157
Scheme 5.2 The general mechanism of thermal energy-driven dehydrogenative Heck-type crosscoupling reactions
N
H
H
R 2
R 1
+
Ph
Ph
[MnBr(CO) 5 ] (10 mol%)
N
R 2
Ph
Ph
R 1
1
2
4
N
Ph
Ph
R
R
4a: R = OMe, 89 %
4b: R = F, 75 %
4c: R = H, 63 %
N
R
Ph
Ph
N
Ph
Ph
Me
Me
Me
R
4d: R = n Bu, 86 %
4e: R = i Pr, 82 %
4f: R = s Bu, 87 %
4g: R = OMe, 93 %
4h: R = NMe 2 , 97 %
+
H 2
1,4-dioxane (0.1 M)
105 °C, 12 h
Scheme 5.3 Manganese-catalyzed annulation of imines and alkynes
5 Fourth-Generation Oxidative Cross-Coupling Reactions
Scheme 5.2 The general mechanism of thermal energy-driven dehydrogenative Heck-type crosscoupling reactions
N
H
H
R 2
R 1
+
Ph
Ph
[MnBr(CO) 5 ] (10 mol%)
N
R 2
Ph
Ph
R 1
1
2
4
N
Ph
Ph
R
R
4a: R = OMe, 89 %
4b: R = F, 75 %
4c: R = H, 63 %
N
R
Ph
Ph
N
Ph
Ph
Me
Me
Me
R
4d: R = n Bu, 86 %
4e: R = i Pr, 82 %
4f: R = s Bu, 87 %
4g: R = OMe, 93 %
4h: R = NMe 2 , 97 %
+
H 2
1,4-dioxane (0.1 M)
105 °C, 12 h
Scheme 5.3 Manganese-catalyzed annulation of imines and alkynes
5 Fourth-Generation Oxidative Cross-Coupling Reactions