Baghban R, Farajnia S, Rajabibazl M, Ghasemi Y, Mafi
A, Hoseinpoor R, Rahbarnia L, Aria M (2019)
Yeast expression systems: overview and recent
advances. Mol Biotechnol 61(5):365–384
Barredo JL, Garcı ´a-Estrada C, Kosalkova K, Barreiro C
(2017) Biosynthesis of astaxanthin as a main carotenoid in the Heterobasidiomycetous Yeast
Xanthophyllomyces dendrorhous. J Fungi (Basel)
3(3):44
Besada-Lombana PB, McTaggart TL, Da Silva NA
(2018) Molecular tools for pathway engineering
in Saccharomyces cerevisiae. Curr Opin Biotechnol
53:39–49
Breitenbach J, Pollmann H, Sandmann G (2019)
Genetic modification of the carotenoid pathway
in the red yeast Xanthophyllomyces dendrorhous:
engineering of a high-yield zeaxanthin strain. J
Biotechnol 289:112–117
Buijs NA, Siewers V, Nielsen J (2013) Advanced biofuel
production by the yeast Saccharomyces cerevisiae.
Curr Opin Chem Biol 17(3):480–488
Cavallo E, Charreau H, Cerrutti P, Foresti ML (2017)
Yarrowia lipolytica: a model yeast for citric acid
production. FEMS Yeast Res 17(8):fox084
Celin ´ska E, Nicaud JM (2019) Filamentous fungi-like
secretory pathway strayed in a yeast system: peculiarities of Yarrowia lipolytica secretory pathway
underlying its extraordinary performance. Appl
Microbiol Biotechnol 103(1):39–52
Chen X, Hagel JM, Chang L, Tucker JE, Shiigi SA,
Yelpaala Y, Chen HY, Estrada R, Colbeck J,
Enquist-Newman M, Iba ´n ˜ez AB, Cottarel G,
Vidanes GM, Facchini PJ (2018) A pathogenesisrelated 10 protein catalyzes the final step in thebaine biosynthesis. Nat Chem Biol 14(7):738–743
Ciriminna R, Meneguzzo F, Delisi R, Pagliaro M (2017)
Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J 11(1):22
Currie JN (1917) The citric acid fermentation of Aspergillus niger. J Biol Chem 31(1):15–37
De Wachter C, Van Landuyt L, Callewaert N (2018)
Engineering of yeast glycoprotein expression.
Adv Biochem Eng Biotechnol. https://doi.org/
10.1007/10_2018_69
Dellomonaco C, Clomburg JM, Miller EN, Gonzalez R
(2011) Engineered reversal of the b-oxidation
cycle for the synthesis of fuels and chemicals.
Nature 476(7360):355–359
Dewan SS (2014) Global markets for enzymes in industrial applications. BIO0300J. BBC Research, Wellesley, MA
Diers IV, Rasmussen E, Larsen PH, Kjaersig IL (1991)
Yeast fermentation processes for insulin production. Bioprocess Technol 13:166–176
Duina AA, Miller ME, Keeney JB (2014) Budding yeast
for budding geneticists: a primer on the Saccharomyces cerevisiae model system. Genetics 197
(1):33–48
Du ¨rre P (2007) Biobutanol: an attractive biofuel. Biotechnol J 2(12):1525–1534
Egermeier M, Russmayer H, Sauer M, Marx H (2017)
Metabolic flexibility of Yarrowia lipolytica growing on glycerol. Front Microbiol 8:49
Feyder S, De Craene JO, Ba ¨r S, Bertazzi DL, Friant S
(2015) Membrane trafficking in the yeast Saccharomyces cerevisiae model. Int J Mol Sci 16(1):1509–
1525
Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante
M, Smolke CD (2015) Complete biosynthesis of
opioids in yeast. Science 349(6252):1095–1100
Gemmill TR, Trimble RB (1999) Overview of N- and Olinked oligosaccharide structures found in various
yeast species. Biochim Biophys Acta 1426(2):227–
237
Generoso WC, Schadeweg V, Oreb M, Boles E (2015)
Metabolic engineering of Saccharomyces cerevisiae
for production of butanol isomers. Curr Opin Biotechnol 33:1–7
Global Industry Analysts, Inc. (2017) The global market
for lactic acid is projected to reach 1.6 million
metric tons by 2024. https://strategyr.blogspot.
