Rokas A, Wisecaver JH, Lind AL (2018) The birth,
evolution and death of metabolic gene clusters in
fungi. Nat Rev Microbiol 16:731–744
Roze LV, Arthur AE, Hong S-Y, Chanda A, Linz JE
(2007) The initiation and pattern of spread of
histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin
cluster. Mol Microbiol 66:713–726
Roze LV, Chanda A, Linz JE (2011a) Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular
processes. Fungal Genet Biol 48:35–48
Roze LV, Koptina AV, Laivenieks M, Beaudry RM,
Jones DA, Kanarsky AV, Linz JE, Roze LV, Linz
JE, Koptina AV, Kanarsky AV, Laivenieks M,
Beaudry RM, Jones DA (2011b) Willow volatiles
influence growth, development, and secondary
metabolism in Aspergillus parasiticus. Appl Microbiol Biotechnol 92:359–370
Ruger-Herreros C, Rodrı ´guez-Romero J, FernándezBarranco R, Olmedo M, Fischer R, Corrochano
LM, Canovas D (2011) Regulation of conidiation
by light in Aspergillus nidulans. Genetics 188:809–
822
Sakai K, Kinoshita H, Nihira T (2012) Heterologous
expression system in Aspergillus oryzae for fungal
biosynthetic gene clusters of secondary metabolites. Appl Microbiol Biotechnol 93:2011–2022
Sarikaya-Bayram O ¨ , Bayram O ¨ , Feussner K, Kim JH,
Kim HS, Kaever A, Feussner I, Chae KS, Han DM,
Han KH, Braus GH (2014) Membrane-bound
methyltransferase complex VapA-VipC-VapB
guides epigenetic control of fungal development.
Dev Cell 29:406–420
Sarikaya-Bayram O ¨ , Palmer JM, Keller N, Braus GH,
Bayram O ¨ (2015) One Juliet and four Romeos: VeA
and its methyltransferases. Front Microbiol 6:1
Satterlee T, Cary JW, Calvo AM (2016) RmtA, a putative
arginine methyltransferase, regulates secondary
metabolism and development in Aspergillus flavus.
PLoS One 11:e0155575
Schardl CL, Panaccione DG, Tudzynski P (2006) Ergot
alkaloids-biology and molecular biology. In:
Cordell GA (ed) The alkaloids.chemistry and biology, vol 63, 1st edn. Academic Press, Cambridge,
pp 45–86
Scharf DH, Brakhage AA, Mukherjee PK (2016) Gliotoxin—bane or boon? Environ Microbiol 18:1096–
1109
Schinke J, Gulko MK, Christmann M, Valerius O,
Stumpf K, Stirz M, Braus GH (2016) The DenA/
DEN1 interacting phosphatase DipA controls
septa positioning and phosphorylation-dependent
stability of cytoplasmatic DenA/DEN1 during fungal development. PLoS Genet 12:e1005949
Schmidt-Dannert C (2014) Biosynthesis of terpenoid
natural products in fungi. In: Schrader JBJ (ed)
Biotechnology of isoprenoids, Advances in biochemical engineering/biotechnology, vol 148.
