N
R
2
R
3
O
N
R
2
O
R
3
R
1
R
1
2 equiv TBHP
R
4
R
5
OH
HO R
4
R
5
N
O
N
O
N
O
HO
HO
HO
Cl
91%
OH
41%
NC
63%
+
100 °C
H
N
R 1 R 2
O
N
R
1
O
R
2
H
OH
H
TBHP
H
OH
OH
H
N
R
1
O
R 2
OH
H
TBHP
N
R
1
O
R
2
OH
H
I
II
III
Scheme 4.43 Reaction of activated alkenes and alcohols
+
N
O
R
1
R
2
O
O
10 mol% AgNO 3
1 equiv K 2 S 2 O 8
H 2 O, 50 °C
N
O
R 2
R 1
O
O
N
O
R
2
R 1
O
O
H
Scheme 4.44 Oxidative cyclization of acrylamides with 1,3-dicarbonyls
R
2
R
3
O
N
R
2
O
R
3
R
1
R
1
2 equiv TBHP
R
4
R
5
OH
HO R
4
R
5
N
O
N
O
N
O
HO
HO
HO
Cl
91%
OH
41%
NC
63%
+
100 °C
H
N
R 1 R 2
O
N
R
1
O
R
2
H
OH
H
TBHP
H
OH
OH
H
N
R
1
O
R 2
OH
H
TBHP
N
R
1
O
R
2
OH
H
I
II
III
Scheme 4.43 Reaction of activated alkenes and alcohols
+
N
O
R
1
R
2
O
O
10 mol% AgNO 3
1 equiv K 2 S 2 O 8
H 2 O, 50 °C
N
O
R 2
R 1
O
O
N
O
R
2
R 1
O
O
H
Scheme 4.44 Oxidative cyclization of acrylamides with 1,3-dicarbonyls