com/2017/06/the-global-market-for-lactic-acid-is.
html. Cited 20 Mar 2019
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B,
Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with
6000 genes. Science 274 (5287):546, 563–547
Groenewald M, Boekhout T, Neuve ´glise C, Gaillardin C,
van Dijck PW, Wyss M (2014) Yarrowia lipolytica:
safety assessment of an oleaginous yeast with a
great industrial potential. Crit Rev Microbiol 40
(3):187–206
Gu ¨ndu ¨z Ergu ¨n B, Hu ¨ccetog ˘ulları D, O ¨ ztu ¨rk S, C ¸ elik E,
C ¸ alık P (2019) Established and upcoming yeast
expression systems. Methods Mol Biol 1923:1–74
Hale V, Keasling JD, Renninger N, Diagana TT (2007)
Microbially derived artemisinin: a biotechnology
solution to the global problem of access to affordable antimalarial drugs. Am J Trop Med Hyg 77(6
Suppl):198–202
Hamilton SR, Gerngross TU (2007) Glycosylation engineering in yeast: the advent of fully humanized
yeast. Curr Opin Biotechnol 18(5):387–392
Hamilton SR, Davidson RC, Sethuraman N, Nett JH,
Jiang Y, Rios S, Bobrowicz P, Stadheim TA, Li H,
Choi BK, Hopkins D, Wischnewski H, Roser J,
Mitchell T, Strawbridge RR, Hoopes J, Wildt S,
Gerngross TU (2006) Humanization of yeast to
produce complex terminally sialylated glycoproteins. Science 313(5792):1441–1443
Hitzeman RA, Hagie FE, Levine HL, Goeddel DV,
Ammerer G, Hall BD (1981) Expression of a
human gene for interferon in yeast. Nature 293
(5835):717–722
Ho ¨hne M, Kabisch J (2016) Brewing painkillers: a yeast
cell factory for the production of opioids from
sugar. Angew Chem Int Ed Engl 55(4):1248–1250
Hou J, Tyo KE, Liu Z, Petranovic D, Nielsen J (2012)
Metabolic engineering of recombinant protein
334
B. Schmelzer et al.
A, Hoseinpoor R, Rahbarnia L, Aria M (2019)
Yeast expression systems: overview and recent
advances. Mol Biotechnol 61(5):365–384
Barredo JL, Garcı ´a-Estrada C, Kosalkova K, Barreiro C
(2017) Biosynthesis of astaxanthin as a main carotenoid in the Heterobasidiomycetous Yeast
Xanthophyllomyces dendrorhous. J Fungi (Basel)
3(3):44
Besada-Lombana PB, McTaggart TL, Da Silva NA
(2018) Molecular tools for pathway engineering
in Saccharomyces cerevisiae. Curr Opin Biotechnol
53:39–49
Breitenbach J, Pollmann H, Sandmann G (2019)
Genetic modification of the carotenoid pathway
in the red yeast Xanthophyllomyces dendrorhous:
engineering of a high-yield zeaxanthin strain. J
Biotechnol 289:112–117
Buijs NA, Siewers V, Nielsen J (2013) Advanced biofuel
production by the yeast Saccharomyces cerevisiae.
Curr Opin Chem Biol 17(3):480–488
Cavallo E, Charreau H, Cerrutti P, Foresti ML (2017)
Yarrowia lipolytica: a model yeast for citric acid
production. FEMS Yeast Res 17(8):fox084
Celin ´ska E, Nicaud JM (2019) Filamentous fungi-like
secretory pathway strayed in a yeast system: peculiarities of Yarrowia lipolytica secretory pathway
underlying its extraordinary performance. Appl
Microbiol Biotechnol 103(1):39–52
Chen X, Hagel JM, Chang L, Tucker JE, Shiigi SA,
Yelpaala Y, Chen HY, Estrada R, Colbeck J,
Enquist-Newman M, Iba ´n ˜ez AB, Cottarel G,
Vidanes GM, Facchini PJ (2018) A pathogenesisrelated 10 protein catalyzes the final step in thebaine biosynthesis. Nat Chem Biol 14(7):738–743
Ciriminna R, Meneguzzo F, Delisi R, Pagliaro M (2017)
Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J 11(1):22
Currie JN (1917) The citric acid fermentation of Aspergillus niger. J Biol Chem 31(1):15–37
De Wachter C, Van Landuyt L, Callewaert N (2018)
Engineering of yeast glycoprotein expression.