Springer, Cham, pp 19–61
Sela N, Atir-lande A, Kornitzer D (2012) Neddylation
and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans. Eukaryot
Cell 11:42–52
Shelest E (2017) Transcription factors in fungi: TFome
dynamics, three major families, and dualspecificity TFs. Front Genet 8:53
Shilatifard A (2012) The COMPASS family of histone
H3K4 methylases: mechanisms of regulation in
development and disease pathogenesis. Annu Rev
Biochem 81:65–95
Shimizu K, Hicks JK, Huang T, Keller NP (2003) Pka,
Ras and RGS protein interactions regulate activity
of AflR, a Zn(II)2Cys6 transcription factor in
Aspergillus nidulans. Genetics 1104:1095–1104
Shimizu M, Masuo S, Fujita T, Doi Y, Kamimura Y,
Takaya N (2012) Hydrolase controls cellular
NAD, sirtuin, and secondary metabolites. Mol
Cell Biol 32:3743–3755
Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer
RA, Braus GH, Sharon A, Hohl TM (2017) Sterilizing immunity in the lung relies on targeting fungal
apoptosis-like programmed cell death. Science
357:1037–1041
Shoji J, Kikuma T, Arioka M, Kitamoto K (2010)
Macroautophagy-mediated degradation of whole
nuclei in the filamentous fungus Aspergillus oryzae. PLoS One 5:e15650
Shwab EK, Bok JW, Tribus M, Galehr J, Graessle S,
Keller NP (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot
Cell 6:1656–1664
Soukup AA, Chiang Y-M, Woo Bok J, ReyesDominguez Y, Oakley BR, Wang CCC, Strauss J,
Keller NP (2012) Overexpression of the Aspergillus
nidulans histone 4 acetyltransferase EsaA
increases activation of secondary metabolite production. Mol Microbiol 86:314–330
Spasser L, Brik A (2012) Chemistry and biology of the
ubiquitin signal. Angew Chem 51:6840–6862
Spatafora JW, Aime MC, Grigoriev IV, Martin F, Stajich
JE, Blackwell M (2017) The fungal tree of life: from
molecular systematics to genome-scale phylogenies. Microbiol Spectr 5:5
Stergiopoulos I, Collemare J, Mehrabi R, de Wit PJGM
(2013) Phytotoxic secondary metabolites and peptides produced by plant pathogenic Dothideomycete fungi. FEMS Microbiol Rev 37:67–93
Stjepanovic G, Baskaran S, Lin MG, Hurley JH (2017)
Vps34 kinase domain dynamics regulate the
autophagic PI 3-kinase complex. Mol Cell 67:528–
534
Stopa N, Krebs JE, Shechter D (2015) The PRMT5
arginine methyltransferase: many roles in development, cancer and beyond. Cell Mol Life Sci
72:2041–2059
8 Coordination of Fungal Secondary Metabolism and Development
203
evolution and death of metabolic gene clusters in
fungi. Nat Rev Microbiol 16:731–744
Roze LV, Arthur AE, Hong S-Y, Chanda A, Linz JE
(2007) The initiation and pattern of spread of
histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin
cluster. Mol Microbiol 66:713–726
Roze LV, Chanda A, Linz JE (2011a) Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular
processes. Fungal Genet Biol 48:35–48
Roze LV, Koptina AV, Laivenieks M, Beaudry RM,
Jones DA, Kanarsky AV, Linz JE, Roze LV, Linz
JE, Koptina AV, Kanarsky AV, Laivenieks M,
Beaudry RM, Jones DA (2011b) Willow volatiles
influence growth, development, and secondary
metabolism in Aspergillus parasiticus. Appl Microbiol Biotechnol 92:359–370
Ruger-Herreros C, Rodrı ´guez-Romero J, FernándezBarranco R, Olmedo M, Fischer R, Corrochano
LM, Canovas D (2011) Regulation of conidiation
by light in Aspergillus nidulans. Genetics 188:809–
822
Sakai K, Kinoshita H, Nihira T (2012) Heterologous
expression system in Aspergillus oryzae for fungal
biosynthetic gene clusters of secondary metabolites. Appl Microbiol Biotechnol 93:2011–2022
Sarikaya-Bayram O ¨ , Bayram O ¨ , Feussner K, Kim JH,
Kim HS, Kaever A, Feussner I, Chae KS, Han DM,
Han KH, Braus GH (2014) Membrane-bound
methyltransferase complex VapA-VipC-VapB
guides epigenetic control of fungal development.
Dev Cell 29:406–420
Sarikaya-Bayram O ¨ , Palmer JM, Keller N, Braus GH,
Bayram O ¨ (2015) One Juliet and four Romeos: VeA
and its methyltransferases. Front Microbiol 6:1
Satterlee T, Cary JW, Calvo AM (2016) RmtA, a putative
arginine methyltransferase, regulates secondary
metabolism and development in Aspergillus flavus.
