Hefe nach dem Zulaufverfahren. German patent DE583760 C
Ito Y, Hirasawa T, Shimizu H (2014) Metabolic engineering of Saccharomyces cerevisiae to improve
succinic acid production based on metabolic
profiling. Biosci Biotechnol Biochem 78(1):151–
159
Jansen MLA, Bracher JM, Papapetridis I, Verhoeven
MD, de Bruijn H, de Waal PP, van Maris AJA,
Klaassen P, Pronk JT (2017) Saccharomyces cerevisiae strains for second-generation ethanol production: from academic exploration to industrial
implementation. FEMS Yeast Res 17(5):fox044
Khanna S, Goyal A, Moholkar VS (2012) Microbial
conversion of glycerol: present status and future
prospects. Crit Rev Biotechnol 32(3):235–262
Kim MW, Rhee SK, Kim JY, Shimma Y, Chiba Y, Jigami
Y, Kang HA (2004) Characterization of N-linked
oligosaccharides assembled on secretory recombinant glucose oxidase and cell wall mannoproteins
from the methylotrophic yeast Hansenula polymorpha. Glycobiology 14(3):243–251
Kitagawa T, Kohda K, Tokuhiro K, Hoshida H, Akada
R, Takahashi H, Imaeda T (2011) Identification of
genes that enhance cellulase protein production in
yeast. J Biotechnol 151(2):194–203
Kjeldsen T (2000) Yeast secretory expression of insulin
precursors. Appl Microbiol Biotechnol 54(3):277–
286
Kjeldsen T, Pettersson AF, Hach M, Diers I, Havelund S,
Hansen PH, Andersen AS (1997) Synthetic leaders
with potential BiP binding mediate high-yield
secretion of correctly folded insulin precursors
from Saccharomyces cerevisiae. Protein Expr
Purif 9(3):331–336
Klein M, Swinnen S, Thevelein JM, Nevoigt E (2017)
Glycerol metabolism and transport in yeast and
fungi: established knowledge and ambiguities.
Environ Microbiol 19(3):878–893
Kung SH, Lund S, Murarka A, McPhee D, Paddon CJ
(2018) Approaches and recent developments for
the commercial production of semi-synthetic artemisinin. Front Plant Sci 9:87
Langer ES, Rader RA, Gillespie DE (eds) (2018)
Fifteenth annual report and survey of biopharmaceutical manufacturing capacity and production.
BioPlan Associates, Rockville, MD. isbn:978-1934106-33-4
Li M, Schneider K, Kristensen M, Borodina I, Nielsen J
(2016) Engineering yeast for high-level production
of stilbenoid antioxidants. Sci Rep 6:36827
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke
CD (2018) Complete biosynthesis of noscapine
and halogenated alkaloids in yeast. Proc Natl
Acad Sci U S A 115(17):E3922–E3931
Liu Y, Huang H (2018) Expression of single-domain
antibody in different systems. Appl Microbiol Biotechnol 102(2):539–551
Liu Z, Tyo KE, Martı ´nez JL, Petranovic D, Nielsen J
(2012) Different expression systems for production of recombinant proteins in Saccharomyces
cerevisiae. Biotechnol Bioeng 109(5):1259–1268
Maccani A, Landes N, Stadlmayr G, Maresch D, Leitner
C, Maurer M, Gasser B, Ernst W, Kunert R (2014)
Mattanovich D (2014) Pichia pastoris secretes
recombinant proteins less efficiently than Chinese
hamster ovary cells but allows higher space-time
yields for less complex proteins. Biotechnol J 9
(4):526–537
Madzak C (2015) Yarrowia lipolytica: recent achievements in heterologous protein expression and
pathway engineering. Appl Microbiol Biotechnol
99(11):4559–4577
Madzak C (2018) Engineering Yarrowia lipolytica for
use in biotechnological applications: a review of
major achievements and recent innovations. Mol
Biotechnol 60(8):621–635
Manfra ˜o-Netto JHC, Gomes AMV, Parachin NS (2019)
Advances in using Hansenula polymorpha as chassis for recombinant protein production. Front
Bioeng Biotechnol 7:94
Market Research Engine (2019) Specialty enzymes market expected to be worth US$ 6.50 billion by 2024.
cialty-enzymes-market-expected-to-be-worth-us55-billion-by-2022-2018-08-28. Cited 20 Mar 2019
Mata-Go ´mez LC, Montan ˜ez JC, Me ´ndez-Zavala A,
Aguilar CN (2014) Biotechnological production
of carotenoids by yeasts: an overview. Microb
Cell Factories 13:12
Meehl MA, Stadheim TA (2014) Biopharmaceutical discovery and production in yeast. Curr Opin Biotechnol 30:120–127
Mendoza-Vega O, Sabatie ´ J, Brown SW (1994) Industrial production of heterologous proteins by fedbatch cultures of the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 15(4):369–410
Miller C, Fosmer A, Rush B, McMullin T, Beacom D,
Suominen P (2011) Industrial production of lactic
acid. In: Moo-Young M (ed) Comprehensive biotechnology, 2nd edn. Academic Press, Burlington,
pp 179–188
Mori K (2015) The unfolded protein response: the dawn
of a new field. Proc Jpn Acad Ser B Phys Biol Sci 91
(9):469–480
13 Yeast Cell Factories
335