toluene, reflux
90%
78%
88%
75%
56%
75%
86%
90%
92%
R
O
H
Ar 1
Ar 2 B
O
O
Me
Me
RuH 2 (CO)(PPh 3 ) 3 (2 mol%)
R
O
Ar 2
Ar 1
Me
O
Ph
CF 3
t Bu
O
Ph
MeO
t Bu
O
Ph
F
Me
O
Ph
O
Ph
Ph
O
t Bu
O
t Bu
O
t Bu
O
F
NMe 2
Scheme 3.11 Ruthenium-catalyzed oxidative cross-coupling between aromatic ketones and
arylboronates
Ru
Me
O
H
Ru
O
Me
H
Ru
O
Me
O
Me
Ph
O
Me
Ph
Ph B
O
O
Me
Me
Ru
O
Me
Ph
Me
O
Ph
B
O
O
Me
Me
O
Ph
Me
A
C
B
D
E
Scheme 3.12 Proposed mechanism of the oxidative cross-coupling between aromatic ketones and
arylboronates