PLoS One 11:e0155575
Schardl CL, Panaccione DG, Tudzynski P (2006) Ergot
alkaloids-biology and molecular biology. In:
Cordell GA (ed) The alkaloids.chemistry and biology, vol 63, 1st edn. Academic Press, Cambridge,
pp 45–86
Scharf DH, Brakhage AA, Mukherjee PK (2016) Gliotoxin—bane or boon? Environ Microbiol 18:1096–
1109
Schinke J, Gulko MK, Christmann M, Valerius O,
Stumpf K, Stirz M, Braus GH (2016) The DenA/
DEN1 interacting phosphatase DipA controls
septa positioning and phosphorylation-dependent
stability of cytoplasmatic DenA/DEN1 during fungal development. PLoS Genet 12:e1005949
Schmidt-Dannert C (2014) Biosynthesis of terpenoid
natural products in fungi. In: Schrader JBJ (ed)
Biotechnology of isoprenoids, Advances in biochemical engineering/biotechnology, vol 148.
Springer, Cham, pp 19–61
Sela N, Atir-lande A, Kornitzer D (2012) Neddylation
and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans. Eukaryot
Cell 11:42–52
Shelest E (2017) Transcription factors in fungi: TFome
dynamics, three major families, and dualspecificity TFs. Front Genet 8:53
Shilatifard A (2012) The COMPASS family of histone
H3K4 methylases: mechanisms of regulation in
development and disease pathogenesis. Annu Rev
Biochem 81:65–95
Shimizu K, Hicks JK, Huang T, Keller NP (2003) Pka,
Ras and RGS protein interactions regulate activity
of AflR, a Zn(II)2Cys6 transcription factor in
Aspergillus nidulans. Genetics 1104:1095–1104
Shimizu M, Masuo S, Fujita T, Doi Y, Kamimura Y,
Takaya N (2012) Hydrolase controls cellular
NAD, sirtuin, and secondary metabolites. Mol
Cell Biol 32:3743–3755
Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer
RA, Braus GH, Sharon A, Hohl TM (2017) Sterilizing immunity in the lung relies on targeting fungal
apoptosis-like programmed cell death. Science
357:1037–1041
Shoji J, Kikuma T, Arioka M, Kitamoto K (2010)
Macroautophagy-mediated degradation of whole
nuclei in the filamentous fungus Aspergillus oryzae. PLoS One 5:e15650
Shwab EK, Bok JW, Tribus M, Galehr J, Graessle S,
Keller NP (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot
Cell 6:1656–1664
Soukup AA, Chiang Y-M, Woo Bok J, ReyesDominguez Y, Oakley BR, Wang CCC, Strauss J,
Keller NP (2012) Overexpression of the Aspergillus
nidulans histone 4 acetyltransferase EsaA
increases activation of secondary metabolite production. Mol Microbiol 86:314–330
Spasser L, Brik A (2012) Chemistry and biology of the
ubiquitin signal. Angew Chem 51:6840–6862
Spatafora JW, Aime MC, Grigoriev IV, Martin F, Stajich
JE, Blackwell M (2017) The fungal tree of life: from
molecular systematics to genome-scale phylogenies. Microbiol Spectr 5:5
Stergiopoulos I, Collemare J, Mehrabi R, de Wit PJGM
(2013) Phytotoxic secondary metabolites and peptides produced by plant pathogenic Dothideomycete fungi. FEMS Microbiol Rev 37:67–93
Stjepanovic G, Baskaran S, Lin MG, Hurley JH (2017)
Vps34 kinase domain dynamics regulate the
autophagic PI 3-kinase complex. Mol Cell 67:528–
534
Stopa N, Krebs JE, Shechter D (2015) The PRMT5
arginine methyltransferase: many roles in development, cancer and beyond. Cell Mol Life Sci
72:2041–2059
8 Coordination of Fungal Secondary Metabolism and Development
203