60
The combination of iron salts with macrocyclic polyamine (MCPA) ligands played
a key role in the reaction. N-heterocyclic compounds, such as pyrrole and pyridine,
used as both the substrate and solvent in the transformation. Notably, this procedure
is highly regioselective. The arylation of substituted pyrroles gave only 2-arylation
products without the formation of 3-arylation products, while the arylation of pyridine provided phenylated product at the 2-position as the major product.
Based on the preliminary mechanistic studies and DFT calculations, a catalytic
cycle of this iron-catalyzed direct oxidative cross-coupling has been proposed
Scheme 3.26 Fe-mediated oxidative cross-coupling of unactivated arenes with arylboronic acids
Scheme 3.27 Fe-mediated oxidative cross-coupling of N-heterocycles with arylboronic acids
C. He
The combination of iron salts with macrocyclic polyamine (MCPA) ligands played
a key role in the reaction. N-heterocyclic compounds, such as pyrrole and pyridine,
used as both the substrate and solvent in the transformation. Notably, this procedure
is highly regioselective. The arylation of substituted pyrroles gave only 2-arylation
products without the formation of 3-arylation products, while the arylation of pyridine provided phenylated product at the 2-position as the major product.
Based on the preliminary mechanistic studies and DFT calculations, a catalytic
cycle of this iron-catalyzed direct oxidative cross-coupling has been proposed
Scheme 3.26 Fe-mediated oxidative cross-coupling of unactivated arenes with arylboronic acids
Scheme 3.27 Fe-mediated oxidative cross-coupling of N-heterocycles with arylboronic acids
C. He