weck C, Strauss J, Brakhage AA (2011) Bacteriainduced natural product formation in the fungus
Aspergillus nidulans requires Saga/Ada-mediated
histone acetylation. Proc Natl Acad Sci USA
108:14282–14287
Oakley CE, Ahuja M, Sun W, Entwistle R, Akashi T,
Yaegashi J, Guo C, Cerqueira GC, Wortman JR,
Clay C, Wang C, Chiang Y, Oakley BR (2016)
Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Mol Microbiol
103:347–365
Oh Y, Franck WL, Han SO, Shows A, Gokce E, Muddiman DC, Dean RA (2012) Polyubiquitin is
required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.
PLoS One 7:e42868
Okada BK, Seyedsayamdost MR (2017) Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS
Microbiol Rev 41:19–33
Palmer JM, Bok JW, Lee S, Dagenais TRT, Andes DR,
Kontoyiannis DP, Keller NP (2013a) Loss of CclA,
required for histone 3 lysine 4 methylation,
decreases growth but increases secondary metabolite production in Aspergillus fumigatus. PeerJ 1:
e4
Palmer JM, Theisen JM, Duran RM, Grayburn WS,
Calvo AM, Keller NP (2013b) Secondary metabolism and development is mediated by LlmF control
of VeA subcellular localization in Aspergillus nidulans. PLoS Genet 9:e1003193
Park HS, Yu JH (2012) Genetic control of asexual sporulation in filamentous fungi. Curr Opin Microbiol
15:669–677
Parzych KR, Ariosa A, Mari M, Klionsky DJ (2018) A
newly characterized vacuolar serine carboxypeptidase, Atg42/Ybr139w, is required for normal vacuole function and the terminal steps of autophagy
in the yeast Saccharomyces cerevisiae. Mol Biol
Cell 29:1089–1099
Patananan AN, Palmer JM, Garvey GS, Keller NP,
Clarke SG (2013) A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine. J Biol Chem
288:14032–14045
Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D,
Marsischky G, Roelofs J, Finley D, Gygi SP (2003)
A proteomics approach to understanding protein
ubiquitination. Nat Biotechnol 21:921–926
Pfannenstiel BT, Greco C, Sukowaty AT, Keller NP
(2018) The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus. Fungal
Genet Biol 120:9–18
Pidroni A, Faber B, Brosch G, Bauer I, Graessle S (2018)
A class 1 histone deacetylase as major regulator of
secondary metabolite production in Aspergillus
nidulans. Front Microbiol 9:2212
Po ¨ggeler S, Nowrousian M, Teichert I, Beier A, Ku ¨ck U
(2018) Fruiting-body development in ascomycetes. In: Anke T, Schu ¨ffler A (eds) The Mycota
XV. Physiology and genetics, 2nd edn. Springer
International Publishing, Cham, pp 1–56
Popova B, Kleinknecht A, Arendarski P, Mischke J,
Wang D, Braus GH (2018) Sumoylation protects
against b-synuclein toxicity in yeast. Front Mol
Neurosci 11:94
Purschwitz J, Mu ¨ller S, Kastner C, Scho ¨ser M, Haas H,
Espeso EA, Atoui A, Calvo AM, Fischer R (2008)
Functional and physical interaction of blue- and
red-light sensors in Aspergillus nidulans. Curr Biol
18:255–259
Ramya V, Rajasekharan R (2016) ATG15 encodes a
phospholipase and is transcriptionally regulated
by YAP1 in Saccharomyces cerevisiae. FEBS Lett
590:3155–3167
Rauscher S, Pacher S, Hedtke M, Kniemeyer O, Fischer
R (2016) A phosphorylation code of the Aspergillus
nidulans global regulator VelvetA (VeA) determines specific functions. Mol Microbiol 99:909–
924
Reggiori F, Komatsu M, Finley K, Simonsen A (2012)
Autophagy: more than a nonselective pathway. Int
J Cell Biol 2012:1–18
Rehman SAA, Kristariyanto YA, Choi S, Labib K, Hofmann K, Kulathu Y, Arif S, Rehman A, Kristariyanto YA, Choi S, Nkosi PJ, Weidlich S (2016)
MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. Mol Cell 63:146–155
Ren H, Wang B, Zhao H (2017) Breaking the silence:
new strategies for discovering novel natural products. Curr Opin Biotechnol 48:21–27
Reyes-Dominguez Y, Bok JW, Berger H, Shwab EK,
Basheer A, Gallmetzer A, Scazzocchio C, Keller N,
Strauss J (2010) Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol
Microbiol 76:1376–1386
Richie DL, Askew DS (2008) Autophagy: a role in metal
ion homeostasis? Autophagy 4:115–117
Richie DL, Fuller KK, Fortwendel J, Miley MD,
McCarthy JW, Feldmesser M, Rhodes JC, Askew
DS (2007) Unexpected link between metal ion
deficiency and autophagy in Aspergillus fumigatus.
