exchange mechanism enables variation in F-box
protein expression. Mol Cell 69:773–786.e6
Lo Presti L, Lanver D, Schweizer G, Tanaka S, Liang L,
Tollot M, Zuccaro A, Reissmann S, Kahmann R
(2015) Fungal effectors and plant susceptibility.
Annu Rev Plant Biol 66:513–545
Lo ´pez-Dı ´az C, Rahjoo V, Sulyok M, Ghionna V, Martı ´nVicente A, Capilla J, Di Pietro A, Lo ´pez-Berges MS
(2018) Fusaric acid contributes to virulence of
Fusarium oxysporum on plant and mammalian
hosts. Mol Plant Pathol 19:440–453
Lynch-Day MA, Klionsky DJ (2010) The Cvt pathway as
a model for selective autophagy. FEBS Lett
584:1359–1366
Macheleidt J, Mattern DJ, Fischer J, Netzker T, Weber J,
Schroeckh V, Valiante V, Brakhage AA (2016)
Regulation and role of fungal secondary metabolites. Annu Rev Genet 50:371–392
Magotra A, Kumar M, Kushwaha M, Awasthi P, Raina
C, Gupta AP, Shah BA, Gandhi SG, Chaubey A
(2017) Epigenetic modifier induced enhancement
of fumiquinazoline C production in Aspergillus
fumigatus (GA-L7): an endophytic fungus from
Grewia asiatica L. AMB Express 7:43
Malzahn E, Ciprianidis S, Káldi K, Schafmeier T, Brunner M (2010) Photoadaptation in Neurospora by
competitive interaction of activating and inhibitory LOV domains. Cell 142:762–772
Marı ´n I (2009) Diversification of the cullin family. BMC
Evol Biol 11:1–11
Matsuda Y, Abe I (2016) Biosynthesis of fungal meroterpenoids. Nat Prod Rep 33:26–53
McGrath JP, Jentsch S, Varshavsky A (1991) Uba1: an
essential yeast gene encoding ubiquitin-activating
enzyme. EMBO J 10:227–236
Meeks JJ, Shilatifard A (2017) Multiple roles for the
MLL/COMPASS family in the epigenetic regulation of gene expression and in cancer. Annu Rev
Cancer Biol 1:425–446
Meijer WH, Gidijala L, Fekken S, Kiel JAKW, van den
Berg MA, Lascaris R, Bovenberg RAL, van der Klei
IJ (2010) Peroxisomes are required for efficient
penicillin biosynthesis in Penicillium chrysogenum. Appl Environ Microbiol 76:5702–5709
Meister C, Gulko MK, Ko ¨hler AM, Braus GH (2016) The
devil is in the details: comparison between COP9
signalosome (CSN) and the LID of the 26S proteasome. Curr Genet 62:129–136
Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, de Vries RP, Haarmann T,
Hansen K, Hertz-Fowler C, Krappmann S, Mortensen UH, Pen ˜alva MA, Ram AFJ, Head RM (2016)
Current challenges of research on filamentous
fungi in relation to human welfare and a sustainable bio-economy: a white paper. Fungal Biol Biotechnol 3:6
Mukaiyama H, Nakase M, Nakamura T, Kakinuma Y,
Takegawa K (2010) Autophagy in the fission yeast
Schizosaccharomyces pombe. FEBS Lett 584:1327–
1334
Nahlik K, Dumkow M, Bayram O ¨ , Helmstaedt K, Busch
S, Valerius O, Gerke J, Hoppert M, Schwier E,
Opitz L, Westermann M, Grond S, Feussner K,
Goebel C, Kaever A, Meinicke P, Feussner I,
Braus GH (2010) The COP9 signalosome mediates
transcriptional and metabolic response to hormones, oxidative stress protection and cell wall
rearrangement during fungal development. Mol
Microbiol 78:964–979
Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR,
Dokmanovic M, Dorsey JA, Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger
SL (2006) Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows
dynamic interplay with positive-acting histone
modifications. Genes Dev 20:966–976
Netzker T, Fischer J, Weber J, Mattern DJ, Ko ¨nig CC,
Valiante V, Schroeckh V, Brakhage AA (2015)
Microbial communication leading to the activation of silent fungal secondary metabolite gene
