(Scheme 30a) [56] or basic conditions [57] (Scheme 30b). The 8-aminoquinoline
moiety was removed by treatment with HCl in refluxing methanol [58] or BF 3 •Et 2 O
in methanol at 100
C to give the corresponding ester [59]. The 8-aminoquinoline
moiety was converted into the corresponding aldehydes via a reaction with
Schwartz’s reagent (ZrHClCp 2 ) [60] (Scheme 30c). The 2-pyridinylisopropylamine moiety can also be easily removed by a mild sequence consisting
Scheme 28 Ni-catalyzed intramolecular amidation of C–H bonds
Scheme 29 A proposed reaction mechanism for the Ni-catalyzed amidation of C–H bonds
42
N. Chatani
moiety was removed by treatment with HCl in refluxing methanol [58] or BF 3 •Et 2 O
in methanol at 100
C to give the corresponding ester [59]. The 8-aminoquinoline
moiety was converted into the corresponding aldehydes via a reaction with
Schwartz’s reagent (ZrHClCp 2 ) [60] (Scheme 30c). The 2-pyridinylisopropylamine moiety can also be easily removed by a mild sequence consisting
Scheme 28 Ni-catalyzed intramolecular amidation of C–H bonds
Scheme 29 A proposed reaction mechanism for the Ni-catalyzed amidation of C–H bonds
42
N. Chatani