Strauss J, Reyes-Dominguez Y (2011) Regulation of
secondary metabolism by chromatin structure
and epigenetic codes. Fungal Genet Biol 48:62–69
Studt L, Janevska S, Arndt B, Boedi S, Sulyok M, Humpf
HU, Tudzynski B, Strauss J (2017) Lack of the
COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic
Fusarium species. Front Microbiol 7:2144
Sugimoto N, Iwaki T, Chardwiriyapreecha S, Shimazu
M, Kawano M, Sekito T, Takegawa K, Kakinuma Y
(2011) Atg22p, a vacuolar membrane protein
involved in the amino acid compartmentalization
of Schizosaccharomyces pombe. Biosci Biotechnol
Biochem 75:385–387
Sun ZW, Allis CD (2002) Ubiquitination of histone H2B
regulates H3 methylation and gene silencing in
yeast. Nature 418:104–108
Sun H, Wang W, Che Y, Jiang X (2016) Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line.
Mycology 7:81–87
Swaminathan S, Amerik AY, Hochstrasser M (1999)
The Doa4 deubiquitinating enzyme is required
for ubiquitin homeostasis in yeast. Mol Biol Cell
10:2583–2594
Tan KK (1974) Blue-light inhibition of sporulation in
Botrytis cinerea. J Gen Microbiol 82:191–200
Thieme KG, Gerke J, Sasse C, Valerius O, Thieme S,
Karimi R, Heinrich AK, Finkernagel F, Smith K,
Bode HB, Freitag M, Ram AFJ, Braus GH (2018)
Velvet domain protein VosA represses the zinc
cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary
metabolism. PLoS Genet 14:e1007511
Toledo AV, Franco MEE, Yanil Lopez SM, Troncozo
MI, Saparrat MCN, Balatti PA (2017) Melanins in
fungi: types, localization and putative biological
roles. Physiol Mol Plant Pathol 99:2–6
Tomko RJ, Hochstrasser M (2013) Molecular architecture and assembly of the eukaryotic proteasome.
Annu Rev Biochem 82:415–445
Tribus M, Bauer I, Galehr J, Rieser G, Trojer P, Brosch
G, Loidl P, Haas H, Graessle S (2010) A novel motif
in fungal class 1 histone deacetylases is essential
for growth and development of Aspergillus. Mol
Biol Cell 21:345–353
Tsitsigiannis DI, Zarnowski R, Keller NP (2004) The
lipid body protein, PpoA, coordinates sexual and
asexual sporulation in Aspergillus nidulans. J Biol
Chem 279:11344–11353
Tyler JK, Johnson JE (2018) The role of autophagy in
the regulation of yeast life span. Ann N Y Acad Sci
1418:31–43
van der Lee TAJ, Medema MH (2016) Computational
strategies for genome-based natural product discovery and engineering in fungi. Fungal Genet Biol
89:29–36
VanderMolen KM, Darveaux BA, Chen W-L, Swanson
SM, Pearce CJ, Oberlies NH (2014) Epigenetic
manipulation of a filamentous fungus by the
proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite.
RSC Adv 4:18329–18335
Voigt O, Po ¨ggeler S (2013) Autophagy genes Smatg8
and Smatg4 are required for fruiting-body development, vegetative growth and ascospore germination in the filamentous ascomycete Sordaria
macrospora. Autophagy 9:33–49
von Zeska Kress MR, Harting R, Bayram O ¨ , Christmann
M, Irmer H, Valerius O, Schinke J, Goldman GH,
Braus GH (2012) The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3
RING ligases during fungal development. Mol
Microbiol 83:1162–1177
Wagner EJ, Carpenter PB (2012) Understanding the
language of Lys36 methylation at histone H3. Nat
Rev Mol Cell Biol 13:115–126
Waite KA, De-La Mota-Peynado A, Vontz G, Roelofs J
(2016) Starvation induces proteasome autophagy
with different pathways for core and regulatory
particles. J Biol Chem 291:3239–3253
Wang J, Hu Q, Chen H, Zhou Z, Li W, Wang Y, Li S, He
Q (2010) Role of individual subunits of the Neurospora crassa CSN complex in regulation of
deneddylation and stability of cullin proteins.
PLoS Genet 6:12–16
Wang Y, Kim S-G, Wu J, Yu S, Kang K-Y, Kim S-T
(2011) Proteasome inhibitors affect appressorium
formation and pathogenicity of the rice blast fungus, Magnaporthe oryzae. Plant Pathol J 27:225–
231
Wang Z, Wang J, Li N, Li J, Trail F, Dunlap JC, Townsend JP (2018) Light sensing by opsins and fungal
ecology: NOP-1 modulates entry into sexual reproduction in response to environmental cues. Mol
Ecol 27:216–232
Wen X, Klionsky DJ (2016) An overview of macroautophagy in yeast. J Mol Biol 428:1681–1699
Werner A, Herzog B, Voigt O, Valerius O, Braus GH,
Po ¨ggeler S (2019) NBR1 is involved in selective
pexophagy in filamentous ascomycetes and can
be functionally replaced by a tagged version of its
human homolog. Autophagy 15:78–97
Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller
NP, Humpf HU, Tudzynski B (2010) FfVel1 and
Fflae1, components of a velvet-like complex in
Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Mol Microbiol
77:972–994
Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH (2008) Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem
6:1895–1897
Wolf JC, Mirocha CJ (1977) Control of sexual reproduction in Gibberella zeae (Fusarium roseum “Graminearum”). Appl Environ Microbiol 33:546–550