clusters. Front Microbiol 6:299
Newman DJ, Cragg GM (2012) Natural products as
sources of new drugs over the 30 years from 1981
to 2010. J Nat Prod 75:311–335
Ni M, Yu JH (2007) A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus
nidulans. PLoS One 2:e970
Nie X, Li B, Wang S (2018) Epigenetic and posttranslational modifications in regulating the biology of
Aspergillus species. In: Gadd GM, Sariaslani S
(eds) Advances in applied microbiology. Academic Press, London, pp 191–226
Nitsche BM, Burggraaf-van Welzen A-M, Lamers G,
Meyer V, Ram AFJ (2013) Autophagy promotes
survival in aging submerged cultures of the filamentous fungus Aspergillus niger. Appl Microbiol
Biotechnol 97:8205–8218
Nocedal I, Mancera E, Johnson AD (2017) Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator. Elife 6:
e23250
Nolting N, Bernhards Y, Po ¨ggeler S (2009) SmATG7 is
required for viability in the homothallic ascomycete Sordaria macrospora. Fungal Genet Biol
46:531–542
Noventa-Jorda ˜o MA, Mendes do Nascimento A, Goldman MHS, Terenzi HF, Goldman GH (2000)
Molecular characterization of ubiquitin genes
from Aspergillus nidulans: mRNA expression on
different stress and growth conditions. Biochim
Biophys Acta Mol Cell Res 1490:237–244
Nowak SJ, Corces VG (2004) Phosphorylation of histone H3: a balancing act between chromosome
condensation and transcriptional activation.
Trends Genet 20:214–220
Nsa IY, Karunarathna N, Liu X, Huang H, Boetteger B,
Bell-Pedersen D (2015) A novel cryptochromedependent oscillator in Neurospora crassa. Genetics 199:233–245
Nu ¨tzmann H-W, Reyes-Dominguez Y, Scherlach K,
Schroeckh V, Horn F, Gacek A, Schu ¨mann J, Hert8 Coordination of Fungal Secondary Metabolism and Development
201
protein expression. Mol Cell 69:773–786.e6
Lo Presti L, Lanver D, Schweizer G, Tanaka S, Liang L,
Tollot M, Zuccaro A, Reissmann S, Kahmann R
(2015) Fungal effectors and plant susceptibility.
Annu Rev Plant Biol 66:513–545
Lo ´pez-Dı ´az C, Rahjoo V, Sulyok M, Ghionna V, Martı ´nVicente A, Capilla J, Di Pietro A, Lo ´pez-Berges MS
(2018) Fusaric acid contributes to virulence of
Fusarium oxysporum on plant and mammalian
hosts. Mol Plant Pathol 19:440–453
Lynch-Day MA, Klionsky DJ (2010) The Cvt pathway as
a model for selective autophagy. FEBS Lett
584:1359–1366
Macheleidt J, Mattern DJ, Fischer J, Netzker T, Weber J,
Schroeckh V, Valiante V, Brakhage AA (2016)
Regulation and role of fungal secondary metabolites. Annu Rev Genet 50:371–392
Magotra A, Kumar M, Kushwaha M, Awasthi P, Raina
C, Gupta AP, Shah BA, Gandhi SG, Chaubey A
(2017) Epigenetic modifier induced enhancement
of fumiquinazoline C production in Aspergillus
fumigatus (GA-L7): an endophytic fungus from
Grewia asiatica L. AMB Express 7:43
Malzahn E, Ciprianidis S, Káldi K, Schafmeier T, Brunner M (2010) Photoadaptation in Neurospora by
competitive interaction of activating and inhibitory LOV domains. Cell 142:762–772
Marı ´n I (2009) Diversification of the cullin family. BMC
Evol Biol 11:1–11
Matsuda Y, Abe I (2016) Biosynthesis of fungal meroterpenoids. Nat Prod Rep 33:26–53
McGrath JP, Jentsch S, Varshavsky A (1991) Uba1: an
essential yeast gene encoding ubiquitin-activating
enzyme. EMBO J 10:227–236
Meeks JJ, Shilatifard A (2017) Multiple roles for the
MLL/COMPASS family in the epigenetic regulation of gene expression and in cancer. Annu Rev
Cancer Biol 1:425–446
Meijer WH, Gidijala L, Fekken S, Kiel JAKW, van den