Eukaryot Cell 6:2437–2447
Riquelme M, Aguirre J, Bartnicki-Garcı ´a S, Braus GH,
Feldbru ¨gge M, Fleig U, Hansberg W, HerreraEstrella A, Ka ¨mper J, Ku ¨ck U, Mourin ˜o-Pe ´rez RR,
Takeshita N, Fischer R (2018) Fungal morphogenesis, from the polarized growth of hyphae to complex reproduction and infection structures.
Microbiol Mol Biol Rev 82:e00068–e00017
Rodriguez-Romero J, Hedtke M, Kastner C, Mu ¨ller S,
Fischer R (2010) Fungi, hidden in soil or up in the
air: light makes a difference. Annu Rev Microbiol
64:585–610
Rodrı ´guez-Urra AB, Jime ´nez C, Nieto MI, Rodrı ´guez J,
Hayashi H, Ugalde U (2012) Signaling the induction of sporulation involves the interaction of two
secondary metabolites in Aspergillus nidulans.
ACS Chem Biol 7:599–606
202
J. Gerke et al.
Aspergillus nidulans requires Saga/Ada-mediated
histone acetylation. Proc Natl Acad Sci USA
108:14282–14287
Oakley CE, Ahuja M, Sun W, Entwistle R, Akashi T,
Yaegashi J, Guo C, Cerqueira GC, Wortman JR,
Clay C, Wang C, Chiang Y, Oakley BR (2016)
Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Mol Microbiol
103:347–365
Oh Y, Franck WL, Han SO, Shows A, Gokce E, Muddiman DC, Dean RA (2012) Polyubiquitin is
required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.
PLoS One 7:e42868
Okada BK, Seyedsayamdost MR (2017) Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS
Microbiol Rev 41:19–33
Palmer JM, Bok JW, Lee S, Dagenais TRT, Andes DR,
Kontoyiannis DP, Keller NP (2013a) Loss of CclA,
required for histone 3 lysine 4 methylation,
decreases growth but increases secondary metabolite production in Aspergillus fumigatus. PeerJ 1:
e4
Palmer JM, Theisen JM, Duran RM, Grayburn WS,
Calvo AM, Keller NP (2013b) Secondary metabolism and development is mediated by LlmF control
of VeA subcellular localization in Aspergillus nidulans. PLoS Genet 9:e1003193
Park HS, Yu JH (2012) Genetic control of asexual sporulation in filamentous fungi. Curr Opin Microbiol
15:669–677
Parzych KR, Ariosa A, Mari M, Klionsky DJ (2018) A
newly characterized vacuolar serine carboxypeptidase, Atg42/Ybr139w, is required for normal vacuole function and the terminal steps of autophagy
in the yeast Saccharomyces cerevisiae. Mol Biol
Cell 29:1089–1099
Patananan AN, Palmer JM, Garvey GS, Keller NP,
Clarke SG (2013) A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine. J Biol Chem
288:14032–14045
Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D,
Marsischky G, Roelofs J, Finley D, Gygi SP (2003)
A proteomics approach to understanding protein
ubiquitination. Nat Biotechnol 21:921–926
Pfannenstiel BT, Greco C, Sukowaty AT, Keller NP
(2018) The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus. Fungal
Genet Biol 120:9–18
Pidroni A, Faber B, Brosch G, Bauer I, Graessle S (2018)
A class 1 histone deacetylase as major regulator of