Adv Biochem Eng Biotechnol. https://doi.org/
10.1007/10_2018_69
Dellomonaco C, Clomburg JM, Miller EN, Gonzalez R
(2011) Engineered reversal of the b-oxidation
cycle for the synthesis of fuels and chemicals.
Nature 476(7360):355–359
Dewan SS (2014) Global markets for enzymes in industrial applications. BIO0300J. BBC Research, Wellesley, MA
Diers IV, Rasmussen E, Larsen PH, Kjaersig IL (1991)
Yeast fermentation processes for insulin production. Bioprocess Technol 13:166–176
Duina AA, Miller ME, Keeney JB (2014) Budding yeast
for budding geneticists: a primer on the Saccharomyces cerevisiae model system. Genetics 197
(1):33–48
Du ¨rre P (2007) Biobutanol: an attractive biofuel. Biotechnol J 2(12):1525–1534
Egermeier M, Russmayer H, Sauer M, Marx H (2017)
Metabolic flexibility of Yarrowia lipolytica growing on glycerol. Front Microbiol 8:49
Feyder S, De Craene JO, Ba ¨r S, Bertazzi DL, Friant S
(2015) Membrane trafficking in the yeast Saccharomyces cerevisiae model. Int J Mol Sci 16(1):1509–
1525
Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante
M, Smolke CD (2015) Complete biosynthesis of
opioids in yeast. Science 349(6252):1095–1100
Gemmill TR, Trimble RB (1999) Overview of N- and Olinked oligosaccharide structures found in various
yeast species. Biochim Biophys Acta 1426(2):227–
237
Generoso WC, Schadeweg V, Oreb M, Boles E (2015)
Metabolic engineering of Saccharomyces cerevisiae
for production of butanol isomers. Curr Opin Biotechnol 33:1–7
Global Industry Analysts, Inc. (2017) The global market
for lactic acid is projected to reach 1.6 million
metric tons by 2024. https://strategyr.blogspot.
com/2017/06/the-global-market-for-lactic-acid-is.
html. Cited 20 Mar 2019
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B,
Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with
6000 genes. Science 274 (5287):546, 563–547
Groenewald M, Boekhout T, Neuve ´glise C, Gaillardin C,
van Dijck PW, Wyss M (2014) Yarrowia lipolytica:
safety assessment of an oleaginous yeast with a
great industrial potential. Crit Rev Microbiol 40
(3):187–206
Gu ¨ndu ¨z Ergu ¨n B, Hu ¨ccetog ˘ulları D, O ¨ ztu ¨rk S, C ¸ elik E,
C ¸ alık P (2019) Established and upcoming yeast
expression systems. Methods Mol Biol 1923:1–74
Hale V, Keasling JD, Renninger N, Diagana TT (2007)
Microbially derived artemisinin: a biotechnology
solution to the global problem of access to affordable antimalarial drugs. Am J Trop Med Hyg 77(6
Suppl):198–202
Hamilton SR, Gerngross TU (2007) Glycosylation engineering in yeast: the advent of fully humanized
yeast. Curr Opin Biotechnol 18(5):387–392
Hamilton SR, Davidson RC, Sethuraman N, Nett JH,
Jiang Y, Rios S, Bobrowicz P, Stadheim TA, Li H,
Choi BK, Hopkins D, Wischnewski H, Roser J,
Mitchell T, Strawbridge RR, Hoopes J, Wildt S,
Gerngross TU (2006) Humanization of yeast to
produce complex terminally sialylated glycoproteins. Science 313(5792):1441–1443
Hitzeman RA, Hagie FE, Levine HL, Goeddel DV,
Ammerer G, Hall BD (1981) Expression of a
human gene for interferon in yeast. Nature 293
(5835):717–722
Ho ¨hne M, Kabisch J (2016) Brewing painkillers: a yeast
cell factory for the production of opioids from
sugar. Angew Chem Int Ed Engl 55(4):1248–1250
Hou J, Tyo KE, Liu Z, Petranovic D, Nielsen J (2012)
Metabolic engineering of recombinant protein
334
B. Schmelzer et al.