(38)
(39)
(40)
(41)
4.3 Miscellaneous Nucleophiles
The potential of P-based nucleophiles in the copper-promoted dehydrogenative
aromatic coupling was reported by the research group of Chen and Yu (Eq. 42)
[73]. With the assistance of the N,N-bidentate coordination of the aminoquinoline,
the copper-catalyzed C–P formation of aromatics with dialkylphosphonates proceeds to produce the corresponding aryl phosphonates in good yields.
(42)
Some halogen sources, such as LiCl, NCS, and NIS, also couple with aromatic
C–H bonds to form the corresponding C–halogen bonds under appropriate copper
catalysis [7, 74–78]. Some representative examples are illustrated in Eqs. (43) to
(45).
Copper-Mediated Intermolecular C–H/C–H and C–H/N–H Couplings via. . .
59