secondary metabolite production in Aspergillus
nidulans. Front Microbiol 9:2212
Po ¨ggeler S, Nowrousian M, Teichert I, Beier A, Ku ¨ck U
(2018) Fruiting-body development in ascomycetes. In: Anke T, Schu ¨ffler A (eds) The Mycota
XV. Physiology and genetics, 2nd edn. Springer
International Publishing, Cham, pp 1–56
Popova B, Kleinknecht A, Arendarski P, Mischke J,
Wang D, Braus GH (2018) Sumoylation protects
against b-synuclein toxicity in yeast. Front Mol
Neurosci 11:94
Purschwitz J, Mu ¨ller S, Kastner C, Scho ¨ser M, Haas H,
Espeso EA, Atoui A, Calvo AM, Fischer R (2008)
Functional and physical interaction of blue- and
red-light sensors in Aspergillus nidulans. Curr Biol
18:255–259
Ramya V, Rajasekharan R (2016) ATG15 encodes a
phospholipase and is transcriptionally regulated
by YAP1 in Saccharomyces cerevisiae. FEBS Lett
590:3155–3167
Rauscher S, Pacher S, Hedtke M, Kniemeyer O, Fischer
R (2016) A phosphorylation code of the Aspergillus
nidulans global regulator VelvetA (VeA) determines specific functions. Mol Microbiol 99:909–
924
Reggiori F, Komatsu M, Finley K, Simonsen A (2012)
Autophagy: more than a nonselective pathway. Int
J Cell Biol 2012:1–18
Rehman SAA, Kristariyanto YA, Choi S, Labib K, Hofmann K, Kulathu Y, Arif S, Rehman A, Kristariyanto YA, Choi S, Nkosi PJ, Weidlich S (2016)
MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. Mol Cell 63:146–155
Ren H, Wang B, Zhao H (2017) Breaking the silence:
new strategies for discovering novel natural products. Curr Opin Biotechnol 48:21–27
Reyes-Dominguez Y, Bok JW, Berger H, Shwab EK,
Basheer A, Gallmetzer A, Scazzocchio C, Keller N,
Strauss J (2010) Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol
Microbiol 76:1376–1386
Richie DL, Askew DS (2008) Autophagy: a role in metal
ion homeostasis? Autophagy 4:115–117
Richie DL, Fuller KK, Fortwendel J, Miley MD,
McCarthy JW, Feldmesser M, Rhodes JC, Askew
DS (2007) Unexpected link between metal ion
deficiency and autophagy in Aspergillus fumigatus.
Eukaryot Cell 6:2437–2447
Riquelme M, Aguirre J, Bartnicki-Garcı ´a S, Braus GH,
Feldbru ¨gge M, Fleig U, Hansberg W, HerreraEstrella A, Ka ¨mper J, Ku ¨ck U, Mourin ˜o-Pe ´rez RR,
Takeshita N, Fischer R (2018) Fungal morphogenesis, from the polarized growth of hyphae to complex reproduction and infection structures.
Microbiol Mol Biol Rev 82:e00068–e00017
Rodriguez-Romero J, Hedtke M, Kastner C, Mu ¨ller S,
Fischer R (2010) Fungi, hidden in soil or up in the
air: light makes a difference. Annu Rev Microbiol
64:585–610
Rodrı ´guez-Urra AB, Jime ´nez C, Nieto MI, Rodrı ´guez J,
Hayashi H, Ugalde U (2012) Signaling the induction of sporulation involves the interaction of two
secondary metabolites in Aspergillus nidulans.
ACS Chem Biol 7:599–606
202
J. Gerke et al.