204
J. Gerke et al.
secondary metabolism by chromatin structure
and epigenetic codes. Fungal Genet Biol 48:62–69
Studt L, Janevska S, Arndt B, Boedi S, Sulyok M, Humpf
HU, Tudzynski B, Strauss J (2017) Lack of the
COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic
Fusarium species. Front Microbiol 7:2144
Sugimoto N, Iwaki T, Chardwiriyapreecha S, Shimazu
M, Kawano M, Sekito T, Takegawa K, Kakinuma Y
(2011) Atg22p, a vacuolar membrane protein
involved in the amino acid compartmentalization
of Schizosaccharomyces pombe. Biosci Biotechnol
Biochem 75:385–387
Sun ZW, Allis CD (2002) Ubiquitination of histone H2B
regulates H3 methylation and gene silencing in
yeast. Nature 418:104–108
Sun H, Wang W, Che Y, Jiang X (2016) Fungal secondary metabolites rasfonin induces autophagy, apoptosis and necroptosis in renal cancer cell line.
Mycology 7:81–87
Swaminathan S, Amerik AY, Hochstrasser M (1999)
The Doa4 deubiquitinating enzyme is required
for ubiquitin homeostasis in yeast. Mol Biol Cell
10:2583–2594
Tan KK (1974) Blue-light inhibition of sporulation in
Botrytis cinerea. J Gen Microbiol 82:191–200
Thieme KG, Gerke J, Sasse C, Valerius O, Thieme S,
Karimi R, Heinrich AK, Finkernagel F, Smith K,
Bode HB, Freitag M, Ram AFJ, Braus GH (2018)
Velvet domain protein VosA represses the zinc
cluster transcription factor SclB regulatory network for Aspergillus nidulans asexual development, oxidative stress response and secondary
metabolism. PLoS Genet 14:e1007511
Toledo AV, Franco MEE, Yanil Lopez SM, Troncozo
MI, Saparrat MCN, Balatti PA (2017) Melanins in
fungi: types, localization and putative biological
roles. Physiol Mol Plant Pathol 99:2–6
Tomko RJ, Hochstrasser M (2013) Molecular architecture and assembly of the eukaryotic proteasome.
Annu Rev Biochem 82:415–445
Tribus M, Bauer I, Galehr J, Rieser G, Trojer P, Brosch
G, Loidl P, Haas H, Graessle S (2010) A novel motif
in fungal class 1 histone deacetylases is essential
for growth and development of Aspergillus. Mol
Biol Cell 21:345–353
Tsitsigiannis DI, Zarnowski R, Keller NP (2004) The
lipid body protein, PpoA, coordinates sexual and
asexual sporulation in Aspergillus nidulans. J Biol
Chem 279:11344–11353
Tyler JK, Johnson JE (2018) The role of autophagy in
the regulation of yeast life span. Ann N Y Acad Sci
1418:31–43
van der Lee TAJ, Medema MH (2016) Computational
strategies for genome-based natural product discovery and engineering in fungi. Fungal Genet Biol
89:29–36
VanderMolen KM, Darveaux BA, Chen W-L, Swanson
SM, Pearce CJ, Oberlies NH (2014) Epigenetic
manipulation of a filamentous fungus by the
proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite.
RSC Adv 4:18329–18335
Voigt O, Po ¨ggeler S (2013) Autophagy genes Smatg8
and Smatg4 are required for fruiting-body development, vegetative growth and ascospore germination in the filamentous ascomycete Sordaria
macrospora. Autophagy 9:33–49
von Zeska Kress MR, Harting R, Bayram O ¨ , Christmann
M, Irmer H, Valerius O, Schinke J, Goldman GH,
Braus GH (2012) The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3
RING ligases during fungal development. Mol
Microbiol 83:1162–1177
Wagner EJ, Carpenter PB (2012) Understanding the
language of Lys36 methylation at histone H3. Nat
Rev Mol Cell Biol 13:115–126
Waite KA, De-La Mota-Peynado A, Vontz G, Roelofs J
(2016) Starvation induces proteasome autophagy
with different pathways for core and regulatory
particles. J Biol Chem 291:3239–3253
Wang J, Hu Q, Chen H, Zhou Z, Li W, Wang Y, Li S, He
Q (2010) Role of individual subunits of the Neurospora crassa CSN complex in regulation of
deneddylation and stability of cullin proteins.
PLoS Genet 6:12–16
Wang Y, Kim S-G, Wu J, Yu S, Kang K-Y, Kim S-T
(2011) Proteasome inhibitors affect appressorium
formation and pathogenicity of the rice blast fungus, Magnaporthe oryzae. Plant Pathol J 27:225–
231
Wang Z, Wang J, Li N, Li J, Trail F, Dunlap JC, Townsend JP (2018) Light sensing by opsins and fungal
ecology: NOP-1 modulates entry into sexual reproduction in response to environmental cues. Mol
Ecol 27:216–232
Wen X, Klionsky DJ (2016) An overview of macroautophagy in yeast. J Mol Biol 428:1681–1699
Werner A, Herzog B, Voigt O, Valerius O, Braus GH,
Po ¨ggeler S (2019) NBR1 is involved in selective
pexophagy in filamentous ascomycetes and can
be functionally replaced by a tagged version of its
human homolog. Autophagy 15:78–97
Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller
NP, Humpf HU, Tudzynski B (2010) FfVel1 and
Fflae1, components of a velvet-like complex in
Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Mol Microbiol
77:972–994
Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH (2008) Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem
6:1895–1897
Wolf JC, Mirocha CJ (1977) Control of sexual reproduction in Gibberella zeae (Fusarium roseum “Graminearum”). Appl Environ Microbiol 33:546–550
204
J. Gerke et al.