(14)
(15)
(16)
(17)
(18)
The same research group also developed the formal dehydrogenative construction of benzofuran- and indole–azole conjugations via an annulative metalation of
ortho-alkynylphenols and ortho-anilines (Scheme 1) [39, 40]. In the case of the
aniline, the substituent on the nitrogen is spontaneously removed after the C–C
formation to form the free NH indole exclusively. This protocol requires the alkyne
and heteroatom functions in one coupling partner but can provide a unique
approach to the biologically important bi(heteroaryl)s from nonhalogenated and
nonmetalated starting materials.
2.3 Alkylation
The copper-mediated dehydrogenative alkylation of aromatic compounds is less
investigated, compared to the alkynylation and arylation in Sects. 2.1 and 2.2. The
limited successful example includes the quinoline-containing benzamide and
Copper-Mediated Intermolecular C–H/C–H and C–H/N–H Couplings via. . .
53
(15)
(16)
(17)
(18)
The same research group also developed the formal dehydrogenative construction of benzofuran- and indole–azole conjugations via an annulative metalation of
ortho-alkynylphenols and ortho-anilines (Scheme 1) [39, 40]. In the case of the
aniline, the substituent on the nitrogen is spontaneously removed after the C–C
formation to form the free NH indole exclusively. This protocol requires the alkyne
and heteroatom functions in one coupling partner but can provide a unique
approach to the biologically important bi(heteroaryl)s from nonhalogenated and
nonmetalated starting materials.
2.3 Alkylation
The copper-mediated dehydrogenative alkylation of aromatic compounds is less
investigated, compared to the alkynylation and arylation in Sects. 2.1 and 2.2. The
limited successful example includes the quinoline-containing benzamide and
Copper-Mediated Intermolecular C–H/C–H and C–H/N–H Couplings via. . .
53