Berg MA, Lascaris R, Bovenberg RAL, van der Klei
IJ (2010) Peroxisomes are required for efficient
penicillin biosynthesis in Penicillium chrysogenum. Appl Environ Microbiol 76:5702–5709
Meister C, Gulko MK, Ko ¨hler AM, Braus GH (2016) The
devil is in the details: comparison between COP9
signalosome (CSN) and the LID of the 26S proteasome. Curr Genet 62:129–136
Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, de Vries RP, Haarmann T,
Hansen K, Hertz-Fowler C, Krappmann S, Mortensen UH, Pen ˜alva MA, Ram AFJ, Head RM (2016)
Current challenges of research on filamentous
fungi in relation to human welfare and a sustainable bio-economy: a white paper. Fungal Biol Biotechnol 3:6
Mukaiyama H, Nakase M, Nakamura T, Kakinuma Y,
Takegawa K (2010) Autophagy in the fission yeast
Schizosaccharomyces pombe. FEBS Lett 584:1327–
1334
Nahlik K, Dumkow M, Bayram O ¨ , Helmstaedt K, Busch
S, Valerius O, Gerke J, Hoppert M, Schwier E,
Opitz L, Westermann M, Grond S, Feussner K,
Goebel C, Kaever A, Meinicke P, Feussner I,
Braus GH (2010) The COP9 signalosome mediates
transcriptional and metabolic response to hormones, oxidative stress protection and cell wall
rearrangement during fungal development. Mol
Microbiol 78:964–979
Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR,
Dokmanovic M, Dorsey JA, Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger
SL (2006) Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows
dynamic interplay with positive-acting histone
modifications. Genes Dev 20:966–976
Netzker T, Fischer J, Weber J, Mattern DJ, Ko ¨nig CC,
Valiante V, Schroeckh V, Brakhage AA (2015)
Microbial communication leading to the activation of silent fungal secondary metabolite gene
clusters. Front Microbiol 6:299
Newman DJ, Cragg GM (2012) Natural products as
sources of new drugs over the 30 years from 1981
to 2010. J Nat Prod 75:311–335
Ni M, Yu JH (2007) A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus
nidulans. PLoS One 2:e970
Nie X, Li B, Wang S (2018) Epigenetic and posttranslational modifications in regulating the biology of
Aspergillus species. In: Gadd GM, Sariaslani S
(eds) Advances in applied microbiology. Academic Press, London, pp 191–226
Nitsche BM, Burggraaf-van Welzen A-M, Lamers G,
Meyer V, Ram AFJ (2013) Autophagy promotes
survival in aging submerged cultures of the filamentous fungus Aspergillus niger. Appl Microbiol
Biotechnol 97:8205–8218
Nocedal I, Mancera E, Johnson AD (2017) Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator. Elife 6:
e23250
Nolting N, Bernhards Y, Po ¨ggeler S (2009) SmATG7 is
required for viability in the homothallic ascomycete Sordaria macrospora. Fungal Genet Biol
46:531–542
Noventa-Jorda ˜o MA, Mendes do Nascimento A, Goldman MHS, Terenzi HF, Goldman GH (2000)
Molecular characterization of ubiquitin genes
from Aspergillus nidulans: mRNA expression on
different stress and growth conditions. Biochim
Biophys Acta Mol Cell Res 1490:237–244
Nowak SJ, Corces VG (2004) Phosphorylation of histone H3: a balancing act between chromosome
condensation and transcriptional activation.
Trends Genet 20:214–220
Nsa IY, Karunarathna N, Liu X, Huang H, Boetteger B,
Bell-Pedersen D (2015) A novel cryptochromedependent oscillator in Neurospora crassa. Genetics 199:233–245
Nu ¨tzmann H-W, Reyes-Dominguez Y, Scherlach K,
Schroeckh V, Horn F, Gacek A, Schu ¨mann J, Hert8 Coordination of Fungal Secondary Metabolism and Development
201